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1.
Amphotericin B (AMB) was often used in intra-articular injection administration for fungal arthritis, because it could often bring a satisfactory therapeutic efficacy and a minimum systemic toxic side effect. However, because of the multiple operations and the frequent injections, the compliance of the patients was bad. Therefore, to develop a long-term sustained-released preparation of AMB for mycotic arthritis intra-articular administration is of great significance. The purpose of present study was to develop a long-term sustained-released in situ gel of a water-insoluble drug AMB for mycotic arthritis intra-articular administration. Based on the evaluations of the in vitro properties of the formulations, the formulation containing 10% (w/w) ethanol, 15% (w/w) PG, 0.75% (w/w) HA, 5% (w/w) purified soybean oil, 0.03% (w/w) α-tocopherol, 15% (w/w) water and 55% (w/w) glyceryl monooleate was selected as a suitable intra-articular injectable in situ gel drug delivery system for water-insoluble drug AMB. Furthermore, the results of the in vivo study on rabbits showed that the selected formulation was a safe and effective long-term sustained-released intra-articular injectable AMB preparation. Therefore, the presented in situ AMB gel could reduce the frequency of the administration in the AMB treatment of fungal arthritis, and then would get a good patient compliance. 相似文献
2.
The present paper concerns the induction of stable sustained oscillation in feedback-linearizable single-input affine nonlinear dynamical systems via continuous-time state feedback control. The proposed application-oriented control approach is based on the conception of a state feedback controller that ensures the tracking of a limit cycle characterized in terms of the feedback-linearized system. Boundedness and convergence of the closed-loop trajectories are established following the Lyapunov theoretical framework and applying LaSalle׳s stability principle. The proposed approach is demonstrated with computer-simulated control experiments, showing that it ensures the convergence of the state trajectories of the controlled system to a designed limit cycle and that the methodology can, in principle, be applied to any single input feedback linearizable system. 相似文献
3.
简述了我国钨矿业概况、现有采选技术水平及钨矿加工利用率 ;从资源配置出发 ,阐述了钨矿业发展存在的几个主要问题 ,并且针对性地提出了可持续发展的几点建议。 相似文献
4.
An investigation of pore cracking in titanium welds 总被引:1,自引:0,他引:1
T. Khaled 《Journal of Materials Engineering and Performance》1994,3(1):21-36
Two welded Ti-6A1-4V pressure vessels leaked prematurely in service. The leaks were caused by cracks emanating from weld porosity.
The cracks originated during fabrication, with subsequent growth in service leading to the formation of the leak paths. Pore
cracking is thought to be caused by a mechanism that involves both sustained-load and cyclic contributions, with the former
being the more prominent. It is shown that the tendency for cracking is influenced by pore position and that pore size is
not a deciding factor in that regard. The factors that govern pore cracking are discussed, and the possible role of interstitial
embrittlement is assessed. 相似文献
5.
随着工农业发展和人口的增长,南流江流域水资源供需矛盾日益突出,水资源的可持续利用日益显得重要,针对流域水资源特点,提出加强水资源统一管理,实施跨流域调水,加强水资源保护等对策。 相似文献
6.
《Canadian Metallurgical Quarterly》2003,39(3):581
The role of attention processes as possible mediators between family environment and school readiness was analyzed with data from 1,002 children and their families. Data on children's sustained attention, impulsivity, and school readiness (i.e., cognitive, achievement, language, and social development) were obtained at 54 months of age, and quality of the family environment was assessed throughout the first 54 months. Mediation tests showed that children's sustained attention partially accounted for the link between family environment and achievement and language outcomes. Impulsivity partially accounted for the link between family environment and achievement, social competence, and externalizing behaviors. The roles of sustained attention and of inhibition of impulsive responding in the relation between family characteristics and school readiness are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
7.
为改善皮革的特殊气味并提升其应用性能,该研究以玉米醇溶蛋白(Zein)、艾叶香精(AAE)以及普兰尼克F127等为原料,通过反溶剂法制备缓香型玉米醇溶蛋白微胶囊(AAE@ZMs)乳液,再将AAE@ZMs乳液与成膜剂己内酰胺改性酪素复配后应用于皮革涂饰。结果表明,Zein与F127、AAE和戊二醛通过化学交联和氢键相互作用,同时F127和AAE可使Zein中的氨基酸重排并发生荧光猝灭;制得的AAE@ZMs乳液中微胶囊平均粒径约为298.6 nm且具有较好的分散性和稳定性;AAE@ZMs的包覆率和负载率分别可以达到73.2%和5.8%,在良溶剂中释放120 h时的AAE累积释放率约为83.1%。将AAE@ZMs应用于皮革涂饰后,涂饰革样中AAE的释放周期为6周,对金黄色葡萄球菌和大肠杆菌均具有较好的抑制效果,同时涂饰革样还展现出较好的机械性能。 相似文献
8.
氢能——我国未来的清洁能源 总被引:1,自引:0,他引:1
首先介绍了氢能的诸多优点,例如资源丰富、来源多样性、可再生性和可储存性等,特别指出氢的可储存性使其具有和电、热不同的能源载体的用途。进而就我国能源资源情况、能源安全、环境要求以及经济可持续发展的角度说明我国发展氢能的必要性。说明发展氢能燃料电池汽车、分散供电、供热都将是我国经济持续发展的新的增长点。当前,各国制定氢能发展规划,加大发展氢能的力度,出现氢能国际化的苗头。对此,作者建议应根据我国国情特点,制定我国的氢能发展计划和目标,同时,积极参与氢能国际化活动,为我国的可持续发展争取条件。 相似文献
9.
10.