Design of delayed reconfigurable manufacturing system based on part family grouping and machine selection

To improve the convertibility of reconfigurable manufacturing system (RMS), the concept of delayed reconfigurable manufacturing system (D-RMS) was proposed. RMS and D-RMS are both constructed around part family. However, D-RMS may suffer from ultra-long system problem with unacceptable idle machines using generic RMS part families. Besides, considering the complex basic system structure of D-RMS, machine selection of D-RMS should be addressed, including dedicated machine, flexible machine, and reconfigurable machine. Therefore, a system design method for D-RMS based on part family grouping and machine selection is proposed. Firstly, a part family grouping method is proposed for D-RMS that groups the parts with more former common operations into the same part family. The concept of longest relative position common operation subsequence (LPCS) is proposed. The similarity coefficient among the parts is calculated based on LPCS. The reciprocal value of the operation position of LPCS is adopted as the characteristic value. The average linkage clustering (ALC) algorithm is used to cluster the parts. Secondly, a machine selection method is proposed to complete the system design of D-RMS, including machine selection rules and the dividing point decision model. Finally, a case study is given to implement and verify the proposed system design method for D-RMS. The results show that the proposed system design method is effective, which can group parts with more former common operations into the same part family and select appropriate machine types.     

27例乙型血友病患者Ⅸ因子基因突变研究

采用ＰＣＲ（聚合酶链反应）及ＧＡＷＴＳ（ＧｅｎｏｍｉｃＡｍｐｌｉｆｉｃａｔｉｏｎｗｉｔｈＴｒａｎｓｃｒｉｐｔｓＳｅｑｕｅｎｃｉｎｇ）技术，研究了江苏、湖北、山东、广东、福建、宁夏六省区２７例乙型血友病患者及其家系成员ＦⅨ（九因子）基因各２．２Ｋｂ　ＤＮＡ序列。在２ｌ例中发现２０种不同类型的突变。其中１２种是未曾报道的新突变。３８％的突变发生在ＣｐＧ二核苷致序列上，进一步证实了ＣｐＧ确系突变热点。同时检出６例女性为致病基因携带者。对开展基因产前诊断及优生优育等，具有重要意义。     

Color Grouping in Space and Time: Evidence From Negative Color-Based Carryover Effects in Preview Search.

Five experiments addressed the role of color grouping in preview search (D. G. Watson & G. W. Humphreys, 1997). Experiment 1 used opposite color ratios of distractors in preview and second search displays, creating equal numbers of distractors in each color group in the final display. There was selective slowing for new targets carrying the majority color of the old items. This effect held when there was no bias in the preview and only the second search set had an uneven color ratio (Experiment 2). In Experiment 3, participants had foreknowledge of the target color, and effects were shown over and above those due to color biases. Experiment 4 demonstrated negative color carryover even when previews changed color. Experiment 5 showed reduced color carryover effects when previews were presented more briefly. Collectively, the results provide evidence for inhibitory carryover effects in preview search based on feature grouping. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perceptual primitives from an extended 4D Hough transform

Directional features extracted from Gabor wavelets responses were used to train a structure of self-organising maps, thus classifying each pixel in the image within a neuron-map. Resulting directional primitives were grouped into perceptual primitives introducing an extended 4D Hough transform to group pixels with similar directional features. These can then be used as perceptual primitives to detect salient structures. The proposed method has independently fixed parameters that do not need to be tuned for different kind or quality of images. We present results in application to noisy FLIR images and show that line primitives for complex structures, such as bridges, or simple structures, such as runways, can be found by this approach. We compare and demonstrate the quality of our results with those obtained through a parameter-dependent traditional Canny edge detector and Hough line finding process.     

Hydrogenases, accessory genes and the regulation of [NiFe] hydrogenase biosynthesis in Thiocapsa roseopersicina

The purple (Sulphur) phototrophic bacterium, Thiocapsa roseopersicina BBS contains several [NiFe] hydrogenases, of which two are membrane bound. Mutant T. roseopersicina cells, carrying deletions in both gene clusters showed hydrogenase activity. This activity was located in the cytoplasm. The structural gene cluster hoxEFUYH was identified and sequenced. In addition, genes homologous to hupUV/hoxBC, the hydrogen sensing hydrogenase have been identified and sequenced.Regulation of hydrogenase biosynthesis was studied in detail for HydSL (renamed HynSL). A random mutagenesis system was optimised for T. roseopersicina. One of the mutations was in a gene similar to that coding for the HypF proteins in other organisms. Inactivation of the hypF gene resulted in a 60-fold increase in hydrogen evolution under nitrogen fixing conditions. In addition to hypF, the following accessory genes were identified: hydD, hupK, hypC1, hypC2, hypDE. Characterisation of the corresponding gene products and search for additional accessory genes are in progress.     

