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1.
目的: 建立快速灵敏的LC-MS/MS法测定人血浆中阿莫西林浓度,并用于两种阿莫西林胶囊的一致性评价。方法: 采用岛津公司LCMS-8060型LC-MS/MS仪,以MRM模式测定阿莫西林(m/z 366.00/114.00)的浓度,d4-阿莫西林作内标(m/z 370.10/114.05),离子源为ESI源。色谱柱选用Waters ACQUITY BEH C18(2.1×50 mm,1.7 μm),梯度洗脱。血浆样本加入内标,经甲醇沉淀蛋白后取上清液进样检测。结果: 所建方法经验证,其线性、准确度、精密度、最低定量限、提取回收率、特异性、基质效应、稳定性等各项指标均符合CFDA的指导原则及最新核查标准要求,并较文献报道中的方法有处理简单、灵敏度高、色谱峰形好的优点。结论: 所建方法快速、灵敏,适用于人血浆中阿莫西林浓度的检测。用于一致性评价的样本实测,两种制剂生物等效。  相似文献   
2.
Filtering algorithms are well accepted as a means of speeding up the solution of the consistent labeling problem (CLP). Despite the fact that path consistency does a better job of filtering than arc consistency, AC is still the preferred technique because it has a much lower time complexity. We are implementing parallel path consistency algorithms on multiprocessors and comparing their performance to the best sequential and parallel arc consistency algorithms.(1,2) (See also work by Kerethoet al. (3) and Kasif(4)) Preliminary work has shown linear performance increases for parallelized path consistency and also shown that in many cases performance is significantly better than the theoretical worst case. These two results lead us to believe that parallel path consistency may be a superior filtering technique. Finally, we have implemented path consistency as an outer product computation and have obtained good results (e.g., linear speedup on a 64K-node Connection Machine 2).  相似文献   
3.
结合兰州市的水泥标准稠度用水量方法测定 (代用法 )的实例 ,分析代用法测定标准稠度用水量的缺点 ,并对此方法提出了一些改进措施  相似文献   
4.
We propose a general modeling framework to evaluate the performance of cache consistency algorithms. In addition to the usual hit rate, we introduce the hit* rate as a consistency measure, which captures the fraction of non-stale downloads from the cache. We apply these ideas to the analysis of the fixed TTL consistency algorithm in the presence of network delays. The hit and hit* rates are evaluated when requests and updates are modeled by renewal processes. Classical results on the renewal function lead to various bounds.  相似文献   
5.
Abstract. The estimation of the spectral density function of a stationary Gaussian process at the input of an instantaneous nonlinearity is considered when the nonlinearity is known and a finite set of observations of the output process is given. A class of spectral estimates is considered and their quadratic-mean consistency is established; precise asymptotic expressions for their bias and covariance are derived and their asymptotic normality is obtained.  相似文献   
6.
保序回归的大样本性质   总被引:1,自引:0,他引:1  
利用保序回归与极大似然估计之间的关系,从极大似然估计解的大样本性质出发,得到了保序回归解的两个大样本性质。  相似文献   
7.
Repeated reference creates strong expectations in addressees that a speaker will continue to use the same expression for the same object. The authors investigate the root reason for these expectations by comparing a cooperativeness-based account (Grice, 1975) with a simpler consistency-based account. In two eye-tracking experiments, the authors investigated the expectations underlying the effect of precedents on comprehension. The authors show that listeners expect speakers to be consistent in their use of expressions even when these expectations cannot be motivated by the assumption of cooperativeness. The authors conclude that though this phenomenon seems to be motivated by cooperativeness, listeners' expectation that speakers be consistent in their use of expressions is governed by a general expectation of consistency. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
8.
解决注水泥作业的防气窜问题,是提高固井质量,保护油气层的关键技术。现有预测和防止水泥浆气管理的方法虽然较多,但应用于现场却有一定困难,主要表现在所考虑的因素比较单一,有些高温、高压下的水泥浆性能参数难以测定。文章在分析国内外预测和防止气窜方法的基础上,应用水泥浆浆体在环空的组成,GFP系数、水泥浆稠度阻力系数(A)及多凝水泥和环空加压等措施,拟定出一套提高水泥浆顶替效率,保证水泥浆动态和静态过程压力平衡关系的具体设计方法。  相似文献   
9.
论校园文化和德育目标的一致性   总被引:3,自引:0,他引:3  
中系统介绍了校园化和德育目标的关系,并找准两之间的结合点,通过分析两的一致性和辩证统一关系,达到育人目的。  相似文献   
10.
Examination of the assumptions underlying consistency perspectives in social and personality psychology reveals that they are based on an independent, individualistic view of the self. If the self is constructed as relational or interdependent with others, consistency may be less important in social behavior and well-being. Using a variety of measures of well-being, the studies showed that there is a weaker relation between consistency and well-being for individuals with a highly relational self-construal than for those with a low relational self-construal. Study 3 examined the association between the self-construal, consistency, authenticity, and well-being. These findings reveal the importance of a cultural analysis of theories of the self, personality, and well-being for further theory development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
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