How Cancer Cells Invade Bladder Epithelium and Form Tumors: The Mouse Bladder Tumor Model as a Model of Tumor Recurrence in Patients

Non-muscle-invasive bladder cancer is the most common form of bladder cancer. The main problem in managing bladder tumors is the high recurrence after the transurethral resection of bladder tumors (TURBT). Our study aimed to examine the fate of intravesically applied cancer cells as the implantation of cancer cells after TURBT is thought to be a cause of tumor recurrence. We established an orthotopic mouse bladder tumor model with MB49-GFP cancer cells and traced them during the first three days to define their location and contacts with normal urothelial cells. Data were obtained by Western blot, immunolabeling, and light and electron microscopy. We showed that within the first two hours, applied cancer cells adhered to the traumatized epithelium by cell projections containing α3β1 integrin on their tips. Cancer cells then migrated through the epithelium and on day 3, they reached the basal lamina or even penetrated it. In established bladder tumors, E-cadherin and desmoplakin 1/2 were shown as feasible immunohistochemical markers of tumor margins based on the immunolabeling of various junctional proteins. Altogether, these results for the first time illustrate cancer cell implantation in vivo mimicking cellular events of tumor recurrence in bladder cancer patients.     

国产MB-86催化剂使用情况分析

抚顺引进的５００００ｔ／ｙ丙烯腈装置要改造到７００００ｔ／ｙ的生产能力，其中更换国产催化剂ＭＢ－８６是较为关键的一步，文章对此进行了总结与分析。     

Advancements in the design and validation of an air pollution integrated assessment model for Spain

This paper describes the design and application of the Atmospheric Evaluation and Research Integrated model for Spain (AERIS). Currently, AERIS can provide concentration profiles of NO₂, O₃, SO₂, NH₃, PM, as a response to emission variations of relevant sectors in Spain. Results are calculated using transfer matrices based on an air quality modelling system (AQMS) composed by the WRF (meteorology), SMOKE (emissions) and CMAQ (atmospheric-chemical processes) models. The AERIS outputs were statistically tested against the conventional AQMS and observations, revealing a good agreement in both cases. At the moment, integrated assessment in AERIS focuses only on the link between emissions and concentrations. The quantification of deposition, impacts (health, ecosystems) and costs will be introduced in the future. In conclusion, the main asset of AERIS is its accuracy in predicting air quality outcomes for different scenarios through a simple yet robust modelling framework, avoiding complex programming and long computing times.     

Hot compression deformation behavior of MB26 magnesium alloy

The flow stress features of MB26 magnesium alloy were studied by isothermal compression at 300-450 ℃ and strain rate of 0.001^-1 s J with Gleeble 1500 thermal simulator. In addition, the deformation activation energy Q was calculated. The results show that the strain rate and deformation temperature have obvious effect on the true stress. The peak value of flow stress becomes larger with increasing strain rate at the same temperature, and gets smaller with the increasing deformation temperature at the same strain rate. The alloy shows partial dynamic recrystallization. The flow stress of MB26 magnesium alloy during high temperature deformation can be represented by Zener-Hollomon parameter including the Arrhemius term. The temperatt, re range of 350-400℃ is suggested for hot-forming of this alloy.     

基于SOA架构的首都机场中间件平台的设计与实现

以首都机场信息系统集成项目为背景,本文主要介绍了基于SOA架构的首都机场中间件平台的设计与实现,以及通过该平台实现的业务标准、数据标准的统一以及硬件平台的整合。     

视频字符叠加器叠加芯片比较

字符叠加（0sD）是一种在视频电子信号中叠加字符信息,使得电视图像中叠加有字符或汉字图形的技术。目前这项技术的应用极其广泛,因此,针对这种需求,结合市场最新技术对实现视频字符叠加进行研究与设计。文章论述了视频字符叠加的原理,并描述了目前市场上流行的叠加芯片的技术指标,就不同的芯片的不同的方案提出分析论证：着重了解MB90092、UPD6453和MAX7456方案的特性与使用方法。     

MB＋网络及其在小峡水电站的应用

小峡水电站现场总线采用MB＋网。介绍了MB＋网的网络结构、特点、组网及通信方式，以及在小峡水电站的应用情况。应用MB+网后，改善了水电站自动化控制系统维护难、故障多、自动化控制水平低等问题；MB+网在实际应用中运行稳定、可靠性高，满足了水电站对设备监视和控制的要求，取得了很好的效果。     

MB2镁合金变形组织性能研究

为了探讨镁合金铸造组织在较低温度下变形时对组织性能的影响,采用现代冶金分析和测试方法,研究了MB2镁合金铸棒在不同变形温度和变形程度下组织演变过程和再结晶行为,并对各变形条件下试样进行拉伸实验.结果表明,通过挤压变形及动态再结晶,可以显著细化铸造MB2合金的晶粒,其尺寸可由铸态的约100 μm减少到5μm;随变形温度的升高,MB2合金的抗拉强度下降,达到一定温度后,趋于稳定;在相同的变形程度下,随着变形温度的升高,晶粒有长大的趋势.