Drug self-assembly: A phenomenon at the nanometer scale with major impact in the structure–biological properties relationship and the treatment of disease

Under water-rich conditions, small amphiphilic and hydrophobic drug molecules self-assemble into supramolecular nanostructures. Thus, substantial modifications in their interaction with cellular structures and the ability to reach intracellular targets could happen. Additionally, drug aggregates could be more toxic than the non-aggregated counterparts, or vice versa. Moreover, since self-aggregation reduces the number of effective “monomeric” molecules that interact with the target, the drug potency could be underestimated. In other cases, the activity could be ascribed to the non-aggregated molecule while it stems from its aggregates. Thus, drug self-assembly could mislead from drug throughput screening assays to advanced preclinical and clinical trials. Finally, aggregates could serve as crystallization nuclei. The impact that this phenomenon has on the biological performance of active compounds, the inconsistent and often controversial nature of the published data and the need for recommendations/guidelines as preamble of more harmonized research protocols to characterize drug self-aggregation were main motivations for this review. First, the key molecular and environmental parameters governing drug self-aggregation, the main drug families for which this phenomenon and the methods used for its characterization are described. Then, promising nanotechnology platforms investigated to prevent/control it towards a more efficient drug development process are briefly discussed.     

基于频谱分析的Procrustes统计步态识别算法

在信息安全越加重要的现代社会,步态识别以其特有的优势作为一种身份识别手段,得到了很多关注.提出一种基于Procrustes均值形状的傅里叶频谱分析(FSAOPMS)的适用于多视角的步态识别方法.利用Procrustes统计形状分析方法将步态序列中人体轮廓的连续步态变化表示成一个紧致的Procrustes均值形状(PMS...     

应用网络化信息管理系统实现设备巡检管理现代化

本文简要叙述了我单位应用设备巡检管理PMS系统的原因及应用效果,证明了根据实际,不断引入先进的管理模式可快速提高企业设备管理现代化水平。     

Co3O4/4A分子筛活化PMS处理高盐AO7废水研究

采用浸渍-焙烧法制备Co₃O₄/4A分子筛复合催化剂,用于活化过一硫酸盐（PMS）处理高盐酸性橙7（AO7）废水。采用扫描电镜、X-射线衍射仪、红外光谱仪等对复合催化剂进行表征,同时考察其稳定性。考察复合催化剂活化PMS对AO7模拟废水的处理效果,结果表明,当Co₃O₄/4A分子筛投加量为0.2 g/L、PMS投加量为0.7 mmol/L、pH为9时,高盐（Na₂SO₄,10 g/L）废水中AO7浓度可在20 min内由15 mg/L左右降至接近0,去除率达99%以上,同时催化剂钴离子溶出量约为0.36 mg/L,低于《地表水环境质量标准》（GB3838-2002）中规定的1 000μg/L。     

地理标志食品安全监管研究

地理标志为WTO-TRIPS协议中七个知识产权形式之一,它以行业团体形式较好地引导企业发展安全、生态,传统的食品,通过控制食品等级质量与数量以确保其品质与信誉,然而,我国地理标志食品业出现一系列食品安全事件,严重破坏了地理标志品牌形象。地理标志食品安全监管研究是以行业监管为主,以企业自律为辅,在地理标志食品安全监管体系的基础上,在生产监管方面,使用良好的生产操作规范与安全控制技术;在品牌管理上,运用CS品牌经营理念;在市场监管方面,推行食品溯源制度,开发PMS平台管理信息系统,以保障自然传统食品特色,把最好、最安全的地理标志食品提供给消费者。     

Utilizing Genomically Targeted Molecular Data to Improve Patient-Specific Outcomes in Autism Spectrum Disorder

Molecular biology combined with genomics can be a powerful tool for developing potential intervention strategies for improving outcomes in children with autism spectrum disorders (ASD). Monogenic etiologies rarely cause autism. Instead, ASD is more frequently due to many polygenic contributing factors interacting with each other, combined with the epigenetic effects of diet, lifestyle, and environment. One limitation of genomics has been identifying ways of responding to each identified gene variant to translate the information to something clinically useful. This paper will illustrate how understanding the function of a gene and the effects of a reported variant on a molecular level can be used to develop actionable and targeted potential interventions for a gene variant or combinations of variants. For illustrative purposes, this communication highlights a specific genomic variant, SHANK3. The steps involved in developing molecularly genomically targeted actionable interventions will be demonstrated. Cases will be shared to support the efficacy of this strategy and to show how clinicians utilized these targeted interventions to improve ASD-related symptoms significantly. The presented approach demonstrates the utility of genomics as a part of clinical decision-making.     

A Case‐Based Reasoning system for complex medical diagnosis

A Case‐Based Reasoning (CBR) system for medical diagnosis mimics the way doctors make a diagnosis. Given a new case, its accuracy in practice depends on successful retrieval of similar cases. CBR systems have had some success in dealing with simple diseases because of the robustness of their case base. However, their diagnostic accuracy suffers when dealing with complex diseases particularly those that involve multiple domains in medicine. An example of such a condition is Premenstrual syndrome (PMS) as it falls under both gynaecology and psychiatry. To address this issue, the paper proposes a CBR‐based expert system that uses the K‐nearest neighbour (KNN) algorithm to search k similar cases based on the Euclidean distance measure. The novelty of the system is in the design of a flexible auto‐set tolerance (T), which serves as a threshold to extract cases for which similarities are greater than the assigned value of T. A prototype software tool with a menu‐driven Graphical User Interface (GUI) has been developed for case input, analysis of results, and case adaptation within the system. Finally, the performance of the tool has been checked on a set of real‐world PMS cases.     

浙江省电力公司配网生产管理系统纵向接入国网PMS

分析了国网生产管理系统（PMS）和浙江省电力公司配网电力生产管理系统（XPMS）功能位置编码规则；深入研究了PMS和XPMS数据表的差异；通过2套系统在设备功能位置、数据表字段等方面的系统对比分析，为浙电XPMS纵向接入国网PMS．实现数据共享提供了理论基础。     

PMS/PZN相对量对PZNT压电陶瓷的影响

采用二次合成法合成了不同PMS/PZN比例的PMS-PZN-PZT系压电陶瓷,并研究了不同的PMS/PZN比例对所研究体系压电陶瓷显微结构和性能的影响。当PMS/PZN等于0.285时,性能最优:机电耦合系数、压电常数、机械品质因数、介电损耗及居里温度分别为0.594、290 pC/N、1 084、0.003 8、350℃,继续对其进行掺杂改性,有望用于制备大功率的压电变压器。     

PMS镜面钢超塑成形强化效应

对ＰＭＳ镜面塑料模具进行恒温超塑成形试验，并对其显微组织结构特点及其强化机制进行研究分析，表明由于超塑变形导致ＰＭＳ钢的细晶强化、位错强化和沉淀强化，使其在超塑精密成形的同时能有效地提高强度。