Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study

Severe periodontitis is prevalent in Down syndrome (DS). This study aimed to identify genetic variations associated with periodontitis in individuals with DS. The study group was distributed into DS patients with periodontitis (n = 50) and DS patients with healthy periodontium (n = 36). All samples were genotyped with the “Axiom Spanish Biobank” array, which contains 757,836 markers. An association analysis at the individual marker level using logistic regression, as well as at the gene level applying the sequence kernel association test (SKAT) was performed. The most significant genes were included in a pathway analysis using the free DAVID software. C12orf74 (rs4315121, p = 9.85 × 10⁻⁵, OR = 8.84), LOC101930064 (rs4814890, p = 9.61 × 10⁻⁵, OR = 0.13), KBTBD12 (rs1549874, p = 8.27 × 10⁻⁵, OR = 0.08), PIWIL1 (rs11060842, p = 7.82 × 10⁻⁵, OR = 9.05) and C16orf82 (rs62030877, p = 8.92 × 10⁻⁵, OR = 0.14) showed a higher probability in the individual analysis. The analysis at the gene level highlighted PIWIL, MIR9-2, LHCGR, TPR and BCR. At the signaling pathway level, PI3K-Akt, long-term depression and FoxO achieved nominal significance (p = 1.3 × 10⁻², p = 5.1 × 10⁻³, p = 1.2 × 10⁻², respectively). In summary, various metabolic pathways are involved in the pathogenesis of periodontitis in DS, including PI3K-Akt, which regulates cell proliferation and inflammatory response.     

针对Naive Scaler的改进

决策表离散化要求决策表中原有的分类结果不变,而NaiveScaler算法在离散化时,有些根据不可分辨关系应该得到的断点很可能被丢掉,造成决策表信息的丢失.针对这一问题,对其进行了研究并改进.原算法在扫描相同条件属性值而决策值不同的对象时,由于这些对象的排序不同可能造成离散的结果不同.主要是在这里某些断点可能被遗漏,并引进新的冲突.为此,当条件属性值变化时查看其决策属性值,若有不同决策属性值则追加断点以消除断点被丢掉的可能.进而使得到的初始断点集更可靠.最后给出实例表明该算法有效.     

软件无线电中前端数字下变频的研究

本文在讨论软件无线电的基本原理、结构、特点以及关键技术的基础上,研究了软件无线电数字前端中的数字下变频(DDC)技术。     

超细羽绒粒子对三种不同染料吸附动力学研究

采用超细粉体加工技术制备了超细羽绒粒子,并对其粒径、孔结构等进行了表征。将制备的超细羽绒粒子应用于染料废水的处理,研究其对模拟染料废水溶液中酸性大红3R、直接耐酸大红4BS、还原大红R的吸附性能。结果表明：超细羽绒粒子的平均粒径是2．34±0．26um,且具有良好的孔结构,其中以大孔为主,而且孔径分布较宽。动力学研究结构表明伪二级动力学方程可更好地描述超细羽绒粒子对酸性大红3R、直接耐酸大红4BS、还原大红R染料的吸附行为。     

顺序输送粘度差对混油量影响分析

针对两种不同粘度的后行柴油分别与同一种前行汽油顺序输送时存在的混油问题,借助CFD模拟仿真软件,建立了三维流动传质耦合模型。模拟计算结果表明,前行油品与后行油品的粘度差对顺序输送时的沿程混油量有显著影响。由横向混油截面的变化情况来看,混油初期后行柴油以弓形前锋曲面嵌入到前行油品中,运行30s其前锋曲面逐渐变尖且以锥形曲面向前行油品逐渐延伸;从纵向混油截面的变化情况来看,截面柴油以楔形前锋曲面从管道下部嵌入前行油品中;管道侧面、顶面和底面边界层区域的混油量均随粘度差的增大而减小,且底面边界层区域的混油量最大。     

基于PLC的香烟包装生产线的控制

本文介绍了香烟包装生产线的工艺流程,研究PLC在香烟包装控制系统中的应用、系统的组成与系统的硬件配置,以及上位机与PLC的通讯软件设计方法和香烟小包装控制部分的PLC工作流程图。     

论OLAP的三种实现技术

OLAP(On-LineAnalyticalProcessing)是数据仓库系统的主要应用,它支持复杂的分析操作,侧重决策支持。文章从数据的存储方式,钻取操作,数据更新,和性能上研究了OLAP的三种实现技术ROLAP(RelationalOLAP),MOLAP(MultidimensionalOLAP)HO-LAP(HybridOLAP)的不同和三种实现技术的适用范围。     

Correlations between jointing and seismic velocities in highly fractured rock masses

The paper presents the results of a study of heavily fractured calcareous rock masses outcropping in southern Italy based on both the unidimensional joint frequency (Nl) and rock quality designation (RQD) of rock cores and seismic velocity data from laboratory and down-hole tests. The in situ longitudinal wave velocities (v) were always very low and were correlated with both Nl and RQD. Between 1 and 2 km/s, small increases in velocity were associated with a considerable decrease in Nl and significant increase in RQD value. A velocity of 1.22 km/s corresponded to an RQD value of 0. The study indicated that the simple correlation proposed by the International Society for Rock Mechanics to evaluate the RQD from the unidimensional joint frequency can underestimate the results for heavily fractured rock masses, but that good correlations can be obtained between RQD and seismic velocity. Electronic Publication     

高光谱空间降采样独立成分特征分离

提出一种空间降采样独立成分特征分离方法,用于缩短独立成分分析(ICA)法在高光谱图像特征分离时的运算时间。该方法通过对高光谱图像的二维像素空间进行网格划分得到较小的窗口;基于光谱相似性测度法度量每个窗口中中心像素与周围像素的距离。然后舍弃这段距离小于阈值的周围像素,而将大于阈值的周围像素和中心像素作为样本量进行FastICA,获取投影矩阵变换原始数据,得到特征分离的ICA成分。对比了传统ICA与空间降采样(SDS)ICA(SDS_ICA)的性能,研究了降采样阈值参数、降采样窗口参数及初始投影矩阵对SDS_ICA特征分离性能及运行时间的影响。实验结果表明:应用SDS_ICA时,仅设置适中的阈值和不敏感的窗口大小参数,就能保持与传统ICA相近的特征分离性能,运行时间减少了30%以上。该方法适合应用于高光谱准实时特征提取、数据降维及目标探测等领域。