Characterizations of friction welding joint interface for AISI 316

Because of heat amount is different from peripheral to central of friction welding interface, which is leaded to vary the characterizations along that interface. Current study, respectively, focused on the effect of different friction pressure on micro-structural and mechanical properties of that friction welding joint interface. Presently, these friction pressures are 110, 130, 150 and 170 MPa while kept all other conditions constant. The effects of different friction pressure on welding interface characterization were investigated by EDX, SEM, tensile, compression, impact and hardness tests. The tensile tests carried out on the standardized test piece with diameter 6 mm and 8 mm, thus, compression tests were extracted from the positions of 0°, 45° 90° with test specimen of 4 mm diameter and 6.5 mm length at weld center. Whereas, the impact test pieces were picked up in two positions, the first one is symmetrical, which it obtained to the respect of the rotation axis and the interface, on the other hand, the second one is non-symmetrical with the axis of rotation and symmetrical to the interface, for making the notch head coincide with the center of the welded joint, The obtained results showed that with reducing of friction pressure will present lack of bonding increasing from peripheral toward the welding center, which will responsible on reducing of the mechanical properties such as tensile, compression and impact strength.     

青年医学工作者科普能力培养新模式

为了培养青年医师运用医学科普语言传播医学知识的能力，向社会提供更优质、可及的健康知识，改善医患关系，促进社会和谐；同时出于向社区、媒体推送一批优秀青年医学科普人才的考虑，本文在总结北京协和医院培养青年医务人员医学科普能力经验的基础上，尝试构建一套适合大型公立医院（尤其是教学医院）培养青年医务人员医学科普能力的新模式——“科普训练营”。本文旨在系统介绍该模式的产生背景、实践经验及初期效果，阐释实施后的重要意义，及实施过程中的挑战与应对策略。     

气管上段腺样囊性癌的临床病理

目的　探讨气管上段腺样囊性癌的临床病理特征及诊断和鉴别诊断要点。方法　收集2000年1月至2014年2月在北京协和医院确诊的4例气管上段腺样囊性癌病例，通过光镜、免疫组织化学及组织化学染色分析其临床病理特征、免疫组织化学特点、诊断及鉴别诊断要点。结果　4例气管上段腺样囊性癌患者中，男1例，女3例，平均年龄47岁(38~57岁）；既往均无腺样囊性癌病史，1例患者既往有结节性甲状腺肿手术史。镜下检查4例均为筛状/管状型腺样囊性癌，3例累及甲状腺组织，3例累及神经组织，未见淋巴结受累。免疫组织化学染色示4例P16、CD117、BCL2、P63、SMA均阳性，Ki67指数平均8%，TTF1和P53均阴性；4例中基底膜样物胶原Ⅳ阳性；组织化学染色示AB/PAS阳性。术后均接受总剂量为48~56 Gy的放疗，随访6~120个月，平均72.5个月，1例术后96个月复发，3例随访期间无复发及转移。结论　气管上段腺样囊性癌是罕见的原发于气管的低度恶性肿瘤，肿瘤生长缓慢，就诊时多数已侵及甲状腺组织，需要与原发于甲状腺的恶性肿瘤相鉴别，特别是在甲状腺穿刺及术中冰冻检查时。结合电子喉气管镜下表现、典型的形态学及免疫组织化学和组织化学染色有助于准确诊断。手术难以切除干净，术后放疗对延缓疾病复发有一定帮助。     

Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances

Carriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and (c) burst drug release which can be pharmacologically dangerous and economically inefficient. The present study brings a novel strategy for encapsulation and controlled release of PWSAS—caffeine in concentrations which are higher than its maximal water solubility without the possibility of burst effect. The modification of hydrophilic carrier based on poly(methacylic acid) was done using casein and liposomes. To further increase the maximal caffeine loading inside the carrier nicotinamide was used. The release study of the encapsulated PWSAS was elaborated with respect to morphology of the carriers and interactions that could be established between its structural components. The carriers swelling and the release of caffeine and nicotinamide were also investigated depending on caffeine concentration, the presence of different liposomal formulations and the volume ratio of liposomal formulation, in three media with different pH simulating the path of the carrier through the human gastrointestinal tract. The synthesized carriers are promising candidates for encapsulation of PWSAS in concentrations which are higher than its maximal water solubility and for the targeted delivery of those dosages.     

