Rotating flow within a droplet actuated with AC EWOD

Electrowetting-on-dielectric (EWOD) is now used in numerous microsystems like digital lab-on-chips. This paper deals with a characteristic hydrodynamic flow appearing in droplets actuated by EWOD with AC voltage. In the coplanar electrode configuration, two pairs of vortex flows are observed to form in a droplet centred on the electrode gap. All experiments are performed in oil as ambient phase and flows in the droplet are analysed using fluorescent beads. At the same time, droplet oscillations induced by AC EWOD are also revealed under stroboscopic lighting. These experiments show that vortex location can be controlled by frequency actuation with fair degree of reproducibility.     

Digital microfluidic design and optimization of classic and new fluidic functions for lab on a chip systems

This paper deals with microfluidic studies for lab-on-a-chip development. The first goal was to develop microsystems immediately usable by biologists for complex protocol integrations. All fluid operations are performed on nano-liter droplet independently handled solely by electrowetting on dielectric (EWOD) actuation. A bottom-up architecture was used for chip design due to the development and validation of elementary fluidic designs, which are then assembled. This approach speeds up development and industrialization while minimizing the effort in designing and simplifying chip-fluidic programming. Dispensing reproducibility for 64 nl droplets obtained a CV below 3% and mixing time was only a few seconds. Ease of the integration was demonstrated by performing on chip serial dilutions of 2.8-folds, four times. The second part of this paper concerns the development of new innovative fluidic functions in order to extend EWOD-actuated digital fluidics’ capabilities. Experiments of particle dispensing by EWOD droplet handling are reported. Finally, work is shown concerning the coupling of EWOD actuation and magnetic fields for magnetic bead manipulation.     

Simplified dynamical model for optical response of electrofluidic displays

In this work we analyze the switching behavior of an electro-fluidic pixel in separate stages. For ‘on’ switching we consider the motion leading to oil film rupture (initiation stage), fast oil-dewetting and a slower droplet rearrangement stage. For ‘off’ switching we consider fast oil wetting and surface reforming to the flat (dark) state. A dynamic model derived from an overall energy balance analysis has been employed to describe the optical response inside an electrofluidic display (EFD) pixel for the oil dewetting and wetting stages. By comparison with the experimental electro–optic response data, the accuracy and shortcomings of this model can be illuminated. The optical response asymmetry between on and off-switching and optical response delay during the on-switching process are well described and explained. In addition, the liquid film reforming dynamics and electrohydrodynamic instability analysis are used to estimate the oil film rupture and film reforming times very well. This study provides a straightforward approach to describe the complicated electrofluidic switching dynamics inside an EFD pixel, which may guide the further optimization of EFD device design and driving schemes.     

Fabrication of AD/DA microfluidic converter using deep reactive ion etching of silicon and low temperature wafer bonding

The purpose of this work is to describe an original process that has been designed for the fabrication of a microfluidic converter. The fabrication is based on deep reactive ion etching of silicon and low temperature full wafer adhesive bonding. The technology development includes an improvement of the bonding process in order to produce an adaptive strength of SU-8 bond which not only ensures absence of debonding failures during the silicon deep etching procedure and the subsequent dicing procedure, but also avoids the potential SU-8 overflow leakage into channels due to the bonding step. Besides, the originality of the work is not only in the process but also in the design of the device. Common actuation method for microfluidic system is either based on closed-channel continuous-flow microfluidic (CMF) or droplet-based microfluidic (DMF). Both of them have advantages and disadvantages, and their integration on a single system is in dire need. In this paper, we briefly discuss the concept of microfluidic converter, integrating CMF with DMF, which can: (i) continuously preload reagents, (ii) independently manipulate several droplets, (iii) recombine and export samples into closed-channel continuous flow, making it ideal for interfacing to liquid-handling instruments and micro-analytical instruments.     

