胸腺五肽辅助治疗肺癌对免疫功能影响及其疗效的系统评价

为了系统地评价胸腺五肽作为辅助药物治疗各种肺癌的疗效及其对机体免疫功能的影响，利用电子检索收集有关胸腺五肽联合放疗或化疗方案治疗肺癌的临床随机对照试验文献，对符合纳入标准的文献，采用RevMan5.3 软件进行系统评价。最终共纳入文献 9 篇，总样本量 784 例。Meta 分析结果表明，胸腺五肽作为辅助药物治疗各种肺癌提高总有效率的差异无统计学意义[OR ＝ 1.44, 95%CI(0.99, 2.10), P ＝0.06 ＞ 0.05]。在对免疫功能的影响方面，胸腺五肽的使用显著增高外周血中的 CD3+ 细胞水平[OR ＝ 5.88, 95% CI(2.34, 9.42), P ＝0.001]，CD4+ 细胞水平也显著上升[OR ＝8.32, 95%CI(5.22, 11.42), P ＜ 0.00001] , CD4＋ /CD8＋比值也有明显的提高[OR ＝ 0.38, 95% CI(0.18, 0.59), P＝0.0002]，但 CD8+ 细胞水平的差异无统计学意义[OR ＝－3.12, 95% CI ( －9.02, 2.79), P ＞0.05]。总的来说，本研究在一定程度上反映了在辅助治疗肺癌方面，胸腺五肽能显著提高外周血中的 CD3+ 细胞水平、CD4+ 细胞水平、CD4+/CD8+ 比值。而对于治疗的有效率、CD8+ 细胞水平，差异无统计学意义。     

Compiler compatible 5.66 Mb/mm2 8T 1R1W register file in 14 nm FinFET technology

1-read/1-write (1R1W) register file (RF) is a popular memory configuration in modern feature rich SoCs requiring significant amount of embedded memory. A memory compiler is constructed using the 8T RF bitcell spanning a range of instances from 32 b to 72 Kb. An 8T low-leakage bitcell of 0.106 μm² is used in a 14 nm FinFET technology with a 70 nm contacted gate pitch for high-density (HD) two-port (TP) RF memory compiler which achieves 5.66 Mb/mm² array density for a 72 Kb array which is the highest reported density in 14 nm FinFET technology. The density improvement is achieved by using techniques such as leaf-cell optimization (eliminating transistors), better architectural planning, top level connectivity through leaf-cell abutment and minimizing the number of unique leaf-cells. These techniques are fully compatible with memory compiler usage over the required span. Leakage power is minimized by using power-switches without degrading the density mentioned above. Self-induced supply voltage collapse technique is applied for write and a four stack static keeper is used for read Vmin improvement. Fabricated test chips using 14 nm process have demonstrated 2.33 GHz performance at 1.1 V/25 °C operation. Overall V_min of 550 mV is achieved with this design at 25 °C. The inbuilt power-switch improves leakage power by 12x in simulation. Approximately 8% die area of a leading 14 nm SoC in commercialization is occupied by these compiled RF instances.     

PLC的大型牵伸卷绕机的应用研究

本文介绍了大型牵伸卷绕机的计算机控制系统，以西门子MMV型变频器为驱动装置，西门子PLC300为控制核心，根据西门子USS协议和MPI协议，实现PLC与变频器、TP27触摸显示屏的通信，取得了较高的控制精度和稳定性，充分满足生产过程的需要，具有广阔的应用前景。     

A new way for constructing high accuracy shock-capturing generalized compact difference schemes

The generalized compact (GC) schemes and some of their important properties are presented. And a new way for constructing high order accuracy and high-resolution GC schemes is presented. The schemes constructed by using this way could satisfy some principles and demands prescribed in advance to ensure some desired properties to the schemes, such as the principle about suppression of the oscillations, the principle of stability, the order of accuracy and number of scheme points, etc. As two examples, a three-point third-order compact scheme and a three-point fifth-order GC scheme satisfying the principle about suppression of the oscillations and the principle of stability are described in this paper. Numerical results show that these schemes are shock-capturing. The time-dependent boundary conditions proposed by Thompson are well employed when the algorithm is applied to the Euler equations of gas dynamics. Fourier analysis shows that the resolution characteristics are spectral-like.     

