Spinal Excitatory Dynorphinergic Interneurons Contribute to Burn Injury-Induced Nociception Mediated by Phosphorylated Histone 3 at Serine 10 in Rodents

The phosphorylation of serine 10 in histone 3 (p-S10H3) has recently been demonstrated to participate in spinal nociceptive processing. However, superficial dorsal horn (SDH) neurons involved in p-S10H3-mediated nociception have not been fully characterized. In the present work, we combined immunohistochemistry, in situ hybridization with the retrograde labeling of projection neurons to reveal the subset of dorsal horn neurons presenting an elevated level of p-S10H3 in response to noxious heat (60 °C), causing burn injury. Projection neurons only represented a small percentage (5%) of p-S10H3-positive cells, while the greater part of them belonged to excitatory SDH interneurons. The combined immunolabeling of p-S10H3 with markers of already established interneuronal classes of the SDH revealed that the largest subset of neurons with burn injury-induced p-S10H3 expression was dynorphin immunopositive in mice. Furthermore, the majority of p-S10H3-expressing dynorphinergic neurons proved to be excitatory, as they lacked Pax-2 and showed Lmx1b-immunopositivity. Thus, we showed that neurochemically heterogeneous SDH neurons exhibit the upregulation of p-S10H3 shortly after noxious heat-induced burn injury and consequential tissue damage, and that a dedicated subset of excitatory dynorphinergic neurons is likely a key player in the development of central sensitization via the p-S10H3 mediated pathway.     

The relative effects of transection of the gustatory branches of the seventh and ninth cranial nerves on NaCl taste detection in rats.

Chorda tympani nerve (CT) transection in rats severely impairs NaCl taste detection. These rats can detect higher concentrations of NaCl, however, suggesting that remaining oral nerves maintain some salt sensibility. Rats were tested in a gustometer with a 2-response operant taste-detection task before and after sham surgery (n = 5), combined transection of the CT and the greater superficial petrosal nerves (GSP; 7x, n = 6), or transection of the glossopharyngeal nerve (GL; 9x, n = 4). Thresholds did not significantly change after sham surgery. Although the GL responds to NaCl and innervates nearly 60% of total taste buds, 9x surgery had no effect. However, 7x surgery increased NaCl detection threshold by ～2.5 log?? units, greater than that reported for CT transection alone. These results suggest that the GSP contributes to NaCl sensitivity in rats and also demonstrate that the GL and perhaps the superior laryngeal and lingual nerve proper can maintain some NaCl detectability at high concentrations. These findings confirm the primacy of the 7th nerve relative to the 9th nerve in sensibility of NaCl in the rat model. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

变性淀粉取代聚乙烯醇生产Al2O3刚玉陶瓷的胶粘剂研究

论述了变性淀粉取代聚乙烯醇(PVA)生产Al2O3刚玉陶瓷的意义及聚乙烯醇结构与吸附性能的关系，并且根据胶粘机理，通过分析Al203胶粒的表面特性和变性淀粉的结构，说明了变性淀粉可以取代聚乙烯醇。     

Scanning electron microscopy of nerve fibers in human fetal cochlea

The cochleas of four human fetuses ranging 22–25 weeks gestation were studied by scanning electron microscopy (SEM) for the purpose of obtaining a better understanding of the nerve fiber arrangement in the human ear. After critical point drying, the specimens were dissected and the floor of the tunnel of Corti and the outer wall of Nuel's space were exposed for observation. Upper cochlear turns, especially the apical turn, seemed to be still immature. Observed nerve fibers were classified into three types:

• 1 Spiral fibers: Fibers traveling basalward and following the shape of the cochlea were found in both the tunnel of Corti and Nuel's space and believed to be the afferent nerves responsible for innervating the outer hair cells
• 2 Radial fibers: radiating outward from the osseous spiral lamina—one such radial fiber transversing high in the tunnel space (supposedly the efferent nerve servicing the outer hair cells), and another sort of radial fiber (found crossing the tunnel floor), the nature of which was uncertain.
• 3 Irregular fibers: Consisting of thin, randomly running fibers within the cochlea. The destination of these fibers was not determined, but possibly they represent transitory nerve branchings of afferent or more probably efferent nerves, which would later regress during maturation.

