Visual Mark for Robot Manipulation and Its RT-Middleware Component

In this paper, a visual marker called Coded Landmark for Ubiquitous Environment (CLUE) is proposed for easy robot manipulation using the RT-middleware component technology. Currently, home service robots are being expected to work in human living environments; however, such environments might be highly complex for robots. One of the solutions to solve such problems might be the development of structured environments for robots, such as visual marks in human living space, which could often be used in industrial fields, e.g., marked lines for mobile robots in industry. For application of structured environments from the factory to the human living environment, the affinity to humans might be important, such as marks invisible to humans, but visible to robots. In this paper, an invisible marker, CLUE, which is based on QR codes, is proposed; this will provide robots with information on the objects that are to be manipulated and visual guidance required for robot manipulation based on the RT-middleware platform. Finally, by means of actual robot applications, the method to use the proposed robot technology component is shown.     

Differential Chemoproteomics Reveals MARK2/3 as Cell Migration-Relevant Targets of the ALK Inhibitor Brigatinib

Metastasis poses a major challenge in cancer management, including EML4-ALK-rearranged non-small cell lung cancer (NSCLC). As cell migration is a critical step during metastasis, we assessed the anti-migratory activities of several clinical ALK inhibitors in NSCLC cells and observed differential anti-migratory capabilities despite similar ALK inhibition, with brigatinib displaying superior anti-migratory effects over other ALK inhibitors. Applying an unbiased in situ mass spectrometry-based chemoproteomics approach, we determined the proteome-wide target profile of brigatinib in EML4-ALK+ NSCLC cells. Dose-dependent and cross-competitive chemoproteomics suggested MARK2 and MARK3 as relevant brigatinib kinase targets. Functional validation showed that combined pharmacological inhibition or genetic modulation of MARK2/3 inhibited cell migration. Consistently, brigatinib treatment induced inhibitory YAP1 phosphorylation downstream of MARK2/3. Collectively, our data suggest that brigatinib exhibits unusual cross-phenotype polypharmacology as, despite similar efficacy for inhibiting EML4-ALK-dependent cell proliferation as other ALK inhibitors, it more effectively prevented migration of NSCLC cells due to co-targeting of MARK2/3.     

S109E联合循环机组一次调频控制策略的研究与实现

简要分析了GE-9E燃气蒸汽联合循环机组转速控制、负荷控制等与一次调频有关的逻辑,介绍了对原9E机组一次调频转速扰动下燃机、汽机负荷的动态响应情况及问题,提出一套在MARK V实现电网要求一次调频功能的控制逻辑。投运及其试验结果表明,采用这套控制逻辑后,9E燃气蒸汽联合循环机组能满足电网的一次调频要求。     

AR物理实验中的磁感线仿真

针对如何在中学物理实验中,在增强现实(AR)的虚拟环境中模拟出符合物理规律的磁感线、电场线等曲线的问题,研究了一套在三维空间中拟合出符合磁感线性质的磁感线算法,并将其应用到多模态自然交互的AR实验系统中.该算法使用四阶龙格库塔方法生成磁感线,并在必要时使用能量最小化的方法进行修正.该AR系统使用基于实物套件的增强现实并...     

LNG围护系统结构失效模式的有限元模拟

LNG运输船设计关键技术之一是液舱围护系统的结构安全设计。为了保证LNG液体的运输安全,需要特别关注围护系统的结构设计,其中对结构失效模式及其发生机理的研究具有很高参考价值。为了能够全面研究薄膜型液舱结构特性,采用基于有限元的数值模拟方法,针对在晃荡荷载下的结构响应,建立了一种简化的二维有限元模型。根据层式复合材料特点,分别选取对应的强度失效准则,分析结构的失效模式。数值分析结果显示,首层聚氨酯泡沫层在晃荡荷载作用下最先发生压溃破坏,在MARKⅢ型液舱设计中应该被重点关注;其他的结构失效模式依次为:次层聚氨酯泡沫层压溃失效、层合板剪切失效以及树脂绳压溃失效。采用数值模拟进行围护系统的截面失效模式分析,能够快速高效地指导LNG液舱结构设计,是在液舱设计领域新的应用尝试。     

燃气透平控制系统的升级改造

从冗余控制、人机接口HMI、控制功能、保护系统、开车许可和停车联锁等方面介绍了燃气透平操作系统MARK VI的技术特点;简述了控制系统由MARKⅣ升级为MARKⅥ的改造过程和调校方法;分析了升级改造后尚待解决的问题;评述了升级改造的运行效果。结果表明,燃气透平控制系统实现了从CRT到HMI电脑操作,全方位提高了机组的自控水平和操作水平。     

MARK VI控制系统故障分析与软件优化

对GE9F级燃汽轮机的MARK VI控制系统投运以来卡件、电源、网络设备等硬件的故障进行了分析,介绍了涉及联锁保护逻辑等的软件优化案例,提出了提高控制系统运行可靠性的几点建议,如定期清灰、软件备份、防病毒等,以供同类型机组运行参考。     

MARK VIe控制系统在西气东输管道上的应用与维护

随着GE燃驱压缩机组在西气东输管道上的相继投产,相配套的MARK VIe燃机控制系统在实际生产中也逐步得到应用,研究该控制系统在实际应用中的使用情况具有一定的意义。通过了解MARK VIe控制系统的构成,根据历史压缩机组控制系统的停机故障统计分布情况及故障处理报告,归纳分析各类故障产生的原因,并列出相应的故障处理措施。认真研究这类问题,总结系统的使用维护经验,有助于提高控制系统的可靠性,保障输气生产的稳定运行。     

德国KHS贴标机的技术特点

KHS贴标机采用伺服电机控制技术,提高贴标精度与速度,色差光眼检测标签MARK点准确控制标签长度,MCU可编程序控制和参数设定功能,促进操作简单化,方便快捷的生产转换程序,是其发挥高效、运行稳定的重要技术手段。     

Multitargeting the Action of 5-HT6 Serotonin Receptor Ligands by Additional Modulation of Kinases in the Search for a New Therapy for Alzheimer’s Disease: Can It Work from a Molecular Point of View?

In view of the unsatisfactory treatment of cognitive disorders, in particular Alzheimer’s disease (AD), the aim of this review was to perform a computer-aided analysis of the state of the art that will help in the search for innovative polypharmacology-based therapeutic approaches to fight against AD. Apart from 20-year unrenewed cholinesterase- or NMDA-based AD therapy, the hope of effectively treating Alzheimer’s disease has been placed on serotonin 5-HT₆ receptor (5-HT₆R), due to its proven, both for agonists and antagonists, beneficial procognitive effects in animal models; however, research into this treatment has so far not been successfully translated to human patients. Recent lines of evidence strongly emphasize the role of kinases, in particular microtubule affinity-regulating kinase 4 (MARK4), Rho-associated coiled-coil-containing protein kinase I/II (ROCKI/II) and cyclin-dependent kinase 5 (CDK5) in the etiology of AD, pointing to the therapeutic potential of their inhibitors not only against the symptoms, but also the causes of this disease. Thus, finding a drug that acts simultaneously on both 5-HT₆R and one of those kinases will provide a potential breakthrough in AD treatment. The pharmacophore- and docking-based comprehensive literature analysis performed herein serves to answer the question of whether the design of these kind of dual agents is possible, and the conclusions turned out to be highly promising.