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1.
D.R. Santos‐Peñate C.M. Campos‐Rodríguez J.A. Moreno‐Pérez 《International Transactions in Operational Research》2019,26(1):340-363
The ‐centroid problem or leader–follower problem is generalized considering different customer choice rules where a customer may use facilities belonging to different firms, if the difference in travel distance (or time) is small enough. Assuming essential goods, some particular customer choice rules are analyzed. Linear programming formulations for the generalized ‐medianoid and ‐centroid problems are presented and an exact solution approach is applied. Some computational examples are included. 相似文献
2.
Dr. Maria L. Di Paolo Dr. Michael S. Christodoulou Dr. Alessandra M. Calogero Dr. Luca Pinzi Prof. Giulio Rastelli Prof. Daniele Passarella Prof. Graziella Cappelletti Prof. Lisa Dalla Via 《ChemMedChem》2019,14(18):1641-1652
A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (Ki) values in the sub-micromolar range and a good selectivity index (Ki MAO-A/Ki MAO-B>50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4 a ) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity. 相似文献
3.
制造业企业竞争情报系统建设浅析 总被引:1,自引:0,他引:1
讨论了制造业企业信息化进程中包含竞争情报系统的必要性。论述了该类企业竞争情报系统的内涵及功能特征。较详细地介绍了相应系统常用外部数据资源内容及各自应用特点;此外本文还简要地说明了该类系统现有开发支持工具软件、开发关键步骤等内容。 相似文献
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为了准确、快速地进行缺陷识别,介绍了一种新型的前馈神经网络模型,即径向基概率神经网络。与以往的算法相比,该方法具有分类识别精度高且速度快的优点。仿真获得了很好的结果。 相似文献
6.
This study investigates the relationship between the critical surface tension of wetting of celestite and agglomeration recovery as well as the zeta potential in dependence of pH and amount of collector (Na‐Oleate). For this purpose, effects of pH and collector amount on the agglomeration recovery are investigated and zeta potential measurements and Fourier Transform Infrared Spectrophotometer (FTIR) analyses are carried out to determine the adsorption type of Na‐Oleate on celestite surface. The sessile drop technique is used for the measurement of contact angle and determination of the critical surface tension of wetting (YC) of celestite. The maximum agglomeration recovery is obtained at pH 7. The critical surface tension of wetting of celestite is very close to the surface tension of kerosene, which is 25.95 mN/m. Furthermore, at the optimum Na‐Oleate amount of 10 kg/ton, the critical surface tension of wetting of celestite is approximately equal to the surface tension of kerosene. 相似文献
7.
Vibro-fluidized beds are widely used in drying sticky powders and agglomerated materials as milk powder. Using a vibro-fluidized laboratory scale dryer, this work is aiming at analyzing preliminarily the effect of its operational variables on the drying kinetics and characteristics of whole milk powder. The full-factorial design technique with three replications at the central point has been employed to generate data and correlations to quantify the effect of inlet air temperature, air flow rate, and vibration bed amplitude on the drying curves and the milk powder properties related to its faster reconstitution in water (as tapped density, Hausner cohesion ratio, agglomerate size distribution, and internal pore concentration). Results obtained are analyzed and discussed to identify the adequate operation condition for final drying whole milk powder in vibro-fluidized beds, assuring a high product quality. 相似文献
8.
文章从提高铜加工产业国际竞争力角度,比较宏观地分析了浙江省铜加工产业国际竞争力提高的环境、积极与消极因素,针对性地提出了提升浙江省铜加工产业国际竞争力的应对思路。 相似文献
9.
研究了产品开发及快速实现过程中任务获取、任务分配、进度的协调、信息传输等相关问题,并以某半导体产品为例,进行了产品的设计和快速实现,为缩短产品开发和上市周期、提高产品的市场竞争力积累经验。 相似文献
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