The Effect of Minimally Invasive Hematoma Aspiration on the JNK Signal Transduction Pathway after Experimental Intracerebral Hemorrhage in Rats

Objective: To explore the effect of minimally invasive hematoma aspiration (MIHA) on the c-Jun NH₂-terminal kinase (JNK) signal transduction pathway after intracerebral hemorrhage (ICH). Methods: In this experiment, 300 adult male Wistar rats were randomly and averagely divided into sham-operated group, ICH group and MIHA group. In each group, 60 rats were used in the detection of indexes in this experiment, while the other 40 rats were used to replace rats which reached the exclusion criteria (accidental death or operation failure). In ICH group and MIHA group, ICH was induced by injection of 70 µL of autologous arterial blood into rat brain, while only the rats in MIHA group were treated by MIHA 6 h after ICH. Rats in sham-operated group were injected nothing into brains, and they were not treated either, like rats in ICH group. In each group, six rats were randomly selected to observe their Bederson’s scales persistently (6, 24, 48, 72, 96, 120 h after ICH). According to the time they were sacrificed, the remaining rats in each group were divided into 3 subgroups (24, 72, 120 h). The change of brain water content (BWC) was measured by the wet weight to dry weight ratio method. The morphology of neurons in cortex was observed by the hematoxylin–eosin (HE) staining. The expressions of phospho-c-Jun NH₂-terminal kinase (pJNK) and JNK in peri-hematomal brain tissue were determined by the immunohistochemistry (IHC) and Western blotting (WB). Results: At all time points, compared with the ICH groups, the expression of pJNK decreased obviously in MIHA groups (p < 0.05), while their Bederson’s scales and BWC declined, and neuron injury in the cortex was relieved. The expression level of JNK was not altered at different groups. The data obtained by IHC and WB indicated a high-level of consistency, which provided a certain dependability of the test results. Conclusion: The JNK signal transduction pathway could be activated after intracerebral hemorrhage, with the expressions of pJNK increasing. MIHA could relieve the histo-pathological damage of nerve cells, reducing brain edema and neurological deficits, and these neuroprotective effects might be associated with suppression of JNK signal transduction pathway.     

综掘工作面旋流气幕抽吸控尘流场的数值模拟

针对配有附壁风筒综掘工作面旋流气幕抽吸控尘流场的特点,分别采用k-ε和k-ε-Θ-k_p数学模型建立了该流场单相风流流动和气体-粉尘颗粒两相流动的数学模型,基于同位网格的SIMPLE算法,利用Fluent软件对该流场风流及粉尘的扩散进行了数值模拟。模拟结果显示,综掘工作面旋流气幕抽吸控尘系统可在掘进机司机的前方形成基本封闭整个巷道断面的旋流气幕,能有效地将粉尘封闭在掘进头至掘进机司机前方0.5 m的空间内,防止粉尘向其它区域扩散。依据模拟结果和工作面现场的实际条件,设计了由附壁风筒和抽尘净化装置构成的综掘工作面旋流气幕抽吸控尘系统,该系统在综掘工作面应用后,有效地降低了工作面现场各作业地点的粉尘浓度,取得了较好的降尘效果。     

新型气液分配器在加氢反应器的应用

介绍了几种常见的气液分配器形式及工作原理,包括溢流型分配器、抽吸型分配器和混合型分配器,详细介绍了FRIPP开发的新型气液分配器的主体结构和工作原理,该分配器在某公司加氢反应器进行了工业应用,运行结果表明,床层温度分布均匀,同一床层各测温点温差≤1℃,显示了其优异的性能,具有广阔的市场前景。     

应用误吸风险评估及饮食分级护理预防听神经瘤术后误吸

目的：探讨饮食分级护理和预防听神经瘤术后患者进食误吸的护理效果。方法将100例听神经瘤术后患者按入院时间排序分为干预组（2015年7~12月,50例）和对照组（2015年1~6月,50例）。对照组按照常规护理,干预组术后采用吞误吸风险等级划分,并在此基础上根据误吸风险等级实施饮食分级护理。比较两组患者干预期间进食时误吸发生情况。结果在干预前,两组术后误吸风险比较,差异无统计学意义（P﹥0.05）。干预后,对照组共发生误吸20次,误吸发生率为5.60％,其中呛咳18次,噎食3次,窒息1次;干预组共发生误吸8次,误吸发生率为0.94％,其中呛咳5次,噎食2次,无窒息发生。两组误吸发生率比较差异有统计学意义（ P＜0.01）。结论对听神经瘤术后患者行误吸风险分级,并实施相应的饮食分级护理措施,可有效降低误吸风险,。     

一种求解旅行商问题的禁忌搜索算法

提出了一种求解旅行商问题的禁忌搜索算法，并对几个实例进行了计算机模拟．实验结果表明，在求解中小规模的旅行商问题上，该算法具有良好的性能．     

Fast and selective cell isolation from blood sample by microfiber fabric system with vacuum aspiration

Since circulating tumor cells (CTCs) are tumor cells which are found in the blood of cancer patients, CTCs are potential tumor markers, so a rapid isolation of CTCs is desirable for clinical applications. In this paper, a three-dimensional polystyrene (PS) microfiber fabric with vacuum aspiration system was developed for capturing CTCs within a short time. Various microfiber fabrics with different diameters were prepared by the electrospinning method and optimized for contact frequency with cells. Vacuum aspiration utilizing these microfiber fabrics could filter all cells within seconds without mechanical damage. The microfiber fabric with immobilized anti-EpCAM antibodies was able to specifically capture MCF-7 cells that express EpCAM on their surfaces. The specificity of the system was confirmed by monitoring the ability to isolate MCF-7 cells from a mixture containing CCRF-CEM cells that do not express EpCAM. Furthermore, the selective capture ability of the microfiber was retained even when the microfiber was exposed to the whole blood of pigs spiked with MCF-7 cells. The specific cell capture ratio of the vacuum aspiration system utilizing microfiber fabric could be improved by increasing the thickness of the microfiber fabric through electrospinning time.     

谈科技工作者成长之路——在全国水利行业高层次专业技术人才研讨班上的报告

当前我国水利水电建设的规模是史无前例的,这就为我国广大水利科技工作者提供了一个千载难逢的建功立业的机遇,但能否把握住这个机遇,干出一番事业,还取决于本人的主观努力:干一番事业的意志,坚实的专业基础,勤于工作,勤于学习,勤于思考,联系实际,勇于创新,艰苦奋斗,自强不息。     

Three determinants of the level of aspiration.

"In a design similar to that of Chapman and Volkmann, the effect of reference group was again found to be a significant anchoring point for S's aspiration level. The effects of 2 other dimensions of the design, sample question difficulty and reference score, have also been found to have significant anchoring influences which explain the puzzling portion of Chapman and Volkmann's results. In that phase of this study in which the 3 reference groups were coupled with high reference scores, Ss' aspiration-levels were below that of any prediction based on the anchoring effect of the reference group alone." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fear of failure and unrealistic vocational aspiration.

Realistic or unrealistic vocational aspiration was related to need for achievement and assessment of one's capability. The person more strongly motivated to avoid failure, rather than to achieve success, tended to be unrealistic in his vocational aspiration (under or over) rather than to aspire towards some realistic goal wherein he might actually have to prove himself. (PsycINFO Database Record (c) 2010 APA, all rights reserved)