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排序方式: 共有66条查询结果,搜索用时 31 毫秒
1.
Mohammad Reza Aboudzadeh Zhu Jiawen Wu Bin 《Korean Journal of Chemical Engineering》2006,23(1):124-130
The equilibrium and kinetic characteristics of the adsorption of human serum albumin (HSA) and ovalbumin (OVA) to the DEAE
Sepharose FF weak anion exchanger were experimentally determined. The rate for protein adsorption was simulated with two different
models, the first being based on a single lumped kinetic parameter, while the second includes the individual mass transfer
processes occurring prior to the adsorption intervention, i.e., diffusion across the liquid film surrounding individual particles
and diffusion within the ion exchanger particle itself. The actual adsorption of OVA to DEAE Sepharose FF in fully mixed stirred
vessels and in packed bed columns was consistent with both models. In the case of HSA, however, the adsorption profile in
an agitated vessel was consistent only with the pore diffusion model and neither model could correctly predict the latter
part of the breakthrough profile observed in packed bed experiments. 相似文献
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Hasan Kouchakzadeh Seyed Abbas Shojaosadati Fazel Shokri 《Chemical Engineering Research and Design》2014
Herein, the poorly water-soluble drug, Tamoxifen (Tmx), was loaded in the amphipathic matrix of human serum albumin (HSA) nanoparticles by a modified desolvation method. In order to enhance the drug loading (DL) and drug entrapment efficiency (DEE) (<2% and 10%, respectively), ultrasonication of Tmx-HSA mixture was performed prior to desolvation process. Tmx loading and entrapment efficiency were optimized by employment of the response surface methodology (RSM)-central composite design (CCD) of experiments. Under the optimum conditions of 1.59 mg Tmx/ml concentration, 7.76 pH and 5 h incubation of HSA-Tmx, the DL of 6.7% and DEE of 74% are achievable. Particles with the average size of 195 nm, zeta potential of −21 mV and polydispersity index of 0.09 were produced under these conditions. A more sustained Tmx release behavior was observed from polyethylene glycol (PEG) conjugated nanoparticles in comparison to the non-PEGylated ones. The short-term stability investigation showed no alteration in physicochemical properties of nanoparticles at 4 and 37 °C, but small increase in nanoparticles size was observed after three months of storage at room temperature. This is the first report for efficient production of a Tmx delivery system based on HSA nanoparticles. 相似文献
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《国际聚合物材料杂志》2012,61(12):632-640
Taxol-loaded poly(lactic acid-co-glycolic acid) (PLGA) microspheres containing different portions of human serum albumin microparticles (mHSA) were prepared via an in situ forming method. mHSA was obtained using a freezing-induced phase separation method and further surface modified via PLGA chains (g-mHSA). Surface modification of mHSA improved their dispersion within microspheres. Incorporation of 3% mHSA within microspheres increased their size and surface porosity, while g-mHSA decreased their size. Addition of 1.5% and 3% mHSA into microspheres decreased their initial burst release from 40.7% to 21.1% and 10.2%, respectively. Microspheres consisting 1.5% and 3% g-mHSA displayed 29.9% and 33.1% initial burst release, respectively. 相似文献
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以咖啡酸、间羟基肉桂酸为母体,分别与止血芳酸反应,设计合成两种羟基肉桂酸衍生物I、II,并用MS、IR、1H-NMR、13C-NMR进行结构表征。采用荧光光谱法、同步荧光光谱法、紫外可见光谱法结合分子对接技术研究其在体外生理条件下与HSA之间的相互作用机制。光谱实验结果表明,衍生物I和II都可以使HSA的内源荧光发生静态猝灭,相互作用力主要是氢键和范德华力,且对HSA的构象产生一定的影响。分子对接结果表明衍生物I、II与HSA中的结合位于亚结构域IIA(即site I)中,作用力主要是氢键和范德华力,同时还存在着疏水作用,且衍生物距色氨酸残基(Trp214)很近,很好地解释了衍生物有效猝灭HSA内源荧光的实验现象。分子对接与实验获得了一致性的结果,二者相互作证,提高了实验结果推断的准确度。 相似文献
8.
Abderrahim Titi Mouslim Messali Rachid Touzani Mohammed Fettouhi Abdelkader Zarrouk Nabil Al-Zaqri Ali Alsalme Fahad A. Alharthi Amjad Alsyahi Ismail Warad 《International journal of molecular sciences》2020,21(22)
A new double-open-cubane core Cd(II)-O-Cu(II) bimetallic ligand mixed cluster of type [Cl2Cu4Cd2(NNO)6(NN)2(NO3)2].CH3CN was made available in EtOH/CH3CN solution. The 1-hydroxymethyl-3,5-dimethylpyrazole (NNOH) and 3,5-dimethylpyrazole (NNH) act as N,O-polydentate anion ligands in coordinating the Cu(II) and Cd(II) centers. The structure of the cluster in the solid state was proved by XRD study and confirmed in the liquid state by UV-vis analysis. The XRD result supported the construction of two octahedral and one square pyramid geometries types around the four Cu(II) centers and only octahedral geometry around Cd(II) two centers. Interestingly, NNOH ligand acts as a tetra-µ3-oxo and tri-µ2-oxo ligand; meanwhile, the N-N in NNH acts as classical bidentate anion/neutral ligands. The interactions in the lattice were detected experimentally by the XRD-packing result and computed via Hirschfeld surface analysis (HSA). The UV-vis., FT-IR and Energy Dispersive X-ray (EDX), supported the desired double-open cubane cluster composition. The oxidation potential of the desired cluster was evaluated using a 3,5-DTB-catechol 3,5-DTB-quinone as a catecholase model reaction. 相似文献
9.
马钢薄板坯连铸连轧是目前世界上最先进的热轧板卷生产线之一,其连铸机设计为4个扇形段,使用了液压液芯压下技术。该文重点介绍液压液芯压下系统组成、工作原理以及实践经验。 相似文献
10.
随着药物的普遍使用,研究药物与人血清白蛋白的作用机理不仅可了解药物的运输、代谢过程;而且对临床用药、药物设计、新药开发具有重要指导意义。文章综述了药物小分子与人血清白蛋白相互作用的研究手段。 相似文献