快速灵敏的LC-MS/MS法测定人血浆中阿莫西林并应用于两种制剂的一致性评价

目的: 建立快速灵敏的LC-MS/MS法测定人血浆中阿莫西林浓度，并用于两种阿莫西林胶囊的一致性评价。方法: 采用岛津公司LCMS-8060型LC-MS/MS仪，以MRM模式测定阿莫西林（m/z 366.00/114.00）的浓度，d4-阿莫西林作内标（m/z 370.10/114.05），离子源为ESI源。色谱柱选用Waters ACQUITY BEH C18（2.1×50 mm，1.7 μm），梯度洗脱。血浆样本加入内标，经甲醇沉淀蛋白后取上清液进样检测。结果: 所建方法经验证，其线性、准确度、精密度、最低定量限、提取回收率、特异性、基质效应、稳定性等各项指标均符合CFDA的指导原则及最新核查标准要求，并较文献报道中的方法有处理简单、灵敏度高、色谱峰形好的优点。结论: 所建方法快速、灵敏，适用于人血浆中阿莫西林浓度的检测。用于一致性评价的样本实测，两种制剂生物等效。     

Systematic convergence of nonlinear stochastic estimators on the Special Orthogonal Group SO(3)

This paper introduces two novel nonlinear stochastic attitude estimators developed on the Special Orthogonal Group with the tracking error of the normalized Euclidean distance meeting predefined transient and steady‐state characteristics. The tracking error is confined to initially start within a predetermined large set such that the transient performance is guaranteed to obey dynamically reducing boundaries and decrease smoothly and asymptotically to the origin in probability from almost any initial condition. The proposed estimators produce accurate attitude estimates with remarkable convergence properties using measurements obtained from low‐cost inertial measurement units. The estimators proposed in continuous form are complemented by their discrete versions for the implementation purposes. The simulation results illustrate the effectiveness and robustness of the proposed estimators against uncertain measurements and large initialization error, whether in continuous or discrete form.     

药用辅料对CYP3A活性的影响及其对仿制药质量和疗效一致性评价的指导作用

药物制剂的处方和工艺是保证药物质量和疗效的基础，药用辅料是药物制剂处方的重要组成部分。部分药用辅料可影响CYP3A的活性，继而可能影响其底物在体内的代谢和生物利用度。在中国和美国，相对生物利用度是仿制药研究的关键内容。我国正在推进仿制药质量和疗效一致性评价。因此，了解药用辅料对CYP3A的影响及其对一致性评价的指导作用具有十分重要的现实意义。     

Parallel path consistency

Filtering algorithms are well accepted as a means of speeding up the solution of the consistent labeling problem (CLP). Despite the fact that path consistency does a better job of filtering than arc consistency, AC is still the preferred technique because it has a much lower time complexity. We are implementing parallel path consistency algorithms on multiprocessors and comparing their performance to the best sequential and parallel arc consistency algorithms.^(1,2) (See also work by Kerethoet al. ⁽³⁾ and Kasif⁽⁴⁾) Preliminary work has shown linear performance increases for parallelized path consistency and also shown that in many cases performance is significantly better than the theoretical worst case. These two results lead us to believe that parallel path consistency may be a superior filtering technique. Finally, we have implemented path consistency as an outer product computation and have obtained good results (e.g., linear speedup on a 64K-node Connection Machine 2).     

调整水量法(代用法)测定水泥标准稠度用水量方法的改进

结合兰州市的水泥标准稠度用水量方法测定 (代用法 )的实例 ,分析代用法测定标准稠度用水量的缺点 ,并对此方法提出了一些改进措施     

Measuring consistency in TTL-based caches

We propose a general modeling framework to evaluate the performance of cache consistency algorithms. In addition to the usual hit rate, we introduce the hit^* rate as a consistency measure, which captures the fraction of non-stale downloads from the cache. We apply these ideas to the analysis of the fixed TTL consistency algorithm in the presence of network delays. The hit and hit^* rates are evaluated when requests and updates are modeled by renewal processes. Classical results on the renewal function lead to various bounds.     

Application of Support Vector Machines in Assessing Conceptual Cost Estimates

Total conceptual cost estimates and the assessment of the quality of these estimates are critical in the early stages of a building construction project. In this study, the support vector machine (SVM) model for assessing the quality of conceptual cost estimates is proposed, and the application of SVM in construction areas is investigated. The results show that the SVM model assessed the quality of conceptual cost estimates slightly more accurately than the discriminant analysis model. This shows that using the SVM has potential in construction areas. In addition, the SVM model can assist clients in their evaluation of the quality of the estimated cost and the probability of exceeding the target cost, and in their decision on whether or not it is necessary to seek a more accurate estimate in the early stages of a project.     

Subdivision of work on construction projects

In order to control a project, construction management requires project information. This is obtained through accounting, estimating, cost management and scheduling functions which produce project reports. These reports are best obtained by subdividing the project into small parts. The ways in which each of these functions subdivides a project in order to produce its reports is discussed, together with a means of interrelating this information with a technique known as the work breakdown structure.     

多处理器系统中的数据局部性及其优化技术研究

数据局部性是多处理器系统中的重要研究方向之一。结合该领域目前国内外研究现状和我们近一阶段的研究进展，讨论了多处理器系统中的数据局部性及其优化问题。针对现有局部性度量模型存在的不足，提出了一种增强的可用于层次式并行计算机体系结构的局部性度量模型。在静态和动态局部性优化技术方面，分别探讨了基于投影分层的数据变换框架和基于瞬时访问信息的动态页迁移策略，并展开了系列相关的讨论。另外，针对利用数据局部性时必须解决的一个关键问题--存储一致性问题，进行了深入的研究，提出了以操作系统为中心的线程存储一致性模型。     

Accelerating filtering techniques for numeric CSPs

Search algorithms for solving Numeric CSPs (Constraint Satisfaction Problems) make an extensive use of filtering techniques. In this paper¹ we show how those filtering techniques can be accelerated by discovering and exploiting some regularities during the filtering process. Two kinds of regularities are discussed, cyclic phenomena in the propagation queue and numeric regularities of the domains of the variables. We also present in this paper an attempt to unify numeric CSPs solving methods from two distinct communities, that of CSP in artificial intelligence, and that of interval analysis.