药物相互作用研究在新药研发和审评决策中的应用

药物相互作用改变了剂量效应关系，可能会降低疗效或增加毒性，是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义，体内和体外研究的主要内容；梳理分析了2020年国家药品监督管理局（National Medical Products Administration, NMPA）和美国食品药品监督管理局（Food and Drug Administration, FDA）批准上市的新药药物相互作用研究情况，旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。     

Animations showing Lego manipulative tasks: Three potential moderators of effectiveness

Evidence suggests that transient visual information, such as animations, may be more challenging to learn than static visualizations. However, when a procedural-manipulative task is involved, our evolved embodied cognition seems to reverse this transitory challenge. Hence, for object manipulative tasks, instructional animations may be more suitable than statics. We investigated this argument further by comparing animations with statics using a Lego task shown to university students, by examining three potential moderators of effectiveness: (a) the environment of manipulation (virtual or physical), (b) the quality of visual information (focused or unfocused), and (c) the presence of hands (no hands or with hands). In Experiment 1 we found an advantage of animation over statics, and no differences among the environments. In Experiment 2, we again observed an animation advantage, a small advantage of focused static information compared to unfocused static information, and a positive effect of not showing the hands.     

面向消费类电子产品的自动化生产线成组技术

针对现代消费类电子产品快速更新换代的现状, 介绍了该类产品的自动化生产线成组技术,阐述了通过度量消费类电子产品相似性和派生性特征,对产线进行成组编码的原理,研究产线工位单元的建模方法,描述了建模内容,并通过有无装载板的产线结构,论述了产线成组编码集成的途径和方法.     

Expressive Facial Gestures From Motion Capture Data

Human facial gestures often exhibit such natural stochastic variations as how often the eyes blink, how often the eyebrows and the nose twitch, and how the head moves while speaking. The stochastic movements of facial features are key ingredients for generating convincing facial expressions. Although such small variations have been simulated using noise functions in many graphics applications, modulating noise functions to match natural variations induced from the affective states and the personality of characters is difficult and not intuitive. We present a technique for generating subtle expressive facial gestures (facial expressions and head motion) semi‐automatically from motion capture data. Our approach is based on Markov random fields that are simulated in two levels. In the lower level, the coordinated movements of facial features are captured, parameterized, and transferred to synthetic faces using basis shapes. The upper level represents independent stochastic behavior of facial features. The experimental results show that our system generates expressive facial gestures synchronized with input speech.     

烃氧化产物皂化后活性组分在油、水相的分配

用强酸酸化后测定乙醚抽出物酸量和酯量、溴甲酚绿两相滴定测定羧酸盐等方法研究了烃氧化产物皂化后活性组分在油、水相的分配。结果表明,在现行的用NaOH皂化烃氧化产物以制备水溶性石油磺酸盐的过程中有相当多的活性组分分配到油相;在水相和油相中均有大量羧酸酯存在,羧酸酯量远远超过羧酸盐量。     

无荧光防塌降失水剂KH－931的合成与性能

ＫＨ－９３１是以褐煤、丙烯酰胺、丙烯腈为原料制得的无荧光防塌降失水剂。本文简介了ＫＨ－９３１的合成条件，并对ＫＨ－９３１的防塌作用与降滤失作用进行了室内评定。实验结果表明，ＫＨ－９３１的防塌、降失水效果良好，并具有加量少、无荧光的特点。腐殖酸衍生物，降滤失剂，页岩抑制剂，多功能钻井液处理剂，荧光性，实验室研究     

排序聚类分析算法在派生式CAPP系统中的应用及实现

利用零件的相似性原理对零件分组是派生式CAPP系统的重要内容,对零件的分组是否合理,直接影响到派生式CAPP系统能否正常运行。阐述了排序聚类分析算法在生产流程分析法中的工作原理,分析了利用该算法实现零件分组的实现过程,并用示例验证了该算法。     

Simulation of Facial Muscle Actions Based on Rational Free Form Deformations

This paper describes interactive facilities for simulating abstract muscle actions using Rational Free Form Deformations (RFFD). The particular muscle action is simulated as the displacement of the control points of the control-unit for an RFFD defined on a region of interest. One or several simulated muscle actions constitute a Minimum Perceptible Action (MPA), which is defined as the atomic action unit, similar to Action Unit (AU) of the Facial Action Coding System (FACS), to build an expression.     

三维动画表演教学研究——浅析动画表演中角色动作与角色情感性格

随着科技的发展,数字动画及影视特技特效越来越被广泛应用,三维动画作为新兴科技、艺术、技术和表演的综合体,被广泛应用在虚拟现实中。动画师作为动画角色的创作者表演有着至关重要作用。在动画创作过程中,要使动画师能够抓住角色的性格,必须亲身体验角色表演的整个过程,抓住角色的肢体语言动作与角色的情态特征,使所创作的角色更加鲜活。     

三维动画表演教学研究——浅析动画表演在三维动画教学以及动画创作中的重要性

影视表演艺术学被广泛应用在电影电视以及舞台戏剧中,动画艺术作为电影艺术的一个分支,表演艺术也随之融入到三维动画创作中。动画表演为动画师创作鲜活的角色提供丰富的创作灵感。由于计算机图形学飞速发展,极大简化了动画艺术的制作流程,在三维动画中应用表演理论及艺术方法会极大完善角色的肢体行为,使动画师深入理解角色动作行为及把握角色性格,表现出鲜活的角色形象。