Inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products formation in a bovine serum albumin–fructose model

This study investigated the inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products (fAGEs) formation in a bovine serum albumin (BSA)–fructose model. Model systems of BSA and fructose were prepared, and curcumin or piperine was added. fAGEs and BSA oxidation product (dityrosine, kynurenine and N'-formylkynurenine) contents were determined. The results showed that fAGEs content decreased with increasing concentration of curcumin and piperine (P < 0.05). Addition of curcumin and piperine at 160 µg mL⁻¹ could inhibit fluorescent AGEs by 100% and 93% respectively. Dityrosine and N'-formylkynurenine contents decreased as curcumin and piperine concentration increased (P < 0.05). Furthermore, the result of principal component analysis indicated that curcumin and piperine markedly impeded BSA oxidation, resulting in a lower level of fAGEs in model systems. Therefore, adding curcumin and piperine may facilitate reduced fAGEs levels in BSA–fructose model.     

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

Dietary advanced glycation end products (dAGEs) are complex and heterogeneous compounds derived from nonenzymatic glycation reactions during industrial processing and home cooking. There is mounting evidence showing that dAGEs are closely associated with various chronic diseases, where the absorbed dAGEs fuel the biological AGEs pool to exhibit noxious effects on human health. Currently, due to the uncertain bioavailability and rapid renal clearance of dAGEs, the relationship between dAGEs and biological AGEs remains debatable. In this review, we provide the most updated information on dAGEs including their generation in processed foods, analytical and characterization techniques, metabolic fates, interaction with AGE receptors, implications on human health and reducing strategies. Available evidence demonstrating a relevance between dAGEs and food allergy is also included. AGEs are ubiquitous in foods and their contents largely depend on the reactivity of carbonyl and amino groups, along with surrounding condition mainly pH and heating procedures. Once being digested and absorbed into the circulation, two separate pathways can be involved in the deleterious effects of dAGEs: an AGE receptor‐dependent way to stimulate cell signals, and an AGE receptor‐independent way to dysregulate proteins via forming complexes. Inhibition of AGEs formation during food processing and reduction in the diet are two potent approaches to restrict health‐hazardous dAGEs. To elucidate the biological role of dAGEs toward human health, the following significant perspectives are raised: molecular size and complexity of dAGEs; interactions between unabsorbed dAGEs and gut microbiota; and roles played by concomitant compounds in the heat‐processed foods.     

改性双马来酰亚胺的研究

本文研究了双马来酰亚胺与烯丙基化合物形成的改性树脂体系的固化和热性能，讨论了单体配比、增韧剂、催化剂对性能的影响。     

ARAM·ARIES SPM-Lite便携式遥测地震数据采集系统简介

ARAM·ARIES SPM-Lite便携式遥测地震数据采集系统是加拿大GEO-X公司在2002年下半年推出的全新小型便携式地震数据采集系统。该仪器运用了当今最先进的计算机制造技术、网络化技术和微电子技术,除继承了ARAM-ARIES地震数据采集系统所有功能和技术外,它还简化了硬件结构,使体积更小,重量更轻,功能性更强。更加适应地矿、煤田、丛林和山区进行地震勘探。     

An analog circuit design environment based on cooperating blackboard systems

A novel approach to design automation for analog circuits is presented. The prototype implementation-OASE-has been realized as a set of cooperating expert systems with blackboard architecture. The circuit specific knowledge bases use hybrid representation schemes and are strictly separated from an execution engine containing the necessary control knowledge. This alleviates the knowledge acquisition process as well as the extension and maintenance of existing knowledge. OASE has been developed as a design assistant, featuring different levels of interactivity, a hierarchical design style and fully embedded algorithmic standard tools. In its current version it is able to design a broad range of different CMOS operational amplifiers.     

我国先进制造技术的现状和发展途径

介绍了现在制造业中面临的问题，通过对问题的分析，提出了发展先进制造前沿技术的见解和在我国发展先进制造技术的途径，同时展望了先进制造技术的发展前景。     

我国高等教育伦理道德探析

通过对高等教育伦理道德的探析,解读我国高等教育面临的道德困惑,以适应社会的发展。     

A review on queueing network models with finite capacity queues for software architectures performance prediction

A review is carried out on how queueing network models with blocking have been applied so far into the performance evaluation and prediction of Software Architectures (SA). Queueing network models with finite capacity queues and blocking have recently been introduced and applied as more realistic models of systems with finite capacity resources and population constraints. Queueing network models have been often adopted as models for the evaluation of software performance. Starting from our own experience, we observe the need of a more accurate definition of the performance models of SA to capture some features of the communication systems. We consider queueing networks with finite capacity and blocking after service (BAS) to represent some synchronization constraints that cannot be easily modeled with queueing network models with infinite capacity queues. We investigate the use of queueing networks with blocking as performance models of SA with concurrent components and synchronous communication. Queueing theoretic analysis is used to solve the queueing network model and study the synchronous communication and performance of concurrent software components. Our experience is supported by other approaches that also propose the use of queueing networks with blocking. Directions for future research work in the field are included.