油田放射性作业人员外周血淋巴细胞染色体畸变的观察

本文调查了油田212例受γ射线和中子混合辐射照射的作业人员和30例正常人的外周血淋巴细胞染色体畸变。作业人员受γ射线照射的人均年受照剂量为1.28mGy。调查结果表明,放射性测井人员与正常人相比染色体畸变率有显著差异。     

V. Yeast sequencing reports. Identification of a gene encoding a new Ypt/Rab-like monomeric G-protein in Saccharomyces cerevisiae

A Saccharomyces cerevisiae sequence cloned by serendipity was found to encode a protein that is a new member of the Ypt/Rab monomeric G-protein family. This sequence shows high homology to the yeast genes SEC4 and YPT1 and, like SEC4 and YPT1, is essential for viability. The sequence was localized to chromosome V based upon hybridization to pulse-field gel-separated yeast chromosomes. The sequence has been deposited in the GenBank data library under Accession Number L17070.     

On-line free-flight path optimization based on improved genetic algorithms

Free flight (FF) is the ideal strategy of current investigations on air traffic management systems, where an on-line flight path optimization algorithm is of top importance. This paper proposes an innovative algorithm with potential real-time properties for FF path optimization, by using an improved genetic algorithm (GA). Two kinds of mathematical models for the on-line flight path optimization problem are proposed to cover the near and far future applications. Several improvements are introduced to the GA to speed up its convergence as well as to improve performance. Simulation results show that the new algorithm is effective and has potential to solve the on-line FF path optimization problem in real time.     

Analysis of human chromosome classification using centromere position

Automated homologous classification of human chromosomes from the metaphase spread of a cell is an essential task to identify various genetic disorders. Karyotyping is the process of visualizing and categorizing the chromosomes within a cell. It is very important to have a good feature extraction scheme for proper chromosome classification. Chromosome classification is performed by identifying the morphological features which mainly include the centromere location. The parameter is essential for classification which helps in determining a karyogarm. In this paper, a comparative analysis of two algorithms for identification of centromere position is done. The two approaches make use of the Medial Axis Transformation and Projection Vector. The analysis helps us to identify the algorithm that performs better in the identification of centromere position. The projection vector approach performs well in obtaining the centromere location in the chromosome with an efficiency of 90%.     

14.8MeV单能中子所致染色体畸变的剂量-效应关系

采用14.8 MeV单能中子对3名健康成人外周血进行照射,照射剂量分别为0、0.1、0.3、0.6、1.0、2.0、3.0、4.0Gy,观察淋巴细胞染色体畸变情况,建立本实验室染色体畸变与受照剂量的剂量-效应关系.实验结果表明:双着丝粒体+环状体数、无着丝粒体数、总畸变数、畸变细胞率与中子剂量均存在良好的线性关系,回归方程分别为Ydic+r=0.0291+0.0607(r2=0.986)、Yace=0.0124+0.1411D(r2=0.982)、Ya=0.0434+0.2035(r2=0.989)、Yac=0.0362+0.0475D(r2=0.927).     

染色体畸变分析作为生物剂量测定方法的研究概况

本文叙述了染色体畸变分析作为生物剂量计的国内外研究概况。文中较详细地介绍了离体照射诱发染色体畸变的剂量-效应关系及其在事故受照人员剂量估算中的应用状况,对局部照射和分次照射条件下确定剂量-效应关系的有关问题进行了分析,对今后研究动向作了简要讨论。     

8MeV X线照射人外周血诱发的染色体畸变率及其相对生物效应

本文应用国产 DZY-10医用电子直线加速器产生的8MeVX 线离体照射人外周血,经54小时培养后,观察淋巴细胞的染色体畸变,双着丝点体畸变率与剂量之间关系适宜配成 Y=(1.97±1.95)×10~(-4)D+(2.74±0.71)×10~(-6)D~2。以180kVX 线诱发的双着丝点体的畸变率为标准,得到8MeVX 线、~(60)Coγ线和14MeV 中子的相对生物效应系数分别为0.59、0.63和2.03。     

稳定性染色体畸变在远期辐射效应研究中的应用

染色体畸变分析可作为一种估算受照剂量的生物学方法,或作为指标用来评价辐射损伤。在各类染色体畸变中,以双着丝点和环较易识别,且在正常人群中极为罕见,故常被用作观察指标。但此类染色体畸变(即双着丝点或环)是不稳定的,随着受照后时间的延长,畸变率逐渐减低。这是因为含有非稳定性畸变的细胞,其结构上的缺陷,可使细胞分裂过程受到阻     

Iterative Contextual Recurrent Classification of Chromosomes

Recurrent connectionist models provide a method to represent dynamic patterns in a neural network. In this work we present a method for chromosome classification based on an almost unexplored neural network technique for this task. A partially recurrent connectionist model, the Elman network, is managed to capture the dark and light band patterns of the different classes. The proposed method is completed with the formulation of the ICC (iterative contextual classification) algorithm in order to restrict the classification to the cell context, and is applied to the neural network results. The Copenhagen data set was used in the experiments, where a cross-validation method was applied in order to obtain statistically representative results using the complete corpus. The entire system obtained very good results for this task, improving the performance of other neural network approaches.     

优化的遗传算法在游戏编程中的应用

本文简要介绍了游戏编程中的人工智能问题,基本遗传算法的实现原理及过程,分析了基本遗传算法的不足之处,重点介绍对基本遗传算法三个方面的优化及优化后的遗传算法具体的处理过程.