胸腺五肽辅助治疗肺癌对免疫功能影响及其疗效的系统评价

为了系统地评价胸腺五肽作为辅助药物治疗各种肺癌的疗效及其对机体免疫功能的影响，利用电子检索收集有关胸腺五肽联合放疗或化疗方案治疗肺癌的临床随机对照试验文献，对符合纳入标准的文献，采用RevMan5.3 软件进行系统评价。最终共纳入文献 9 篇，总样本量 784 例。Meta 分析结果表明，胸腺五肽作为辅助药物治疗各种肺癌提高总有效率的差异无统计学意义[OR ＝ 1.44, 95%CI(0.99, 2.10), P ＝0.06 ＞ 0.05]。在对免疫功能的影响方面，胸腺五肽的使用显著增高外周血中的 CD3+ 细胞水平[OR ＝ 5.88, 95% CI(2.34, 9.42), P ＝0.001]，CD4+ 细胞水平也显著上升[OR ＝8.32, 95%CI(5.22, 11.42), P ＜ 0.00001] , CD4＋ /CD8＋比值也有明显的提高[OR ＝ 0.38, 95% CI(0.18, 0.59), P＝0.0002]，但 CD8+ 细胞水平的差异无统计学意义[OR ＝－3.12, 95% CI ( －9.02, 2.79), P ＞0.05]。总的来说，本研究在一定程度上反映了在辅助治疗肺癌方面，胸腺五肽能显著提高外周血中的 CD3+ 细胞水平、CD4+ 细胞水平、CD4+/CD8+ 比值。而对于治疗的有效率、CD8+ 细胞水平，差异无统计学意义。     

Compiler compatible 5.66 Mb/mm2 8T 1R1W register file in 14 nm FinFET technology

1-read/1-write (1R1W) register file (RF) is a popular memory configuration in modern feature rich SoCs requiring significant amount of embedded memory. A memory compiler is constructed using the 8T RF bitcell spanning a range of instances from 32 b to 72 Kb. An 8T low-leakage bitcell of 0.106 μm² is used in a 14 nm FinFET technology with a 70 nm contacted gate pitch for high-density (HD) two-port (TP) RF memory compiler which achieves 5.66 Mb/mm² array density for a 72 Kb array which is the highest reported density in 14 nm FinFET technology. The density improvement is achieved by using techniques such as leaf-cell optimization (eliminating transistors), better architectural planning, top level connectivity through leaf-cell abutment and minimizing the number of unique leaf-cells. These techniques are fully compatible with memory compiler usage over the required span. Leakage power is minimized by using power-switches without degrading the density mentioned above. Self-induced supply voltage collapse technique is applied for write and a four stack static keeper is used for read Vmin improvement. Fabricated test chips using 14 nm process have demonstrated 2.33 GHz performance at 1.1 V/25 °C operation. Overall V_min of 550 mV is achieved with this design at 25 °C. The inbuilt power-switch improves leakage power by 12x in simulation. Approximately 8% die area of a leading 14 nm SoC in commercialization is occupied by these compiled RF instances.     

PLC的大型牵伸卷绕机的应用研究

本文介绍了大型牵伸卷绕机的计算机控制系统，以西门子MMV型变频器为驱动装置，西门子PLC300为控制核心，根据西门子USS协议和MPI协议，实现PLC与变频器、TP27触摸显示屏的通信，取得了较高的控制精度和稳定性，充分满足生产过程的需要，具有广阔的应用前景。     

基于Sql Server BI平台和决策树技术的CET-4成绩分析

文章首先对Sql Server 2008商业智能平台及决策树技术相关理论作了介绍,然后对挖掘数据源数据进行了一系列预处理。利用Sql Server 2008商业智能平台下的决策树技术并采用数据挖掘扩展语言即DMX语言创建了CET-4成绩分析决策树模型。分类矩阵和挖掘提升图分别对该模型的评估结果表明了模型具有较高的可靠性和分类准确度,同时模型对应的一些规则可作为英语教学管理和改革的重要参考依据。     

基于MVC模式的Web0A系统的设计与实现

为了方便企业的管理和提高协同办公效率,越来越多的企业采用了WebOA系统。针对传统设计模式开发的WebOA系统存在维护成本高、难以扩展等缺陷,文中提出一种基于MVC设计模式的系统开发方案。首先详细介绍了MVC模式的设计思想和ZendFramework的工作流程及原理,然后阐述了系统设计与实现的整个过程。该设计方案充分利用了MVC的结构和特点并已成功应用于某办公自动化系统的开发。实践表明,基于MVC模式开发的OA系统运行稳定,具有较好的灵活性和高效性,并且大大减少了系统的开发周期,达到了预期的效果。     

