N_2S_2或N_3S型配体的合成、~(99)Tc~m标记及生物分布研究

以MAG3为基本分子骨架，根据构效关系，分别引入合适的天然氨基酸，设计合成了4种N2S2或N3S型小分子多肽新配体，并通过了IR，^1H NMR,^13C NMR,MS谱学鉴定和元素分析表征。采用葡庚糖酸钙（GH）交换法对4个配体进行了^99Tc^m标记，研究了配合物在小鼠体内的生物分布特征。结果表明，^99Tc^m-MVGG肾摄取较高，滞留时间较长，血清除快，且肾与其它组织的活度比值高，具备成为肾功能显像剂的条件；^99Tc^m-MPGG肾初始摄取较高，R（肾／血）活度比值高，但肾清除较快，R（肾／肝）活度比值较低；^99Tc^m-MVTC和^99Tc^m－MPTC心肌初始摄取均较高，但在心肌和血中的清除速度较快。     

Using ion implantation to adjust the transition temperature of superconducting films

We summarize a continuing investigation into using ion implantation to alter the transition temperature of superconducting thin films. The primary motivation for the work presented here was to study the feasibility of using magnetic ion doping to replace the bi-layer T_c control process currently used for certain cryogenic detector applications at National Institute for Standards and Technology. The results from work with various ion species implanted into aluminum, molybdenum, titanium and tungsten host films are presented.     

EC与~（99m）Tc－GH之间的配体交换反应动力学研究

实验表明，ＥＣ浓度与配体交换反应速度常数无关，体系的ｐＨ值对速度常数和９９ｍＴｃ－ＥＣ的标记率影响较大。测定并计算了不同ｐＨ值的交换反应速度常数。结果表明，为保证用配体交换法制备９９ｍｃ－ＥＣ时９９ｍｃ－ＥＣ的标记率大于９０％，体系的ｐＨ值必须≥８。     

A study on sensitivity correction factor of gamma camera in whole body bone image

The aim of this study was to calculate a reasonable correction factor that could be corrected when the sensitivity of each gamma camera is measured and a whole body bone scan is performed as a follow-up examination. Seven pieces of equipment were used to analyse the sensitivity measurements of each gamma camera based on the source sensitivity measurement method recommended by the IAEA. These were BRIGHTVIEW, PRECEDENCE, ECAM, ECAM signature, ECAM Plus, SYMBIA T2 and INFINIA. The ^99mTc line source for the sensitivity measurement was generated in 4–7 kcps, which are the common values in a whole body bone scan. All the cameras were equipped with a low-energy and high-resolution parallel multi-hole collimator and set at a window width and photo peak of 15% and 140 keV, respectively. After placing the ^99mTc source as closely as possible to the collimator, the count was measured for 60 and 120 seconds to calculate correction factor. To determine if the correction factor calculated using the ^99mTc line source could be applied to a whole body bone scan of a real patient, a whole body bone scan was performed on 27 patients before applying the correction factor for comparative analysis. According to the experimental results using the ^99mTc line source, the gamma camera sensitivity was the highest for ECAM plus, followed in order by the gamma cameras, ECAM signature, SYMBIA T2, ECAM, BRIGHTVIEW, INFINIA and PRECEDENCE. When the results were used to calculate the correction factor based on the ECAM gamma camera, which had a medium-degree of sensitivity, the respective correction factors were 1·07, 1·05, 1·03, 1·00, 0·90, 0·83 and 0·72. The correction factors calculated based on the experiment using a ^99mTc line source were similar to those calculated based on the whole body bone scan. Clinical application of correction factor for measured sensitivity enables estimation of factor correction depending on difference in equipment when image is read, which improves accuracy and reliability of examination, and is expected to be used especially for continuous follow-up examination.     

