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1.
《Ceramics International》2022,48(20):29892-29899
It is very challenging for 3D printing based on the selective laser melting (SLM) technology to obtain cermet bulk materials with high density and homogeneous microstructures. In this work, the SLM process of the cermet powders was studied by both simulations and experiments using the WC-Co cemented carbides as an example. The results indicated that the evolution of the ceramic and metallic phases in the cermet particle during the heating, melting and solidification processes were all significantly inhomogeneous from atomic scale to mesoscale microstructures. As a consequence, the microstructural defects were caused intrinsically in the printed bulk material. The formation and growth of the bonding necks between the particles were mainly completed at the later stage of laser heating and the early stage of solidification. Both simulations and experiments demonstrated that thin amorphous layers formed at the ceramics/metal interfaces. This work disclosed the mechanisms for the evolution from the atomic scale to microstructure during the SLM printing of cermet powders, and discovered the origin of the defects in the printed cermet bulk materials. 相似文献
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The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis. Importantly, COX-2 is activated in response to inflammatory stimuli, where it is also believed to promote the development and progression of head and neck cancers (HNC). COX-2 can mediate its protumorigenic effect through various mechanisms, such as inducing cell proliferation, inhibition of apoptosis, and suppressing the host’s immune response. Furthermore, COX-2 can induce the production of vascular endothelial growth factors, hence, promoting angiogenesis. Indeed, the ability of COX-2 inhibitors to selectively restrict the proliferation of tumor cells and mediating apoptosis provides promising therapeutic targets for cancer patients. Thus, in this comprehensive review, we summarized the reported differential expression patterns of COX-2 in different stages of head and neck carcinogenesis—from potentially premalignant lesions to invasive carcinomas. Furthermore, we examined the available meta-analysis evidence for COX-2 role in the carcinogenesis of HNC. Finally, further understanding of the biological processes of COX-2 and its role in orchestrating cell proliferation, apoptosis, and angiogenesis may give therapeutically beneficial insight to develop the management plan of HNC patients and improve their clinical outcomes. 相似文献
3.
啤酒标签用铝箔力学性能研究 总被引:3,自引:2,他引:1
分析研究了连续铸轧坯料的合金成分,冶金组织和热处理工艺对啤酒标用铝箔力学性能的影响,选定成形性优良的合金系列,并优化铸轧工艺和热处理工艺是提高铝箔力学性能的关键。 相似文献
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瓶级聚酯切片中乙醛含量的控制 总被引:1,自引:0,他引:1
对瓶级聚对苯二甲酸乙二酯(PET)原料中的乙醛含量、第三组份(间苯二甲酸)含量、原料比表面积以及工艺参数控制等对产品中乙醛含量的影响进行了讨论,得出了合适的工艺操作条件,并注意到预结晶单元和冷却单元的工艺参数控制对产品乙醛含量的影响最显著,从而为生产乙醛含量小于1.0μg/g的瓶级高粘度PET切片提供了参考。 相似文献
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Barbora Peltanova Marketa Liskova Jaromir Gumulec Martina Raudenska Hana Holcova Polanska Tomas Vaculovic David Kalfert Marek Grega Jan Plzak Jan Betka Michal Masarik 《International journal of molecular sciences》2021,22(4)
Cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components of the tumor stroma. CAFs can impact many important steps of cancerogenesis and may also influence treatment resistance. Some of these effects need the direct contact of CAFs and cancer cells, while some involve paracrine signals. In this study, we investigated the ability of head and neck squamous cell carcinomas (HNSCC) patient-derived CAFs to promote or inhibit the colony-forming ability of HNSCC cells. The effect of cisplatin on this promoting or inhibiting influence was also studied. The subsequent analysis focused on changes in the expression of genes associated with cancer progression. We found that cisplatin response in model HNSCC cancer cells was modified by coculture with CAFs, was CAF-specific, and different patient-derived CAFs had a different “sensitizing ratio”. Increased expression of VEGFA, PGE2S, COX2, EGFR, and NANOG in cancer cells was characteristic for the increase of resistance. On the other hand, CCL2 expression was associated with sensitizing effect. Significantly higher amounts of cisplatin were found in CAFs derived from patients who subsequently experienced a recurrence. In conclusion, our results showed that CAFs could promote and/or inhibit colony-forming capability and cisplatin resistance in HNSCC cells via paracrine effects and subsequent changes in gene expression of cancer-associated genes in cancer cells. 相似文献
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介绍了国内外废旧PET瓶通过物理或化学回收方法制取再生薄片、粒料、纤维、片材、泡沫塑料、复合材料、涂料等的应用进展;另外,对于闭环循环的PET“瓶-瓶”回收工艺技术进行了专门介绍。 相似文献
10.
利用材料的生命周期评估法对聚酯瓶的生态性能和设计要点进行分析。瓶级聚酯的巨大市场 ,优良的物理化学性能 ,简便安全的加工使用特点 ,使聚酯瓶成为一次包装革命。其可持续发展的关键是回收利用。目前回收最多的国家为 3 4% ,60 %以上回收物用于生产纤维。应针对各种回收方法 ,建立稳定的消费 回收 再循环加工的网络。 相似文献