Epigenetic Targets for Oligonucleotide Therapies of Pulmonary Arterial Hypertension

Arterial wall remodeling underlies increased pulmonary vascular resistance and right heart failure in pulmonary arterial hypertension (PAH). None of the established vasodilator drug therapies for PAH prevents or reverse established arterial wall thickening, stiffening, and hypercontractility. Therefore, new approaches are needed to achieve long-acting prevention and reversal of occlusive pulmonary vascular remodeling. Several promising new drug classes are emerging from a better understanding of pulmonary vascular gene expression programs. In this review, potential epigenetic targets for small molecules and oligonucleotides will be described. Most are in preclinical studies aimed at modifying the growth of vascular wall cells in vitro or normalizing vascular remodeling in PAH animal models. Initial success with lung-directed delivery of oligonucleotides targeting microRNAs suggests other epigenetic mechanisms might also be suitable drug targets. Those targets include DNA methylation, proteins of the chromatin remodeling machinery, and long noncoding RNAs, all of which act as epigenetic regulators of vascular wall structure and function. The progress in testing small molecules and oligonucleotide-based drugs in PAH models is summarized.     

Sanitary legislation governing Food Services in Brazil

The Technical Regulation of Good Practices for Brazilian Food Services (Regulamento Técnico de Boas Práticas para Serviços de Alimentação do Brasil) can be complemented by sanitary surveillance agencies at the state, district and municipal levels by tailoring it to location-specific requirements. The purpose of the present study was to survey sanitary legislation governing Brazilian Food Services. During the period from November 2011 to November 2012, a survey was conducted with the sanitary surveillance agencies from the various states, capitals and the Federal District. A previously prepared and tested tool was used for data collection, comprising 10 questions. Only 10 (19.2%) of the sanitary codes had been established prior to RDC Resolution n° 216/2004 and were not complementary. Of the legislation cited as complementary, only the states of Santa Catarina, Rio Grande do Sul and São Paulo and the capital of the state of São Paulo truly presented additional and location-specific aspects. No legislation that was specific to hospital kitchens was found. The majority of participating coordination, including the Evaluation List for Good Practices in Food Services, was also verified; however, it had not been published. In conclusion, a gap in sanitary surveillance services exists, which was caused by the lack of location-specific food service regulations.     

基于ASP.NET技术的新闻发布系统的设计与实现

完整描述了一种在部队师旅级单位通用的新闻发布系统。首先根据用户的特点,对系统进行了需求分析与功能模块划分,然后在此基础上从系统架构、系统流程和数据库设计等3个方面阐述了系统设计中的关键点,并以设计用户登录界面为例写出了部分功能的实现程序,最后对其在中小型企业建站中的应用进行了展望。     

低重分配概率的OVSF码重分配算法

在采用正交可变长扩频因子(OVSF)码作为信道化码的直接序列扩频码分多址系统中,提出用重分配概率作为重分配算法的一个新的评价指标,重分配概率越小,系统的计算复杂度越低。进而提出一种低重分配概率的、基于空码容量的重分配算法,在解决本次码阻塞的同时,兼顾对未来高数据速率的呼叫的支持能力,减少未来码阻塞发生。仿真证实,重分配概率比已有2种重分配算法都小。     

（2m，2，m）非线性等重码不是最佳检错码

本文证明了当ｍ＞４时（２ｍ，２，ｍ）非线性等重码不是最佳检错码。     

适用于快速平台测井的多通道核能谱测井仪设计

介绍一种基于快速平台测井要求的多通道核能谱测井仪设计方案。复杂可编程逻辑器件的应用使仪器功能增强，规模减小。该系统可对岩性密度长短源距脉冲信号、自然γ能谱脉冲信号进行多道脉冲幅度分析，并对补偿中子测井信号及井下多路常规模拟信号、脉冲信号进行数字化采集。数据传输采用曼彻斯特编码，传输方式可选择20kB／s半双工(兼容Atlas 3508)或下行20kB／s、上行41．66或93．75kB／s全双工方式(兼容Atlas WTS)，适应挂接到不同测井系统的需要。     

现行规范对“锁住区”起点高度简化处理的影响

通过工程实例及理论分析 ,对横向风振“锁住区”问题进行了探讨 ,对《建筑结构荷载规范》(GB5 0 0 0 9— 2 0 0 1 )中有关这一方面内容存在的一些问题进行了分析 ,希望对工程设计人员能有所帮助     

基于滑窗结构的软输出维特比算法的实现

文章在对软输出维特比算法(SOVA)进行推导的基础上，分析了软信息的提取过程。同时从硬件实现的角度考虑，提出了一种基于滑动窗1：3结构的SOVA算法实现方案，该算法大大降低了算法实现复杂度和译码延迟，同时通过调整滑窗参数，可以取得与非滑窗SOVA算法几乎相同的性能。     

On regular drawn symbolic picture languages

Drawn symbolic pictures are an extension of drawn pictures obtained by associating a symbol from an alphabet to each point of the picture. In the paper we will address some new interesting issues derived from the introduction of the symbols and we will identify the conditions, which ensure the preservation of properties holding for drawn pictures in the setting of the proposed extension.     

1/3码的动态CMOS全自检电路的设计

自检测电路设计方法有多种多样,本文中介绍了TSC电路的概念,并采用1/3码的动态CMOS设计TSC电路,通过在Cadence环境下仿真,仿真结果表明本设计可行。