Acceptability of genetically modified cheese presented as real product alternative

European consumers, in general, have negative attitudes towards the use of gene technology in food production. The objective of this study was to examine whether taste and health benefits influence the acceptability of genetically modified (gm) products when they are presented as real product alternatives. Consumers in Denmark, Finland, Norway and Sweden (n=738) assessed two cheeses: one was labelled as genetically modified (preferred in an earlier product test) and the other as conventional (neutral in an earlier product test). A smaller control group received two cheeses with blind codes. Labelling decreased consumers' intentions to buy the originally preferred gm-labelled cheese, but still the intentions were at the same level with the conventionally labelled option. Participants chose two gm cheeses out of five possible when given the option to take cheese home after tasting. Intentions to buy gm cheese could best be explained by respondents' attitudes towards gene technology and perceived taste benefits. General health interest was also a reinforcer of intentions for gm cheese with reduced fat content.     

辐射敏感综合症--AT病研究进展

共济失调性毛细血管扩张综合症(AT)是一种单基因突变引起的遗传性疾病，表现为高辐射敏感性、进行性神经退变、免疫缺陷、早衰及易患癌症等。本文综述了AT病的研究概况，包括AT临床症状、AT基因的定位、结构与功能、辐射对AT细胞信号传导的影响、AT基因组不稳定性及基因治疗。     

Incremental wrapper-based gene selection from microarray data for cancer classification

Gene expression microarray is a rapidly maturing technology that provides the opportunity to assay the expression levels of thousands or tens of thousands of genes in a single experiment. We present a new heuristic to select relevant gene subsets in order to further use them for the classification task. Our method is based on the statistical significance of adding a gene from a ranked-list to the final subset. The efficiency and effectiveness of our technique is demonstrated through extensive comparisons with other representative heuristics. Our approach shows an excellent performance, not only at identifying relevant genes, but also with respect to the computational cost.     

Soft computing approach to fault diagnosis of centrifugal pump

Fault detection and isolation in rotating machinery is very important from an industrial viewpoint as it can help in maintenance activities and significantly reduce the down-time of the machine, resulting in major cost savings. Traditional methods have been found to be not very accurate. Soft computing based methods are now being increasingly employed for the purpose. The proposed method is based on a genetic programming technique which is known as gene expression programming (GEP). GEP is somewhat a new member of the genetic programming family. The main objective of this paper is to compare the classification accuracy of the proposed evolutionary computing based method with other pattern classification approaches such as support vector machine (SVM), Wavelet-GEP, and proximal support vector machine (PSVM). For this purpose, six states viz., normal, bearing fault, impeller fault, seal fault, impeller and bearing fault together, cavitation are simulated on centrifugal pump. Decision tree algorithm is used to select the features. The results obtained using GEP is compared with the performance of Wavelet-GEP, support vector machine (SVM) and proximal support vector machine (PSVM) based classifiers. It is observed that both GEP and SVM equally outperform the other two classifiers (PSVM and Wavelet-GEP) considered in the present study.     

一种高效挖掘冠心病医案关联规则的仿真研究

研究中医冠心病医案,高效挖掘有益信息规则问题,由于中医医案数据量大、关联性强,针对传统的关联规则挖掘算法处理中医医案数据时存在效率低、收敛速度慢及漏报规则等问题,提出一种小生境技术和基因表达式编程相结合的挖掘关联规则的方法。通过惩罚函数设置支持度阈值,利用小生境技术执行小生境演化、融合算法,结合基因表达式编程算法操作简单、鲁棒性强的优势搜索强关联规则,有效避免了算法早熟,解决了规则冗余。针对治疗冠心病的中医医案进行了验证性实验,实验结果表明,改进算法在提取有效信息的效率上有较大的提高,挖掘结果对冠心病中医临床诊治具有一定的参考价值。