The Function of Sialidase Revealed by Sialidase Activity Imaging Probe

Sialidase cleaves sialic acid residues from glycans such as glycoproteins and glycolipids. In the brain, desorption of the sialic acid by sialidase is essential for synaptic plasticity, learning and memory and synaptic transmission. BTP3-Neu5Ac has been developed for sensitive imaging of sialidase enzyme activity in mammalian tissues. Sialidase activity in the rat hippocampus detected with BTP3-Neu5Ac increases rapidly by neuronal depolarization. It is presumed that an increased sialidase activity in conjunction with neural excitation is involved in the formation of the neural circuit for memory. Since sialidase inhibits the exocytosis of the excitatory neurotransmitter glutamate, the increased sialidase activity by neural excitation might play a role in the negative feedback mechanism against the glutamate release. Mammalian tissues other than the brain have also been stained with BTP3-Neu5Ac. On the basis of information on the sialidase activity imaging in the pancreas, it was found that sialidase inhibitor can be used as an anti-diabetic drug that can avoid hypoglycemia, a serious side effect of insulin secretagogues. In this review, we discuss the role of sialidase in the brain as well as in the pancreas and skin, as revealed by using a sialidase activity imaging probe. We also present the detection of influenza virus with BTP3-Neu5Ac and modification of BTP3-Neu5Ac.     

Nacre-Inspired,Liquid Metal-Based Ultrasensitive Electronic Skin by Spatially Regulated Cracking Strategy

The realization of liquid metal-based wearable systems will be a milestone toward high-performance, integrated electronic skin. However, despite the revolutionary progress achieved in many other components of electronic skin, liquid metal-based flexible sensors still suffer from poor sensitivity due to the insufficient resistance change of liquid metal to deformation. Herein, a nacre-inspired architecture composed of a biphasic pattern (liquid metal with Cr/Cu underlayer) as “bricks” and strain-sensitive Ag film as “mortar” is developed, which breaks the long-standing sensitivity bottleneck of liquid metal-based electronic skin. With 2 orders of magnitude of sensitivity amplification while maintaining wide (>85%) working range, for the first time, liquid metal-based strain sensors rival the state-of-art counterparts. This liquid metal composite features spatially regulated cracking behavior. On the one hand, hard Cr cells locally modulate the strain distribution, which avoids premature cut-through cracks and prolongs the defect propagation in the adjacent Ag film. On the other hand, the separated liquid metal cells prevent unfavorable continuous liquid-metal paths and create crack-free regions during strain. Demonstrated in diverse scenarios, the proposed design concept may spark more applications of ultrasensitive liquid metal-based electronic skins, and reveals a pathway for sensor development via crack engineering.     

三重介质油藏干扰试井压力动态特征

在建立三重介质油藏试井解释模型的基础上，对该类油藏的干扰试井压力动态变化进行了研究；分析了井筒储存、表皮系数、窜流系数以及弹性储容比对观测井井底压力的影响。结果表明，表皮系数对观测井的井底压力没有影响，而井筒储存是否会对观测井井底压力造成影响取决于井筒储存系数的大小以及激动井和观测井之间的距离，窜流系数和弹性储容比对观测井井底压力的影响与单井试井的结果相类似。     

FF现场总线的网段负载能力的设计及计算

从生产安全运行的管理要求；电压压降和电流的限制及信号的衰减；网络运行时间的要求；系统设计的影响；备用能力的考虑等各个方面，结合上海赛科聚苯乙烯项目的具体设计，分析隔爆条件下FF现场总线的H1网段负载能力的设计，以供大家探讨。     

"通信原理"课程教学改革探索

针对我院省重点专业“电子信息工程”的必修主干专业基础课程。“通信原理”教学中存在的不利于培养和提高学生分析问题、解决问题的能力的因素，从课程的教学内容、教学手段等方面论述了课程改革的基本构想，并对课程的实践环节——设计性实验的改革进行了探讨。     

基于主体外部轮廓的照片分割算法

在实际应用中常常需要将人像从照片的背景中有效地分割出来，通常的做法是通过提取照片中人像各部分特征来实现分割，其缺陷是计算复杂度较大，分割效果受各种干扰因素影响很大。现提出了一种基于主体外部轮廓信息的照片分割算法，通过梯度锐化、边缘保护、临近像素点相似度比较来确定图像的边界，该算法对于具有相对均匀背景的照片具有较高的计算效率。     

红外热图技术在气功研究中的应用

本文用红外技术研究发功时上肢体表温度变化的特点和它的规律。     

银狐皮毛被及皮板组织构造的研究

用光学显微镜和扫描电镜观察了国产人工饲养银狐的毛被和皮板组织构造 ,测定了毛的长度、细度、密度、毛的鳞片高度和皮板厚度。提供了毛和皮板组织学图片 15幅。