     

Enhanced luminescence and thermal stability of (Sr,Ca)AlSiN3:Eu2+ via superficial organic carbon modification

The Eu²⁺-activated nitride phosphors have been widely used in solid-state lighting, but the applications in high-power white-light-emitting diodes (wLEDs) field require higher thermal stability of luminescent materials. The oxidation of Eu²⁺ and the damage of nitride host in the Eu²⁺-activated nitride phosphors are the two crucial reasons for the luminescence loss while operating. A superficial organic carbon modification is performed on the red-emitting (Sr,Ca)AlSiN₃:Eu²⁺ phosphor via the incorporation of organic carbon by solution mixing and thermal post-treatment under the N₂-H₂ atmosphere. After the superficial organic carbon modification, the oxidation of Eu²⁺ and the formation of impurity phases on the phosphor surface are effectively reduced. When the superficial organic carbon modified sample was treated in the 2 wt.% sucrose solutions, the relative brightness is strengthened by 2.15%, the thermal quenching characteristic is improved by 8.9% at 300℃, and the aging test results show an excellent thermal stability. All above indicate that the superficial organic carbon modification is a promising technique to enhance the thermal stability of analogous Eu²⁺-activated nirtide phosphors.     

An Artificial Autonomic Nervous System That Implements Heart and Pupil as Controlled by Artificial Sympathetic and Parasympathetic Nerves

The autonomic nervous system maintains homeostasis in organisms through complex neural pathways and responds adaptively to changes in the external and internal environment. The fabrication of an artificial autonomic nervous system is reported that replicates combined effects of sympathetic and parasympathetic nerves on cardiac activity and pupillary control, to mimic the regulation of autonomic nervous system to external changes. The artificial autonomic nerve-controlled pupil contraction and relaxation, modulating the rate of heartbeats for normal cardiac rhythm and arrhythmia as reflected by blink rates of a signal indicator. These functions are switched by using a parallel-channeled synaptic transistor with a special n-i-p heterostructure that has a 2D h-BN insulator in the middle to provide barrier against ion injection into the 2D MoS₂ bottom n-channel and enable short-term plasticity as induced by acetylcholine, and the electrochemical doping reaction occurred at the P3HT nanowire p-channels on top to enable relatively long-term plasticity as induced by noradrenaline. Low-energy consumption down to femtojoule and an ultrahigh paired-pulse facilitation index up to ≈455% are demonstrated. An artificial neural network based on device characteristics achieves a high recognition accuracy for electrocardiogram patterns. This study extends insights into artificial nerves-inspired biological signal processing and recognition.     

四氟硼酸二芳基碘鎓盐的合成及其表征

本文合成了四氟硼酸二芳基碘鎓盐阳离子紫外光引发剂，并且从红外、核磁、紫外光谱以及熔点测定进行了表征。结果表明，该合成方法的产率达58%，接近国外文献报道产率。     

磨削、研磨、喷丸处理对马氏体不锈钢疲劳强度的影响

通过对马氏体不锈钢(2Cr13)试片热处理强化处理后，分别进行了磨削后研磨加工、喷丸处理，以探讨表层硬度、表层残余应力及表面粗糙度等因素对疲劳强度的影响。实验表明，减少表面粗糙度Ra值，增加表层残余应力是提高2Cr13不锈钢使用寿命的有效方法。     

较大尺寸双排链轮的焊接结构改进

焊接链轮毛坯具有成本低、生产周期短的特点，但链轮结构影响焊接毛坯变形及强度。通过改进链轮毛坯的结构有效克服焊接所带来的负面影响，使得焊接链轮结构适应生产要求而得到广泛应用。     

Formulation,characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma

The objective of the present study is to formulate and characterize propranolol hydrochloride (PPL?·?HCl) gel, and to evaluate the efficacy of this formulation in transdermal treatment for superficial infantile hemangioma (IH). The transdermal PPL?·?HCl gel was prepared by a direct swelling method, which chose hydroxypropyl methylcellulose (HPMC) as the matrix and used terpenes plus alcohols as permeation enhancer. Permeation studies of PPL?·?HCl were carried out with modified Franz diffusion cells through piglet skin. Our results pointed to that among all studied permeation enhancers, farnesol plus isopropanol was the most effective combination (Q_24, 6027.4?±?563.1?μg/cm², ER, 6.8), which was significantly higher than that of control gel (p?相似文献