Convection heat transfer in electrostatic actuated liquid droplets for electronics cooling

In this paper, the internal flow and heat transfer inside the electrostatic actuated droplets are studied for different droplet velocities by means of detailed flow computations. It is shown that the internal droplet flow exhibits a parabolic characteristic at one hand and that the presence of two convection cells decreases the heat transfer to the lower part of the droplet, thereby limiting the overall heat transfer through the droplet. A typical enhancement of the heat transfer with a factor 2 is achieved with respect to the minimal value that would be obtained assuming heat conduction as the only means of heat transfer in the liquid. Further an analytic lumped model is presented to estimate the transient average droplet temperature with an accuracy of 5% compared to the full transient computational fluid dynamics modelling.     

Screen-printing fabrication of electrowetting displays based on poly(imide siloxane) and polyimide

We report a screen-printing fabrication process for large area electrowetting display (EWD) devices using polyimide-based materials. The poly(imide siloxane) was selected as hydrophobic insulator layer, and relatively hydrophilic polyimide as grids material. EWD devices that use poly(imide siloxane) as hydrophobic insulator fabricated with conventional methods showed good and reversible electrowetting performance on both single droplet level and device level, which showed its potential application in EWDs. The compatibility of polyimide-based materials (hydrophobic poly(imide siloxane) and hydrophilic polyimide) guarantee the good adhesion between two layers and the capability of printable fabrication. To this end, the hydrophilic grids have been successfully built on hydrophobic layer by screen-printing directly. The resulting EWD devices showed good switch performance and relatively high yield. Compared to conventional method, the polyimide-based materials and method offer the advantages of simple, cheap and fast fabrication, and are especially suitable for large area display fabrication.     

Wetting of polarized materials by molten carbonate

This paper presents a summary of our recent work on wetting of polarized materials by molten carbonate, also termed “electrowetting”. Electrowetting is here defined as wetting of conducting materials by ionic liquids under conditions of Faradaic reaction, that is, current load. Our recent work has focused on three issues of practical importance: (1) the effect of alkaline-earth (Ca, Sr, Ba) additions to simple alkali carbonate eutectics with respect to the wetting characteristics of the melt; (2) the driving force behind the meniscus movement of molten carbonate at electrodes under polarization; (3) the effect of changes in wetting characteristics such as caused by alkaline-earth addition on molten carbonate fuel cell (MCFC) performance. These three issues are briefly summarized by means of a few key experimental and computational results, with reference to more detailed communications now in process of publication.     

Optimization of the dielectric layer for electrowetting on dielectric

In this work the minimum actuation voltage V_min for droplet actuation with electrowetting on dielectric (EWOD) is analyzed. At first, the theoretical background of drop transport with EWOD is shown. Then the impact of thin dielectric films deposited with atomic layer deposition (ALD) and super-hydrophobic layers on the minimum required actuation voltage for drop transport are presented. To this, contact angles are measured on both Al₂O₃ and fluorinated DLC each with a drop of water. For verify the hypothesis, the analytically calculated values for the minimum actuation voltage V_min are compared with numerical simulation results using COMSOL Multiphysics^®. The results show that the actuation voltage value from the simulation is lower than calculated analytically.     

Low-cost,rapid-prototyping of digital microfluidics devices

An innovative and simple microfabrication method for digital microfluidics is presented. In this method, devices are formed from copper substrates or gold compact disks using rapid marker masking to replace photolithography. The new method is capable of forming devices with inter-electrode gaps as small as 50 μm. Saran™ wrap (polyethylene film) and commercial water repellants were used as dielectric and hydrophobic coatings, respectively, to replace commonly used and more expensive materials such as parylene-C and Teflon-AF. Devices formed by the new method enabled single- and two-plate actuation of droplets with volumes of 1–12 μL. Fabricated devices were successfully tested for droplet manipulation, merging and splitting. We anticipate that this fabrication method will bring digital microfluidics within the reach of any laboratory with minimal facilities. Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.     

Electrostatic force calculation for an EWOD-actuated droplet

This paper examines the electrostatic force on a microdroplet transported via electrowetting on dielectric (EWOD). In contrast with previous publications, this article details the force distribution on the advancing and receding fluid faces, in addition to presenting simple algebraic formulae for the net force in terms of system parameters. Dependence of the force distribution and its integral on system geometry, droplet location, and material properties is described. The consequences of these theoretically and numerically obtained results for design and fabrication of EWOD devices are considered.