药物相互作用研究在新药研发和审评决策中的应用

药物相互作用改变了剂量效应关系，可能会降低疗效或增加毒性，是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义，体内和体外研究的主要内容；梳理分析了2020年国家药品监督管理局（National Medical Products Administration, NMPA）和美国食品药品监督管理局（Food and Drug Administration, FDA）批准上市的新药药物相互作用研究情况，旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。     

An Analysis of Citation Counts of ETRI‐Invented US Patents

From its foundation until 2004, ETRI has registered over 1,000 US patents. This letter analyzes the characteristics of these patents and addresses the explanatory factors affecting their citation counts. For explanatory variables, research team related variables, invention specific variables, and geographical domain related variables are suggested. Zero‐altered count data models are used to test the impact of independent variables. A key finding is that technological cumulativeness, the scale of invention, outputs in the electronic field, and the degree of dependence on the US technology domain positively affect the citation counts of ETRI‐invented US patents. The magnitude of international presence appears to negatively affect the citation counts of ETRI‐invented US patents.     

Interstate forensic psychology consultations: A call for reform and proposal of a model rule.

Forensic psychology has made important gains in professional recognition and stature in the courts, resulting in increasing demands for mobility of expertise. Current regulations regarding the interjurisdictional temporary forensic practice of psychology, however, are characterized by variability of regulations, ambiguity and inaccessibility, and continuing total barriers. A uniform, well-reasoned policy is needed. A conceptual basis for such a policy is provided by a discussion of licensing rationales and the application of these to forensic practice. Uniformity, public and professional protection, and practicability are identified as fundamental regulatory criteria. A Model Rule Regarding the Temporary Forensic Practice of Psychology is proposed for adoption by state licensing boards on a nationwide basis. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

美国MK48系列鱼雷发展历程带给我们的启示

美国MK48系列鱼雷以其航程远、威力大而著称。经过40多年来的研制、改进和发展，目前已成为了世界上最杰出、最典型的大型鱼雷之一。该文仅根据其发展历程，从注重现役鱼雷的改造利用、抗干扰性能、浅水性能、良性竞争、新技术的开发以及标准化建设6个方面提出了带给我们的一些启示，供鱼雷研制和武器采购部门参考。     

人民币汇率机制改革中参考一篮子货币的思考

分析了人民币汇率机制改革中选择“参考一篮子货币”制的原因;在肯定这次汇率制度改革给我国带来的有利影响,同时指出了参考一篮子货币制在短期内将面临的问题,并进一步提出关于完善该汇率制度的相关措施和建议,以期对我国汇率制度改革提供参考。     

美军装备试验鉴定技术发展需求生成问题研究

纵观世界装备试验鉴定技术发展,美军拥有庞大的试验鉴定靶场、雄厚的试验鉴定技术基础、先进的试验鉴定理论、相对完善的组织管理体制,其装备的试验鉴定水平和能力处于世界领先地位.研究美军试验鉴定技术发展现状,预测其在未来一个时期内的发展趋势,总结其发展特点与规律,学习借鉴先进经验做法,对于我国装备建设发展、试验鉴定能力提升和靶场建设有着重要的现实意义.主要对美军试验鉴定技术发展历程、管理体制与规划计划进行介绍,凝练其在试验鉴定技术发展需求中生成的总体思路和主要做法,在此基础上提出思考建议,以期对我国装备试验鉴定技术发展提供一定启示与借鉴.     

A coarse-to-fine IP-driven registration for pose estimation from single ultrasound image

A fast registration making use of implicit polynomial (IP) models is helpful for the real-time pose estimation from single clinical free-hand Ultrasound (US) image, because it is superior in the areas such as robustness against image noise, fast registration without enquiring correspondences, and fast IP coefficient transformation. However it might lead to the lack of accuracy or failure registration.In this paper, we present a novel registration method based on a coarse-to-fine IP representation. The approach starts from a high-speed and reliable registration with a coarse (of low degree) IP model and stops when the desired accuracy is achieved by a fine (of high degree) IP model. Over the previous IP-to-point based methods our contributions are: (i) keeping the efficiency without requiring pair-wised correspondences, (ii) enhancing the robustness, and (iii) improving the accuracy. The experimental result demonstrates the good performance of our registration method and its capabilities of overcoming the limitations of unconstrained freehand ultrasound data, resulting in fast, robust and accurate registration.     

The use of mindmapping software for patent search and management

Modern information technologies and in particular the internet have revolutionized the patent information professionals' work in terms of speed of access and information comprehensiveness from both company internal and external digital sources. Here, I describe how the digital mindmapping technique can be used to complement existing intellectual property management software solutions to meet the challenge of optimizing and managing patent search workflows as well as to rapidly organise and access highly dynamic, heterogeneous and scattered patent information sources. Both eye catching and highly memorable and at the same time self-explanatory mindmapping examples are presented. These were designed to include basic and advanced level digital mindmapping features tailored to significantly speed up and maintain a high work quality level of patent search professionals. A special emphasis is put on the great benefit of organising and accessing the plethora of internet-based worldwide online patent registers through mindmapping, both in terms of managing the constantly changing deep links to the actual search options for e.g., legal status information, and keeping track of the offered level of content.     

Automated breast cancer detection and classification using ultrasound images: A survey

Breast cancer is the second leading cause of death for women all over the world. Since the cause of the disease remains unknown, early detection and diagnosis is the key for breast cancer control, and it can increase the success of treatment, save lives and reduce cost. Ultrasound imaging is one of the most frequently used diagnosis tools to detect and classify abnormalities of the breast. In order to eliminate the operator dependency and improve the diagnostic accuracy, computer-aided diagnosis (CAD) system is a valuable and beneficial means for breast cancer detection and classification. Generally, a CAD system consists of four stages: preprocessing, segmentation, feature extraction and selection, and classification. In this paper, the approaches used in these stages are summarized and their advantages and disadvantages are discussed. The performance evaluation of CAD system is investigated as well.