辐射敏感综合症--AT病研究进展

共济失调性毛细血管扩张综合症(AT)是一种单基因突变引起的遗传性疾病，表现为高辐射敏感性、进行性神经退变、免疫缺陷、早衰及易患癌症等。本文综述了AT病的研究概况，包括AT临床症状、AT基因的定位、结构与功能、辐射对AT细胞信号传导的影响、AT基因组不稳定性及基因治疗。     

The Basic Clinical Applications of Ozone Therapy

Medical ozone is a mixture of ozone and oxygen, prepared via silent electrical discharge, within a concentration range of 0.05 volume % O₃ to max. 5.0 volume % O₃.

In order to exclude its toxic effect on the pulmonary epithelium, the medical ozone/oxygen mixture is administered so that exposure of the respiratory tract is avoided at all times, i.e., without the disturbing effects of its odor.     

Sensory-motor enhancement in a virtual therapeutic environment

The sensory-motor skills of persons with neuromuscular disabilities have been shown to be enhanced by intensive and repetitive therapeutic interventions. This paper describes a form of low immersion virtual reality and a prototype, open source system that allow a user with significant physical disability to actively interact with computer-generated objects whose behaviors promote a game-like interaction. Unlike fully immersive and haptic virtual reality, this approach frees the user from head-mounted displays and gloves. It extracts the user’s real-time silhouette from the output of a remote video camera and uses that two-dimensional outline to interact with graphical objects on screen. In contrast to video games that have been modified with specialized interfaces, this virtual interaction system promotes the repetitive use of goal directed movements of the arms and body, which are essential to promote cortical reorganization, as well as discourage unwanted changes in muscle tissue that result in contracture. A prototype system demonstrates the potential of low immersion technology to motivate users and encourage participation in therapy. It also offers the potential of accommodating the sensory-motor skills of individuals with very significant impairment. The behaviors of the computer-generated graphics can be altered to allow use by those with very limited range of motion and/or motor control. These behaviors can be adjusted to provide a continuing challenge as the user’s skills improve. This prototype is described in terms of functional capabilities that include a silhouette extraction from a video image, and generation of graphical objects that interact with the silhouette. The work is extended with a discussion of a more sophisticated region of interest detection algorithm that can select specific parts of the body.     

1993: Axline's eight principles of play therapy revisited.

Examined V. Axlines's book, Play Therapy (1947) which includes 8 basic principles on non-directive play therapy. Student responses to learning these principles in play therapy classes were also examined. Each student was assigned a play therapy client and was observed and assisted directly by the instructor, a licensed clinical psychologist. Clients were mildly trouble children (aged 5–10 yrs) and were selected from a referral base by the instructor as appropriate for the course. As the semester progressed and students gained direct experience, weekly small (3–4 student) group discussions were held to explore in-depth understanding of play therapy principles and how these principles are put into practice. It is concluded that Axline's book remains a classic text and a foremost resource in the field. Coupling it with experiential learning is an invaluable basis for teaching play therapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

压电驱动微喷雾化器的研制及实验研究

作为一种重要的非注射给药途径，雾化吸入治疗方法具有起效快，药物毒、副作用小等特点，因此被越来越广泛地采用。基于压电驱动喷雾打印机工作基本原理，利用微机加工技术，研制了一种压电驱动微喷雾化器。流量、雾粒的直径和速度是微喷雾化器的重要指标，文中采用相关的仪器分别对这些指标进行了测试。由测试结果可知，微喷雾化器产生的雾粒的直径和速度分布集中，且雾粒直径和速度比较适合于雾化吸入治疗，可能成为一种重要的雾化吸入治疗装置。     

头臂动脉夹层逆行撕裂至主动脉的治疗

目的对头臂分支动脉夹层逆行撕裂至主动脉的罕见病例进行初步探讨。方法近来收治并手术的3例患者,1例为特发性颈动脉夹层,2例为医源性锁骨下动脉夹层,均保守治疗无效而行手术,分别采用腔内治疗和外科旁路手术方法。结果患者术后疼痛明显改善,术后随访复查CTA显示头臂动脉夹层稳定,假腔内血栓形成。结论对于累及主动脉的头臂动脉夹层,腔内治疗和开放手术均为可采用的方法。     

Identification and experimental validation of an HIV model for HAART treated patients

The objective of this paper is to identify the parameters of a human immunodeficiency virus (HIV) evolution model from a clinical data set of patients treated with two different highly active antiretroviral therapy (HAART) protocols. After introducing a model with six state variables, a preliminary step considers the reduction of the number of parameters to be identified by means of sensitivity analysis, and then identifiability items are discussed. A nonlinear optimization-based procedure for identification is developed, which divides the unknown parameters into two families: the group dependent and the patient dependent parameters. Numerical results show that the identified model can be individually adapted to each patient and this result is promising for predicting the effects (e.g., failures or successes) of therapeutic actions.     

Imagery rehearsal therapy: An emerging treatment for posttraumatic nightmares in veterans.

Nightmares are a common complaint among service members exposed to traumatic events, but prevailing paradigms are disposed to a view that nightmares are a secondary phenomenon untreatable with direct therapeutic intervention. Imagery rehearsal therapy is a cognitive-imagery approach with proven efficacy in the treatment of nightmares in civilian trauma victims. Imagery rehearsal therapy not only has potential to reduce nightmare intensity and frequency, but controlled studies show clinically meaningful decreases in all clusters of posttraumatic stress disorder symptoms as well as insomnia. Limited data support its use with combat veterans. Directions for future research with combat veterans are recommended. (PsycINFO Database Record (c) 2010 APA, all rights reserved)