磁助捕集分离制样/X射线荧光测量微量Tc

建立了磁助捕集分离制样(MASP)/X射线荧光分析微量Tc的方法,使用磁化树脂作为固相捕集剂捕集溶液中的锝,利用外加磁场快速分离制样,实现捕集、分离及制样同时完成,可直接使用X射线荧光测量样品Tc含量。研究并分析了反应时间、磁化树脂用量、液相体积及酸度等因素对测量的影响,给出了推荐测量分析流程。使用磁助捕集分离制样,对Tc的检出限为0.33mg/L,满足PUREX流程1AW工艺点测量Tc的要求。     

直接冷却中氮化铝与无氧铜低温真空接触热导的实验研究

以5W／20K小型G-M制冷机为冷源,对低温下氮化铝（AlN）与无氧铜（OFHC）界面的接触热导进行了实验研究和分析。在45～140K内,氮化铝／无氧铜界面接触热导随温度的升高而增大,同时亦随接触压力的增加而增大。实验中同时得到了氮化铝在低温下的热导率,随温度的升高,氮化铝热导率值逐渐增大。就氮化铝低温热导率及氮化铝／无氧铜接触界面热阻随温度变化规律进行了微结构机理分析。     

In situ observation of oxygen deficiency occurring during electron irradiation in high Tc superconductor YBa2Cu3Oy

The decreasing process of oxygen in YBa₂Cu₃O _y is investigated through high resolution electron microscopy (HREM) and convergent beam electron diffraction (CBED). Measurements of the axial length in HREM images show that oxygen content y decreases faster near a twin boundary than at the inner part of a twin lamella. The transformation from an orthorhombic to a tetragonal phase starts at a twin boundary and the transformed region propagates to an inner region of lamella. Lattice strains are observed near boundaries between transformed and non-transformed regions. The transformation is almost complete within 30 s during observation of HREM images at 400 kV and at room temperature. A value of y was quantitatively measured by analysing observed intensities of energy-filtered CBED patterns with the dynamical theory. The value of y decreases from 6.9 to 6.5 when 200 kV electrons are irradiated for 160 s in a microscope at 108 K. More precise analysis of the intensities provides information on charge distribution along the c -axis as well as local oxygen content at a spatial resolution of several nanometres.     

硅衬底上BSCCO高温超导材料的制备

研究了采用单靶控溅射在Ｓｉ（１００）衬底上生长ＹＳＺ（钇稳定的ＺｒＯ２）ＢＳＣＣＯ（铋锶钙铜氧）薄膜的工艺条件,包括生长温度,生长气氛,生长速率及氧化退化等。还研究了高温超导相的形成与生长温度的关系,并获得了超导膜临界温度为８２Ｋ的ＢＳＣＣＯ／ＹＳＺ／Ｓｉ兼容材料。     

组合式熔凝石英微透镜阵列-线列Yba_2Cu_3O_(7-δ)高温超导薄膜红外探测器的研究

采用准分子激光扫描消融法淀积YB32C23O7-δ高温超导薄膜,利用常规光刻工艺制备线列高温超导薄膜器件,采用离子束刻蚀制备与高温超导薄膜器件匹配的熔凝石英微透镜阵列,测试了微透镜／高温超导薄膜器件所构成的混合结构在1～5μm红外波段的几项重要的光响应特性．     

Integration of superconducting magnets with cryogen-free dilution refrigerator systems

There has been much recent research interest into “cryogen-free” dilution refrigerators. Cryogen-free systems have some advantages from a safety and convenience point of view as liquid cryogens are unnecessary. However, this also makes integrating the low-temperature system with a high magnetic field environment much more challenging. Here we shall describe recent successes of integrating superconducting magnets and dilution refrigerators into one system requiring a single pulse tube cooler. The resulting environment provides experimental temperatures between 7 mK and 30 K and magnetic fields up to 12 T. We shall describe the effects of AC loss heating in such systems on the pulse tube refrigerator when the field is ramped and also the effects of eddy current heating on the mixing chamber in sweeping fields.