Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder.

There is a growing body of data indicating that Gene × Child Maltreatment interactions at monoamine oxidase A (MAOA) play a role in vulnerability to symptoms of antisocial personality disorder (ASPD) but not major depression (MD). Using a sample of 538 participants from the Iowa Adoption Studies, we introduce a conceptual model that highlights two distinct pathways from child maltreatment to symptoms of MD, suggesting that maltreatment has different effects depending on genotype and highlighting the importance of including the indirect pathway through ASPD. As predicted by the model, high activity alleles predispose to symptoms of MD in the context of child maltreatment whereas low activity alleles predispose to symptoms of ASPD. We conclude that the Gene × Environment interplay at this locus (MAOA) contributes to both symptoms of ASPD and MD and that careful specification of child maltreatment may be essential if genetic association research is to produce replicable results. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

激发极化法在西藏昂青银多金属矿勘查中的应用

西藏昂青银多金属矿床为大型矽卡岩型银、铅、锌、铜多金属硫化物矿床,矿体赋存于中—下三叠统马拉松多组第一岩性段矽卡岩、大理岩地层中,矿化有黄铁矿化、方铅矿化、闪锌矿化和黄铜矿化等。运用激电中梯扫面方法,在矿区圈出JD1和JD2两个低阻高极化激电异常,JD1异常长1500 m,宽700 m,视极化率η_s:6.03%～14.2%,视电阻率ρ_s:22. 1～197 n·m,;JD2异常长900 m,宽500 m,视极化率η_s:6.04%～9.70%,视电阻率ρ_s:100～494Ω·m。两异常经钻孔验证,均见到隐伏银—铅—锌—铜多金属矿体,累计见矿30条。运用激电测深推测矿化体顶板埋深,钻孔验证基本相符。研究结果表明,激发极化法在昂青银多金属矿床勘查中有良好的应用效果。