长25-29井卡钻事故的处理

长２５－２９井在完井阶段通井过程中发生粘附卡钻事故，在处理卡钻过程中又发生卡套铣筒、井漏、溢流等事故及复杂情况。通过对井下情况的认真分析，采取先堵漏后循环再解卡的处理方案，顺利地解除了该次卡钻事故，大大地减少了经济损失。     

Characterization of one-step,chromate-free,primer systems using liquid-state Si and C NMR

Coatings derived from organofunctional silanes have been investigated as possible replacements for the chromate-based systems used in the aerospace industry. In this study, organofunctional silanes [bis-(triethoxysilylpropyl)ethane and bis(triethoxysilylpropyl) tetrasulfide] were reacted with commercially available acrylate (ECO-CRYL™ 9790) and epoxy (EPI-REZ™ WD-510) resins, resulting in a one-step, low-VOC, chromate-free primer. Liquid-state ²⁹Si and ¹³C NMR were used to determine structural characteristics of various optimized formulations.     

Dynamics of novel hydrogen-bonded acidic fluorinated poly(amide-imide-silica) hybrids studied by solid-state NMR

Novel hydrogen-bonded acidic fluorinated poly(amide-imide-silica) hybrid materials, FPAI-SiO₂ (6E and 6F) series, were synthesized by a sol-gel process. The structures and spin relaxation of the hybrids were characterized by infrared (IR), and ²⁹Si and ¹³C nuclear magnetic resonance (NMR) spectroscopy. The abundant Q⁴ structures implied that in free catalyst the degree of condensation of tetramethoxysilane was enhanced by hydrogen-bonded acidic fluorinated poly(amide-imide). The dynamics on the local mobility of the hybrids was investigated by the time constant for energy exchange between ¹H and ²⁹Si spin system (T_SiH) and spin-diffusion path length (L) measurements. It was found that the faster T_SiH of 6E and 6F hybrids compared with the previous study of similar 6C and 6D hybrids implied that 6E and 6F hybrids had more aggregated structures even though the organic terminal segment changed from rigid imide to more flexible amide. The interactions of the charge transfer between donor and acceptor molecules or π-π aromatic stacking may be the dominant factors to affect the structures of 6E and 6F hybrids. Moreover, M¹ and D² segments of 6F hybrids had the same level mobility and the mobility of the 6F hybrids was little improved as the soft and flexible 1,3-bis(3-aminopropyl)-tetramethyl-disiloxane segment was incorporated in the dense structures of 6F hybrids. All of the L values of 6E and 6F hybrids were on the scale of 3.5-4.0 nm. The result also suggested that 6E and 6F hybrids had similar denser structures as 6D hybrids.     

Modified CIELAB formula tested using a textile pass/fail data set

The proposed new color-difference formula of CIE TC 129, which is a modified version of CIELAB, was tested with a recently published data set of textile pass/fail judgments. Goodness of fit is improved, if the parameter of lightness is set near 2, and if, additionally, a weight function for lightness is defined that reduces the weight of a lightness difference with lightness level in relation to chroma or hue scaling. © 1994 John Wiley & Sons, Inc.     

Optimal estimation of parameters of dynamical systems by neural network collocation method

In this paper we propose a new method to estimate parameters of a dynamical system from observation data on the basis of a neural network collocation method. We construct an object function consisting of squared residuals of dynamical model equations at collocation points and squared deviations of the observations from their corresponding computed values. The neural network is then trained by optimizing the object function.The proposed method is demonstrated by performing several numerical experiments for the optimal estimates of parameters for two different nonlinear systems. Firstly, we consider the weakly and highly nonlinear cases of the Lorenz model and apply the method to estimate the optimum values of parameters for the two cases under various conditions. Then we apply it to estimate the parameters of one-dimensional oscillator with nonlinear damping and restoring terms representing the nonlinear ship roll motion under various conditions. Satisfactory results have been obtained for both the problems.     

有机磷灭蚊剂投放浓度和时间对水体总磷的影响

为分析新型低毒有机磷杀虫剂“1%双硫磷颗粒”投放对河道水质的影响,设置不同药剂投放浓度和不同反应时间的室内试验,以TP、NH₃-N及S^2-为目标因子,分析该药剂投放后水体污染物浓度。结果表明:不同试验组水样中S^2-质量浓度均小于0.02 mg/L,NH₃-N质量浓度处于0.029~0.036 mg/L之间,均达到地表水Ⅰ类标准;不同浓度药剂投放1 h后,水体TP质量浓度已达到稳定状态,且在60 h内均保持稳定,药剂投加量与水体TP质量浓度呈显著正相关(R²=0.85);不同处理组的药剂在水体中的TP释放量无明显差异,均在1.06~1.30 mg/g之间。“1%双硫磷颗粒”推荐适宜投放量不会使河道水质恶化到劣Ⅴ类,但增加药剂投放量会增加水体TP污染及富营养化风险。