Response coding and visuomotor transformation in the Simon task: The role of action goals.

Manual responses can be defined by differing response parameters. Any of them may generate a Simon effect. For all those response parameters, the same implementation of the Simon effect (in terms of subserving mechanism) is assumed. In 3 experiments, subjects had to respond with either fingers or sticks. Temporal properties of the Simon effect changed with response parameters relevant in a task. The Simon effect for manual responses decayed. For stick responses, in which the action goal differed from the anatomical mapping of the acting hand, a sustained Simon effect was observed. However, if the action goal for stick responses was not instrumental for selecting the correct response, the Simon effect decayed. The findings are consistent with the notion of different mechanisms involved in generating a Simon effect. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

The mechanisms underlying the transport of leptin into the brain are still largely unclear. While the leptin receptor has been implicated in the transport process, recent evidence has suggested an additional role of LRP2 (megalin). To evaluate the function of LRP2 for leptin transport across the blood-brain barrier (BBB), we developed a novel leptin-luciferase fusion protein (pLG), which stimulated leptin signaling and was transported in an in vitro BBB model based on porcine endothelial cells. The LRP inhibitor RAP did not affect leptin transport, arguing against a role of LRP2. In line with this, the selective deletion of LRP2 in brain endothelial cells and epithelial cells of the choroid plexus did not influence bodyweight, body composition, food intake, or energy expenditure of mice. These findings suggest that LRP2 at the BBB is not involved in the transport of leptin into the brain, nor in the development of obesity as has previously been described.     

Interpolymer radical coupling: A toolbox complementary to controlled radical polymerization

The current review focuses on the relevance and practical benefit of interpolymer radical coupling methods. The latter are developing rapidly and constitute a perfectly complementary macromolecular engineering toolbox to the controlled radical polymerization techniques (CRP). Indeed, all structures formed by CRP are likely to be prone to radical coupling reactions, which multiply the available synthetic possibilities. Basically, the coupling systems can be divided in two main categories. The first one, including the atom transfer radical coupling (ATRC), silane radical atom abstraction (SRAA) and cobalt-mediated radical coupling (CMRC), relies on the recombination of macroradicals produced from a dormant species. The second one, including atom transfer nitroxide radical coupling (ATNRC), single electron transfer nitroxide radical coupling (SETNRC), enhanced spin capturing polymerization (ESCP) and nitrone/nitroso mediated radical coupling (NMRC), makes use of a radical scavenger in order to promote the conjugation of the polymer chains. More than a compilation of macromolecular engineering achievements, the present review additionally aims to emphasize the particularities, synthetic potential and present limitations of each system.     

<Emphasis Type="Bold">Plant Layout Computerised Design: Logistic and Relayout Program (LRP)</Emphasis>

Markets are affected by strong competition in terms of continuous innovation of products and processes, high customer satisfaction and low cost of production. In order to achieve these strategic results it is recommended, or necessary, to rectify lack of organisation. For instance, the increasing costs due to material handling, force factories to check the facility layout and, when necessary, to improve it. The evaluation of a prospective improvement requires a large effort and a well-established skill. The study and the optimisation of plant layout is a strategic activity. This paper represents the last step of a research program on the automatic design of plant layout. The aim is to support the design activity of plant layout by means of an integrated approach, taking into account many criteria, both quantitative and qualitative. In particular, this paper presents a global approach, based on material flow and activity relationships. It is carried out using new software, called LRP (layout and re-layout program), introduced by the authors. A real application in a factory, specialising in the production of electronic devices, is presented.     

Identification of Rare LRP5 Variants in a Cohort of Males with Impaired Bone Mass

Osteoporosis is the most common bone disease characterized by reduced bone mass and increased bone fragility. Genetic contribution is one of the main causes of primary osteoporosis; therefore, both genders are affected by this skeletal disorder. Nonetheless, osteoporosis in men has received little attention, thus being underestimated and undertreated. The aim of this study was to identify novel genetic variants in a cohort of 128 males with idiopathic low bone mass using a next-generation sequencing (NGS) panel including genes whose mutations could result in reduced bone mineral density (BMD). Genetic analysis detected in eleven patients ten rare heterozygous variants within the LRP5 gene, which were categorized as VUS (variant of uncertain significance), likely pathogenic and benign variants according to American College of Medical Genetics and Genomics (ACMG) guidelines. Protein structural and Bayesian analysis performed on identified LRP5 variants pointed out p.R1036Q and p.R1135C as pathogenic, therefore suggesting the likely association of these two variants with the low bone mass phenotype. In conclusion, this study expands our understanding on the importance of a functional LRP5 protein in bone formation and highlights the necessity to sequence this gene in subjects with idiopathic low BMD.     

震后过渡阶段应急物流系统的定位运输路线安排问题研究

针对震后过渡阶段中,回收救援物资与保护灾区环境的问题,在满足灾区民众基本生活需求的前提下,提出了一个正逆向结合的应急物流设施定位-运输路线安排问题(LRP)模型.首先,结合回收物资可分批运输的特点,建立以应急系统耗费总时间最小为目标函数的数学模型;然后,利用两阶段启发式算法对模型进行求解;最后,算例分析验证了模型和算法的可行性.实验结果表明,与传统单向LRP模型相比,所提方法的目标函数值减少了51%.所提模型能够有效提高应急物流系统运行效率,并为应急管理部门提供辅助决策支持.     

Activated Alpha-2 Macroglobulin Improves Insulin Response via LRP1 in Lipid-Loaded HL-1 Cardiomyocytes

Activated alpha-2 Macroglobulin (α₂M*) is specifically recognized by the cluster I/II of LRP1 (Low-density lipoprotein Receptor-related Protein-1). LRP1 is a scaffold protein for insulin receptor involved in the insulin-induced glucose transporter type 4 (GLUT4) translocation to plasma membrane and glucose uptake in different types of cells. Moreover, the cluster II of LRP1 plays a critical role in the internalization of atherogenic lipoproteins, such as aggregated Low-density Lipoproteins (aggLDL), promoting intracellular cholesteryl ester (CE) accumulation mainly in arterial intima and myocardium. The aggLDL uptake by LRP1 impairs GLUT4 traffic and the insulin response in cardiomyocytes. However, the link between CE accumulation, insulin action, and cardiac dysfunction are largely unknown. Here, we found that α₂M* increased GLUT4 expression on cell surface by Rab4, Rab8A, and Rab10-mediated recycling through PI₃K/Akt and MAPK/ERK signaling activation. Moreover, α₂M* enhanced the insulin response increasing insulin-induced glucose uptake rate in the myocardium under normal conditions. On the other hand, α₂M* blocked the intracellular CE accumulation, improved the insulin response and reduced cardiac damage in HL-1 cardiomyocytes exposed to aggLDL. In conclusion, α₂M* by its agonist action on LRP1, counteracts the deleterious effects of aggLDL in cardiomyocytes, which may have therapeutic implications in cardiovascular diseases associated with hypercholesterolemia.     

定位-运输路线安排问题的一种启发式算法研究

定位-运输路线安排问题（LRP）是分销网络设计和物流管理决策中的难题,属于NP难问题,求解有一定难度.文章通过构造辅助函数对优化问题约束条件的处理,基于分层次实现多个目标的思路将LRP看作一个整体,利用具群体智能的粒子群算法进行求解,避免了基于两阶段算法的不足,减小了在进化过程中停滞于局部最优解的概率.为粒子群算法在大规模组合优化问题中实际应用做了有益的尝试.