吴茱萸碱对人结肠癌lovo细胞生长的抑制作用

目的探讨吴茱萸碱(Evodiamine,Evo)在体内外对人结肠癌lovo细胞生长的抑制作用及其机制。方法采用MTT法检测Evo对人结肠癌lovo细胞、人乳腺癌MDA-MB-231细胞以及人肺癌A549细胞生长的影响;流式细胞术分析Evo对lovo细胞细胞周期和细胞凋亡的影响;采用Evo治疗lovo细胞荷瘤裸鼠,并绘制肿瘤生长曲线;Westernblot法检测Evo对lovo细胞和肿瘤组织中Bcl-2及procaspase-3表达的影响。结果 Evo能抑制lovo细胞生长(P<0.01),促进MDA-MB-231细胞增殖(P<0.01),对A549细胞无明显作用(P>0.05);可将lovo细胞阻滞于S期(P<0.01),并呈时间依赖性诱导其凋亡(P<0.01);能抑制lovo细胞荷瘤裸鼠肿瘤生长(P<0.05);Westernblot检测结果显示,Evo在体内外均可降低lovo细胞Bcl-2及procas-pase-3的表达。结论 Evo可通过抑制Bcl-2表达,激活caspase-3,诱导凋亡,从而抑制lovo细胞的生长。     

融合MCMC 方法的差分进化算法 在水文模型参数优选中的应用

传统差分进化算法在优选水文模型参数时容易出现"早熟收敛"问题,基于马尔可夫链蒙特卡罗方法的差分进化算法——DREAM算法,对嘉陵江流域降雨径流模型的参数优选问题进行了分析。结果发现,DREAM算法融合了自适应Metropolis方法的优点,能有效克服"早熟收敛"问题,适用于推求先验信息较少的复杂水文模型参数后验分布。     

Adaptive Knowledge in Architecture: A Few Notes on the Nature of Transdisciplinarity

New digital technologies allow unprecedented levels of collaboration across fields of expertise. The international transdisciplinary practice Open Source Architecture has been exploring the possibilities in this area for over ten years. Two of its cofounders, Aaron Sprecher and Chandler Ahrens , reflect on key related themes – intensity and extensity of information, and potentiality (or collaborative iteration) – through three of its projects.     

PET-POY设备改造生产167 dtex/288 f FDY工艺探讨

在现有的POY卷绕设备基础上,采用上海经纬提供的双热辊加热装置,TMT公司的预网络器、外置式主网络器,Barmag提供的外环吹EVO技术,生产167 dtex/288 f的FDY。重点讨论了双热辊温度、牵伸倍率、纺丝速度、网络压力等因素对产晶质量的影响,提出生产质量优良的多孔FDY设备改造及工艺措施。     

Latin America Meander: In Search of a New Civic Imagination

Teddy Cruz reviews the shifting political landscape of the last two decades in Latin America. Breaking from US dependency, the continent has charted an alternative course as municipalities have reconnected public policy, social justice and civic imagination. In order to address inequality, new models of urban development have been produced on sites of scarcity, and city mayors and administrations have been prepared to learn from each other through best practice. Copyright © 2011 John Wiley & Sons, Ltd.