存在飞轮安装偏差与故障的卫星姿态容错控制

基于滑模控制理论提出一种刚体卫星姿态稳定控制方法,实现对反作用飞轮部分失效故障的容错控制,以及对其安装偏差的补偿控制,并从理论上证明了所设计的控制器在有限时间内能够实现对闭环姿态控制系统的几乎全局渐近稳定控制.最后将所设计的控制器应用于某型卫星姿态稳定任务,仿真结果验证了所提出方法的有效性.     

基于损益云模型的制造车间重调度决策方法

针对制造车间重调度触发机制问题,建立了制造车间重调度损益函数,揭示了生产车间重调度过程损失及增益的变化规律.引入云理论测度重调度损益的不确定性,使用逆向云算法计算重调度增益云和损失云的数字特征,根据云形态预测重调度损益变化趋势.提出一种基于损益云模型的重调度决策方法以判断是否需要重调度,并利用最佳损益比甄选预调度方案以兼顾生产系统的稳定性和有效性.最后,通过实例验证了该方法的合理性和实用性.     

具有时延和丢包的NCS鲁棒H∞控制

针对一类含有不确定参数的网络控制系统(NCS),研究网络中存在时延与丢包情况下的鲁棒?∞控制问题.构造一个新的Lyapunov-Krasovskii泛函,并基于改进的Wirtinger不等式推导出闭环NCS渐近稳定且满足?∞性能的充分条件,该条件能得到比已有文献保守性更小的结果.给出线性锥补算法以实现次优鲁棒?∞控制器增益的求解.最后通过多个数值实例验证了所提出方法的有效性.     

混合估计多模粒子滤波的机动弱小目标检测前跟踪算法

针对低信噪比条件下的机动小目标实时检测与跟踪困难的问题, 提出一种基于混合估计多模粒子滤波的检测前跟踪改进算法. 首先根据前一时刻所采用的模型状态及其转移概率等先验信息实现当前时刻的模型采样; 然后在充分考虑当前量测下实现当前的粒子预测, 采用一种序贯重要性平滑重采样策略, 在不增加计算量的前提下, 改善了粒子多样性衰退的问题; 最后通过新的粒子集完成对模型和状态的合理估计与目标检测. 仿真结果验证了该方法的检测与跟踪性能优于传统的多模粒子滤波方法.

     

晃动基座下捷联惯导的抗干扰自对准算法

针对捷联惯导(SINS) 晃动基座下, SINS 难以快速实现自对准的问题, 提出SINS 的抗干扰自对准算法. 该算法通过将初始对准问题转化为Wahba 求解问题来消除角运动干扰的影响; 利用惯性坐标系重力矢量和晃动干扰加速度的频率特点, 通过设计低通滤波器对比力在惯性坐标下的投影进行滤波来消除线振动干扰的影响. 仿真结果表明, 该算法不需要进行粗对准, 能够在角运动干扰和线振动干扰同时存在的情况下快速实现自对准.

     

四相永磁容错电机短路故障容错策略

四相永磁容错电机采用被容错齿隔开的集中式绕组结构,本质上具有一定的容错能力和故障出现后连续运行的能力.针对H桥和星形这两种驱动拓扑结构,在发生单相绕组出线端部短路时,以容错控制后的转矩满足正常需求为目标,分别采用直接转矩补偿方法和旋转磁动势不变方法进行容错控制;对两种容错控制策略进行了推导和对比分析,并对相关结果进行了磁-路联合仿真计算,验证了理论分析的正确性.