面向AIS医疗应用服务的系统研究与开发

肿瘤是当前医学领域尚未完全攻克的难题,针对这一现象,提出了一种借用人工免疫系统模型,通过嵌入式技术等实现手段,探讨了利用人工智能技术治疗肿瘤病患者的方法。该思路的重点在于利用人工免疫网络具备联想、耐受与自稳等特性,通过将其以适当的方式作用于人体,达到激发人体固有免疫系统,恢复原有免疫功能、提升人体抵抗病原侵入的能力,从而达到自愈的目的。详细介绍了系统的设计方法、硬件构成和应用情况,在一定程度上为人工免疫网络的应用研究拓宽了思路。     

Autoimmune Neutropenia and Immune-Dysregulation in a Patient Carrying a TINF2 Variant

In recent years, the knowledge about the immune-mediated impairment of bone marrow precursors in immune-dysregulation and autoimmune disorders has increased. In addition, immune-dysregulation, secondary to marrow failure, has been reported as being, in some cases, the most evident and early sign of the disease and making the diagnosis of both groups of disorders challenging. Dyskeratosis congenita is a disorder characterized by premature telomere erosion, typically showing marrow failure, nail dystrophy and leukoplakia, although incomplete genetic penetrance and phenotypes with immune-dysregulation features have been described. We report on a previously healthy 17-year-old girl, with a cousin successfully treated for acute lymphoblastic leukemia, who presented with leukopenia and neutropenia. The diagnostic work-up showed positive anti-neutrophil antibodies, leading to the diagnosis of autoimmune neutropenia, a slightly low NK count and high TCR-αβ+-double-negative T-cells. A next-generation sequencing (NGS) analysis showed the 734C>A variant on exon 6 of the TINF2 gene, leading to the p.Ser245Tyr. The telomere length was short on the lymphocytes and granulocytes, suggesting the diagnosis of an atypical telomeropathy showing with immune-dysregulation. This case underlines the importance of an accurate diagnostic work-up of patients with immune-dysregulation, who should undergo NGS or whole exome sequencing to identify specific disorders that deserve targeted follow-up and treatment.     

基于AIN信息融合方法的应用研究

信息融合技术是一种集成多个传感器数据以获得更加精确的检测和识别结果的技术。如何有效地集成多源检测数据以充分发挥各种检测数据的作用,从而获得最好的检测和识别结果,仍然是信息融合技术应用的关键问题,引起了人们广泛的关注和探索。提出采用人工免疫网络（Artificial Immune Network,AIN）作为模式识别领域中信息融合技术的融合算法,并做出了初步的尝试,两个实验证明了AIN作为信息融合算法的可行性和有效性。     

单晶AlN纳米线的合成和光致发光特性研究

在无催化剂和模板条件。利用直流电孤放电等离子方法直接氮化金属铝合成纤锌矿结构的单晶AIN纳米线．分别用X光射线衍射（XRD）和场发射扫描电镜（FESEM）对AIN纳米线的结构和形貌进行表征,并测量了AIN纳米线的光致发光谱（PL）．结果表明,A1N纳米线的长度超过100μm,直径大约200nm,具有较高的长径比;在AIN纳米线的PL谱中,中心在506nm的发射带源于氮空位相关的深能级缺陷．     

A parallelized artificial immune network for fuzzy clustering

An artificial immune network (AIN), AINFCM, has been successfully used for fuzzy clustering to overcome the shortage of FCM algorithm that is sensitive to the selection of initial centres. However, as a stochastic searching algorithm, the runtime of AINFCM goes up especially when dealing with large quantities of data or generating much more antibodies for clone selection. In this paper, the PAINFCM is proposed for parallel affinity calculation of antibodies according to time complexity of AINFCM algorithm. Subsequently, a coarse-grained version of PAINFCM algorithm was proposed to parallelize clone expansion. Experiments indicated that the PAINFCM improves efficiency of AIN. Furthermore, it provides a good balance between global searching ability and run time of the AIN.     

GaN／AIN量子点结构中的应变分布和压电效应

从Ⅲ-Ⅴ族氮化物半导体压电极化对应变的依赖关系出发，采用有限元方法计算了GaN／AIN量子点结构中的应变分布，研究了其自发极化、压电极化以及极化电荷密度．结果表明，应变导致的压电极化和Ⅲ-Ⅴ族氮化物半导体所特有的自发极化将导致电荷分布的变化，使电子聚集在量子点顶部，空穴聚集在量子点下面的湿润层中，在量子点结构中产生显著的极化电场，并讨论了电场的存在对能带带边的形状以及能级分布的影响．     

氮化铝超微细粉制备规律的研究

利用直流电弧等离子体具有的高温、高反应活性和高的急冷速度等特点，通过氮等离子体与金属铝反应的方法，制备了平均粒径为５０ｕｍ的高纯氮化铝（ＡＩＮ）超微细粉，并对氮化反应原理及ＡｌＮ的成核机理进行了探讨。结果表明，等离子条件下的化学反应是极其复杂的，等离子态有利于氮化反应。ＡｌＮ的成核速率与反应物的浓度和反应温度有关。实验中，通过控制反应气体的分压、反应的温度及冷却速度等工艺参数，制备出了粗径可控的ＡｌＮ超微细粉。     

EFFECT OF HEAT-TREATMENT ON THE MECHANICAL PROPERTIES OF AIN/SICw(Y_2O_3+SiO_2)COMPOSITE

In the paper, the effect of heat-treatment on thestrength and toughness of AlN-SiC whisker composites with Y_2O_3+SiO_2 additives have been studied. When the sample contining 10wt%Y_2O_3+SiO_2(Y_2O_3/SiO_2=1/0. 66) was treated at 1330℃ in air for 140hours,the flexural strength of composites was raised from 481 MPa to784 MPa the toughness was also enhanced slightly. The phase composi-tion microstructure and grain boundary phase structure have been char-acterized by combining XDR, SEM, TEM/EDXA and HREM tech-niques. reinforcenent and toughening mechanism of the composites re-sults from the crystallization of glass phase in the grain boundary atthe high temperature oxidizing atmosphere to form the crossing struc-ture of 2H°sialon fibrous phase and SiC whisker     

用于高温压力传感器的AIN绝缘膜的研究

采用直流磁控反应溅射法制备了高温压力传感器用的AIN薄膜。用X射线衍射对薄膜的晶向结构进行了分析，研究了薄膜的绝缘特性和化学稳定性，分析了AIN与Si的热膨胀系数、热导系数的关系。选用AIN在力敏电阻条和硅弹性膜之间进行绝缘隔离，由于无p-n结，力敏电阻无反向漏电，得到了极好的压力传感器特性，即零点电漂移及热漂移小及非线性小。     

反应溅射AlN的模拟

研究了用反应磁控溅射的方法制备氮化铝薄膜。由于铝和氮化铝二次电子发射系数有很大的不同,导致制备时会在金属模式和化合物模式间出现一个很大的跃迁。为了准确描绘实验结果,建立了一个反应溅射模型。该模型以Berg在1988年提出的模型为基础,包括了靶上二次电子发射系数的变化。利用该模型能够预测溅射行为,计算结果与实测值相符。