一种新型校园在线管理系统研究与开发

随着全球化进程的加快和网络技术的高速发展,高校多校区办学成为一种趋势,传统的信息管理系统已难以满足校园信息资源充分利用和高效管理的要求。针对此现状．研究B／S体系架构,使用Visual Studio2008、ASP．NET3．5、SQL Server2005等技术设计开发一种新型校园在线管理系统。系统主要包括用户登录及注销模块、大学管理员模块、校区管理员模块、教师模块、学生模块、权限管理模块等。     

有机磷灭蚊剂投放浓度和时间对水体总磷的影响

为分析新型低毒有机磷杀虫剂“1%双硫磷颗粒”投放对河道水质的影响,设置不同药剂投放浓度和不同反应时间的室内试验,以TP、NH₃-N及S^2-为目标因子,分析该药剂投放后水体污染物浓度。结果表明:不同试验组水样中S^2-质量浓度均小于0.02 mg/L,NH₃-N质量浓度处于0.029~0.036 mg/L之间,均达到地表水Ⅰ类标准;不同浓度药剂投放1 h后,水体TP质量浓度已达到稳定状态,且在60 h内均保持稳定,药剂投加量与水体TP质量浓度呈显著正相关(R²=0.85);不同处理组的药剂在水体中的TP释放量无明显差异,均在1.06~1.30 mg/g之间。“1%双硫磷颗粒”推荐适宜投放量不会使河道水质恶化到劣Ⅴ类,但增加药剂投放量会增加水体TP污染及富营养化风险。     

煤矿瓦斯监控系统关键数据加密算法的研究与实现

为了防止煤矿瓦斯监控系统中关键数据被篡改,保证数据安全,提出一种在SQL Server 2008数据库中利用对称加密算法对重要字段进行加密,并使用密钥和解密函数还原数据的方法。字段被对称加密后,任何对该字段数据的更改操作都需要得知密钥,并使用解密函数才能实现,从而有效地防止了对关键数据的非法操作,保护了敏感数据。实际应用证实了关键数据加密算法的有效性。     

TP63 Is Significantly Upregulated in Diabetic Kidney

The role of tumor protein 63 (TP63) in regulating insulin receptor substrate 1 (IRS-1) and other downstream signal proteins in diabetes has not been characterized. RNAs extracted from kidneys of diabetic mice (db/db) were sequenced to identify genes that are involved in kidney complications. RNA sequence analysis showed more than 4- to 6-fold increases in TP63 expression in the diabetic mice’s kidneys, compared to wild-type mice at age 10 and 12 months old. In addition, the kidneys from diabetic mice showed significant increases in TP63 mRNA and protein expression compared to WT mice. Mouse proximal tubular cells exposed to high glucose (HG) for 48 h showed significant decreases in IRS-1 expression and increases in TP63, compared to cells grown in normal glucose (NG). When TP63 was downregulated by siRNA, significant increases in IRS-1 and activation of AMP-activated protein kinase (AMPK (p-AMPK-Th¹⁷²)) occurred under NG and HG conditions. Moreover, activation of AMPK by pretreating the cells with AICAR resulted in significant downregulation of TP63 and increased IRS-1 expression. Ad-cDNA-mediated over-expression of tuberin resulted in significantly decreased TP63 levels and upregulation of IRS-1 expression. Furthermore, TP63 knockdown resulted in increased glucose uptake, whereas IRS-1 knockdown resulted in a decrease in the glucose uptake. Altogether, animal and cell culture data showed a potential role of TP63 as a new candidate gene involved in regulating IRS-1 that may be used as a new therapeutic target to prevent kidney complications in diabetes.     

Reforming of methane with carbon dioxide over supported bimetallic catalysts containing Ni and noble metal: I. Characterization and activity of SiO2 supported Ni–Rh catalysts

Cobalt catalysts supported on silica aerogel have been prepared using sol–gel chemistry followed by drying under supercritical ethanol conditions. Three different loadings of cobalt were synthesized: 2, 6, and 10% by weight. Transmission electron micrographs indicate that the metallic cobalt exists as discrete particles 50–70 nm in diameter for the 2 and 6% loadings. The 10% catalyst shows long needles of cobalt. BET and BJH measurements indicate that the catalysts retain the silica aerogel properties of high surface area (∼800 m²/g), large pore volume (∼5 cm³/g), and an average pore diameter in the mesoporous regime (∼25 nm). The catalysts were evaluated for Fischer–Tropsch activity in a laboratory-scale packed bed reactor. All three catalysts were active with the 10% Co catalyst achieving more than 20% CO conversion which corresponds to a rate of 1.53 g CO per g-cat per hour. The catalysts were selective for the C₁₀₊ hydrocarbons with more than 50% of the carbon contained within this fraction. A significant portion of the C₉–C₁₅ hydrocarbon product was observed as 1-olefins which reflects the enhanced mass transport within the very porous aerogel support.