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排序方式: 共有1186条查询结果,搜索用时 46 毫秒
1.
Manjunatha S. Muttigi Byoung Ju Kim Bogyu Choi Inbo Han Hansoo Park Soo-Hong Lee 《International journal of molecular sciences》2020,21(23)
Adipose-derived mesenchymal stromal cells (Ad-MSCs) are a promising tool for articular cartilage repair and regeneration. However, the terminal hypertrophic differentiation of Ad-MSC-derived cartilage is a critical barrier during hyaline cartilage regeneration. In this study, we investigated the role of matrilin-3 in preventing Ad-MSC-derived chondrocyte hypertrophy in vitro and in an osteoarthritis (OA) destabilization of the medial meniscus (DMM) model. Methacrylated hyaluron (MAHA) (1%) was used to encapsulate and make scaffolds containing Ad-MSCs and matrilin-3. Subsequently, the encapsulated cells in the scaffolds were differentiated in chondrogenic medium (TGF-β, 1–14 days) and thyroid hormone hypertrophic medium (T3, 15–28 days). The presence of matrilin-3 with Ad-MSCs in the MAHA scaffold significantly increased the chondrogenic marker and decreased the hypertrophy marker mRNA and protein expression. Furthermore, matrilin-3 significantly modified the expression of TGF-β2, BMP-2, and BMP-4. Next, we prepared the OA model and transplanted Ad-MSCs primed with matrilin-3, either as a single-cell suspension or in spheroid form. Safranin-O staining and the OA score suggested that the regenerated cartilage morphology in the matrilin-3-primed Ad-MSC spheroids was similar to the positive control. Furthermore, matrilin-3-primed Ad-MSC spheroids prevented subchondral bone sclerosis in the mouse model. Here, we show that matrilin-3 plays a major role in modulating Ad-MSCs’ therapeutic effect on cartilage regeneration and hypertrophy suppression. 相似文献
3.
联合循环余热锅炉螺旋鳍片管烟气放热系数研究 总被引:1,自引:0,他引:1
东南大学建造了1座IGCC余热锅炉鳍片管受热面流动和传热热态试验装置,并先后在其上进行了2个不同螺旋鳍片管组的传热特性研究,通过分析比较实测的烟气侧对流放热系数与无量纲准则式计算的结果,得出了完全热模拟公式更为准确的结论。 相似文献
4.
5.
应用非线性kε湍流模式,采用非正交曲线坐标系下求解三维NS方程的非交错网格有限体积方法,数值模拟了充分发展条件下,三角形排列无限棒束间通道内,不同的几何参数(P/D),雷诺数(Re)下的流动和传热问题。给出了不同参数下的速度和温度分布以及湍流二次流动,分析了几何参数、雷诺数及二次流对棒束内流动和传热特性的影响,得到了不同参数下通道的摩擦系数和Nuselt数,并与经验关系式作了比较 相似文献
6.
Rouhollah Jalili Mohammad Morshed Seyed Abdolkarim Hosseini Ravandi 《应用聚合物科学杂志》2006,101(6):4350-4357
Electrospinning with a collector consisting of two pieces of electrically conductive substrates separated by a gap has been used to prepare uniaxially aligned PAN nanofibers. Solution of 15 wt % of PAN/DMF was used tentatively for electrospinning. The effects of width of the gap and applied voltage on degree of alignment were investigated using image‐processing technique by Fourier power spectrum method. The electrospinning conditions that gave the best alignment of nanofibers for 10–15 wt % solution concentrations were experimentally obtained. Bundles like multifilament yarns of uniaxially aligned nanofibers were prepared using a new simple method. After‐treatments of these bundles were carried out in boiling water under tension. A comparison was made between the crystallinity and mechanical behavior of posttreated and untreated bundles. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 4350–4357, 2006 相似文献
7.
管壳式换热器管束振动分析及防振措施 总被引:7,自引:0,他引:7
针对管壳式换热器常见的振动破坏形式 ,全面分析了管束振动的机理 ,并提出了相应的抗振措施 相似文献
8.
The forced convective heat transfer characteristics for incompressible power-law fluids past a bundle of circular cylinders have been investigated numerically. The cylinder-to-cylinder hydrodynamic interactions have been approximated via a simple cell model. The momentum and energy equations have been solved using a finite difference based numerical method for a range of physical and kinematic conditions. The role of the two commonly used thermal boundary conditions, namely, constant temperature or constant heat flux, on heat transfer characteristics has also been studied. Extensive numerical results elucidating the effect of shear-thinning viscosity on the values of Nusselt number have been obtained for Peclet numbers ranging from 1 to 5000, Reynolds number in the range 1-500, flow behaviour index 1?n?0.5 and three values of voidages, namely, 0.4, 0.5 and 0.6, typical of tubular heat exchangers and tube banks. Under all conditions, varying levels of enhancement in Nusselt number are observed due to shear-thinning behaviour. The surface averaged Nusselt number shows strong dependence on the values of voidage, power-law index, Reynolds and Peclet numbers. The paper is concluded by presenting comparisons with the scant experimental results available in the literature. 相似文献
9.
Alexander V. Bernstein Alexander P. Kuleshov 《International Journal of Software and Informatics》2013,7(3):359-390
One of the ultimate goals of Manifold Learning (ML) is to reconstruct an unknown nonlinear low-dimensional Data Manifold (DM) embedded in a high-dimensional observation space from a given set of data points sampled from the manifold. We derive asymptotic expansion and local lower and upper bounds for the maximum reconstruction error in a small neighborhood of an arbitrary point. The expansion and bounds are defined in terms of the distance between tangent spaces to the original DM and the Reconstructed Manifold (RM) at the selected point and its reconstructed
value, respectively. We propose an amplification of the ML, called Tangent Bundle ML, in which proximity is required not only between the DM and RM but also between their tangent spaces. We present a new geometrically
motivated Grassman & Stiefel Eigenmaps algorithm that solves this problem and gives a new solution for the ML also. 相似文献
10.
A new wet flue gas desulfurization method by reaction across the falling liquid film on the outside surface of axial finned-tube bundle and its principles of removal of SO2 are presented in this paper.The effects of different styles of tube bundle,and the pitch of tubes,flue gas velocity,gas-liquid ratio and flue gas temperature on desulphurization efficiency and the moisture content of flue gas are studied.The experiment results show that desulphurization effect is better for flue gas at 65℃,4.0m·s-1 against the tube bundle of 10 rows with relative pitch of staggered rows S1/d=2.1,S2/d=1.8. 相似文献