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1.
Mitsuo Miyazawa Hideki Kawazoe Mitsuro Hyakumachi 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2003,78(6):620-625
The microbial transformation of l‐menthol ( 1 ) was investigated by using 12 isolates of soil‐borne plant pathogenic fungi, Rhizoctonia solani (AG‐1‐IA Rs24, Joichi‐2, RRG97‐1; AG‐1‐IB TR22, R147, 110.4; AG‐1‐IC F‐1, F‐4, P‐1; AG‐1‐ID RCP‐1, RCP‐3, and RCP‐7) as a biocatalyst. Rhizoctonia solani F‐1, F‐4 and P‐1 showed 89.7–99.9% yields of converted product from 1 , RCP‐1, RCP‐3, and RCP‐7 26.0–26.9% and the other isolates 0.1–12.0%. In the cases of F‐1, F‐4 and P‐1, substrate 1 was converted to (?)‐(1S,3R,4S,6S)‐6‐hydroxymenthol ( 2 ), (?)‐(1S,3R,4S)‐1‐hydroxymenthol ( 3 ) and (+)‐(1S,3R,4R,6S)‐6,8‐dihydroxymenthol ( 4 ), which was a new compound. Substrate 1 was converted to 2 and/or 3 by RRG97‐1, 110.4, RCP‐1, RCP‐3 and RCP‐7. The structures of the metabolic products were elucidated on the basis of their spectral data. In addition, metabolic pathways of the biotransformation of 1 by Rhizoctonia solani are discussed. Finally, from the main component analysis and the differences in the yields of converted product from 1 , the 12 isolates of Rhizoctonia solani were divided into three groups based on an analysis of the metabolites. Copyright © 2003 Society of Chemical Industry 相似文献
2.
M.J. Seaton 《Computer Physics Communications》2002,146(2):225-249
The paper gives a review of the mathematical properties of the Coulomb radial wave functions, for attractive and repulsive potentials and for positive and negative energies, together with recommendations on best methods for their computation. It includes discussions of analytic continuations (complex energies, radial co-ordinates and angular momenta) and of relativistic Coulomb functions. 相似文献
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4.
建立了高放废液中~(147)Pm的测定方法。用HDEHP萃取稀土,再用HDEHP萃淋树脂柱分离AM和稀土。然后用高效液相色谱法将~(147)Pm从Eu、Ce等其它稀土中分离出来,用液体闪烁法测量~(147)Pm的放射性活度。 相似文献
5.
Jang Mi Han Jae Kyung Sohng Woo-Haeng Lee Tae-Jin Oh Hye Jin Jung 《International journal of molecular sciences》2021,22(5)
We recently discovered a novel nargenicin A1 analog, 23-demethyl 8,13-deoxynargenicin (compound 9), with potential anti-cancer and anti-angiogenic activities against human gastric adenocarcinoma (AGS) cells. To identify the key molecular targets of compound 9, that are responsible for its biological activities, the changes in proteome expression in AGS cells following compound 9 treatment were analyzed using two-dimensional gel electrophoresis (2-DE), followed by MALDI/TOF/MS. Analyses using chemical proteomics and western blotting revealed that compound 9 treatment significantly suppressed the expression of cyclophilin A (CypA), a member of the immunophilin family. Furthermore, compound 9 downregulated CD147-mediated mitogen-activated protein kinase (MAPK) signaling pathway, including c-Jun N-terminal kinase (JNK) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) by inhibiting the expression of CD147, the cellular receptor of CypA. Notably, the responses of AGS cells to CypA knockdown were significantly correlated with the anticancer and antiangiogenic effects of compound 9. CypA siRNAs reduced the expression of CD147 and phosphorylation of JNK and ERK1/2. In addition, the suppressive effects of CypA siRNAs on proliferation, migration, invasion, and angiogenesis induction of AGS cells were associated with G2/M cell cycle arrest, caspase-mediated apoptosis, inhibition of MMP-9 and MMP-2 expression, inactivation of PI3K/AKT/mTOR pathway, and inhibition of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression. The specific interaction between compound 9 and CypA was also confirmed using the drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA) approaches. Moreover, in silico docking analysis revealed that the structure of compound 9 was a good fit for the cyclosporin A binding cavity of CypA. Collectively, these findings provide a novel molecular basis for compound 9-mediated suppression of gastric cancer progression through the targeting of CypA. 相似文献
6.
矿用直流不间断电源的设计 总被引:1,自引:0,他引:1
设计了一种煤矿井下交换机用直流不间断电源。该不间断电源采用MAX713电源管理芯片对镍镉电池进行智能充电;采用MSP430F147单片机作为微处理器,利用外部中断方式监测矿用交流电的工作状态,当发现矿用交流电不能正常供电时对电路进行切换,启动镍镉电池供电,从而保证交换机持续工作。测试结果表明,该不间断电源具有一定的实用性。 相似文献
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8.
ZigBee无线网络技术在抄表系统中的应用 总被引:2,自引:1,他引:2
简单分析了现有自动抄表技术存在的问题,介绍了ZigBee技术的特点和优势,将ZigBee技术应用于自动抄表系统,提出了无线网络抄表系统方案.该方案利用TI公司的低功耗单片机MSP430F147作为核心处理器,使用Chipcon公司的射频芯片CC2420实现了数据无线收发通信.论述了系统的构成和工作原理,阐明了系统的硬件电路和软件设计.实践表明.把低成本、低功耗的无线zig-Bee技术应用于自动抄表系统,提高了系统应用的灵活性,同时也减少了抄表系统现场布线带来的各种问题. 相似文献
9.
Yang Bai Wan Huang Li-Tian Ma Jian-Li Jiang Zhi-Nan Chen 《International journal of molecular sciences》2014,15(4):6356-6377
Glycosylation of glycoproteins is one of many molecular changes that accompany malignant transformation. Post-translational modifications of proteins are closely associated with the adhesion, invasion, and metastasis of tumor cells. CD147, a tumor-associated antigen that is highly expressed on the cell surface of various tumors, is a potential target for cancer diagnosis and therapy. A significant biochemical property of CD147 is its high level of glycosylation. Studies on the structure and function of CD147 glycosylation provide valuable clues to the development of targeted therapies for cancer. Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147 N-glycans. Finally, we discuss proteins regulating CD147 glycosylation and the biological functions of CD147 glycosylation. 相似文献
10.