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1.
Gotlib Ian H.; Krasnoperova Elena; Yue Dana Neubauer; Joormann Jutta 《Canadian Metallurgical Quarterly》2004,113(1):127
An information-processing paradigm was used to examine attentional biases in clinically depressed participants, participants with generalized anxiety disorder (GAD), and nonpsychiatric control participants for faces expressing sadness, anger, and happiness. Faces were presented for 1,000 ms, at which point depressed participants had directed their attention selectively to depression-relevant (i.e., sad) faces. This attentional bias was specific to the emotion of sadness; the depressed participants did not exhibit attentional biases to the angry or happy faces. This bias was also specific to depression; at 1,000 ms, participants with GAD were not attending selectively to sad, happy, or anxiety-relevant (i.e., angry) faces. Implications of these findings for both the cognitive and the interpersonal functioning of depressed individuals are discussed and directions for future research are advanced. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
2.
Three-dimensional models, or pharmacophores, describing Euclidean constraints on the location on small molecules of functional
groups (like hydrophobic groups, hydrogen acceptors and donors, etc.), are often used in drug design to describe the medicinal
activity of potential drugs (or ‘ligands’). This medicinal activity is produced by interaction of the functional groups on
the ligand with a binding site on a target protein. In identifying structure-activity relations of this kind there are three
principal issues: (1) It is often difficult to “align” the ligands in order to identify common structural properties that
may be responsible for activity; (2) Ligands in solution can adopt different shapes (or `conformations’) arising from torsional
rotations about bonds. The 3-D molecular substructure is typically sought on one or more low-energy conformers; and (3) Pharmacophore
models must, ideally, predict medicinal activity on some quantitative scale. It has been shown that the logical representation
adopted by Inductive Logic Programming (ILP) naturally resolves many of the difficulties associated with the alignment and
multi-conformation issues. However, the predictions of models constructed by ILP have hitherto only been nominal, predicting
medicinal activity to be present or absent. In this paper, we investigate the construction of two kinds of quantitative pharmacophoric
models with ILP: (a) Models that predict the probability that a ligand is “active”; and (b) Models that predict the actual
medicinal activity of a ligand. Quantitative predictions are obtained by the utilising the following statistical procedures
as background knowledge: logistic regression and naive Bayes, for probability prediction; linear and kernel regression, for
activity prediction. The multi-conformation issue and, more generally, the relational representation used by ILP results in
some special difficulties in the use of any statistical procedure. We present the principal issues and some solutions. Specifically,
using data on the inhibition of the protease Thermolysin, we demonstrate that it is possible for an ILP program to construct
good quantitative structure-activity models. We also comment on the relationship of this work to other recent developments
in statistical relational learning.
Editors: Tamás Horváth and Akihiro Yamamoto 相似文献
3.
This article proposes a model of the ways in which dyadic interactions between employees who occupy 1 of 4 archetypal social roles in organizations can lead to either episodic or institutionalized patterns of victimization. The model shows how the occurrence of victimization involving these 4 role types is influenced by organizational variables such as power differences, culture, and access to social capital. The model integrates behavioral and social structural antecedents of victimization to develop a relational perspective on the dynamics of harmful behavior in the workplace. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
The aditi deductive database system 总被引:2,自引:0,他引:2
Jayen Vaghanl BSc Kotagiri Ramamohanarao Ph.D. David B. Kemp Ph.D. Zoltan Somogyi Ph.D. Peter J. Stuckey Ph.D. Tim S. Leask BSc James Harland Ph.D. 《The VLDB Journal The International Journal on Very Large Data Bases》1994,3(2):245-288
Deductive databases generalize relational databases by providing support for recursive views and non-atomic data. Aditi is a deductive system based on the client-server model; it is inherently multi-user and capable of exploiting parallelism on shared-memory multiprocessors. The back-end uses relational technology for efficiency in the management of disk-based data and uses optimization algorithms especially developed for the bottom-up evaluation of logical queries involving recursion. The front-end interacts with the user in a logical language that has more expressive power than relational query languages. We present the structure of Aditi, discuss its components in some detail, and present performance figures. 相似文献
5.
Stolorow Robert D.; Atwood George E.; Orange Donna M. 《Canadian Metallurgical Quarterly》2006,23(1):184
In omitting crucial words and sentencees, neglecting relevant citations, and overlooking important distinctions, Jon Mills' (see record 2005-04819-001) critique of relational psychoanalysis significantly misrepresents the authors' viewpoint. This viewpoint seeks to contextualize, but not to nullify, individual worlds of experience and their limiting horizons. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Cezar Câmpeanu 《Information Processing Letters》2004,92(6):267-274
We define the pattern expressions as an extension of both regular expressions and patterns. We prove several properties of the new family of languages, similar to those of extended regex languages [Câmpeanu et al., Int. J. Found. Comput. Sci. 14 (6) (2003) 1007-1018]. We also define an automata system that recognizes these languages. Differences between regex and pattern expressions are also discussed. 相似文献
7.
The paper describes a prototype system called HiSQL (Historical SQL) which extends the functionality of SQL in manipulating
historical data, by providing functions for spatial and temporal processing. Conceptually the paper is divided into three
parts: the first part deals with the design and architecture of the system; the second part introduces a case study (the defters);
and the third part describes specific functions for spatial and temporal processing of serial documents. The paper concludes
with a comparison between HiSQL and SQL and suggestions for further work.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
8.
SQL语言中量词和空值的使用技术 总被引:1,自引:0,他引:1
丁宝康 《计算机研究与发展》1994,31(3):15-22
在SQL语言中可以引入全称量词符号FORALL,使SQL语言使用更为自然,方便。本文讨论全称量词,存在量词和ALL三种谓词之间的转换,联系和区别,以及空值存在时SQL的使用技术。 相似文献
9.
U. Reimer
H. -J. Schek
《Data & Knowledge Engineering》1989,4(4):321-352The first part of this paper introduces the basic constructs of a frame representation model and gives a formal definition for them. Subsequently the nested relational model (NF2) is described as an extension of the classical relational model to support relation-valued attributes. In the second part of this paper both models are compared with each other and a mapping of frame representation structures to NF2 structures is specified. The structural similarities between frames and NF2 relations are made clear and it is shown that their main difference is due to the type polymorphism introduced by the concept hierarchy of the frame model. This causes type collisions to occur in the strictly typed NF2 model when frames are directly mapped to NF2 structures. Two solutions to this problem are suggested and compared. The paper concludes with a reformulation of query operations of the frame model in terms of NF2 algebra operations. 相似文献
10.
We describe a formal language/notation for DNA molecules that may contain nicks and gaps. The elements of the language, DNA
expressions, denote formal DNA molecules. Different DNA expressions may denote the same formal DNA molecule. We analyse the
shortest DNA expressions denoting a given formal DNA molecule. We determine lower bounds on their lengths and explain how
we construct these minimal DNA expressions. 相似文献