| 盐酸氟哌噻吨合成工艺研究 |
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| 引用本文： | 张立颖,刘旭亮. 盐酸氟哌噻吨合成工艺研究[J]. 广州化工, 2013, 0(24): 64-65 |
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| 作者姓名： | 张立颖 刘旭亮 |
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| 作者单位： | [1]山东理工大学,山东淄博255049 [2]山东新华制药股份有限公司,山东淄博255086 |
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| 摘 要： | 对盐酸氟哌噻吨合成工艺进行了优化研究。以2-三氟甲基-9-噻吨酮为起始原料，与1-（2-苄氧乙基）-4-（3-氯丙基）哌嗪进行格式反应，经脱水生成10-[3-[4-（2-苄氧乙基）-1-哌嗪基]丙基-9-羟基-2-三氟甲基噻吨，然后脱保护反应得氟哌噻吨游离碱，成盐而得盐酸氟哌噻吨成品，容量分析法检测纯度高于99．4％，收率大于59．0％。
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| 关 键 词： | 盐酸氟哌噻吨 2-三氟甲基-9-噻吨酮 合成 抗精神病药 |
Research on the Synthesis Process of Flupenthixol Dihydrochloride |
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| Affiliation: | ZHANG Li - ying1, LIU Xu - liang2 ( 1 Shandong University of Technology, Shandong Zibo 255049 ; 2 Shandong Xinhua Pharmaceutical Co. , Ltd. , Shandong Zibo 255086, China) |
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| Abstract: | The synthetic process of flupenthixol dihydrochloride was studied. With 2 - trifluoromethylthioxanthen - 9 - one as starting material through Grignard reaction, dehydrationg was prepared, which was subject to salt formation. The average yield of flupenthixol dihydrochloride was more than 59.0% with a purity of 99. 4%. |
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| Keywords: | flupenthixol dihydrochloride 2 - trifluoromethylthioxanthen - 9 - one synthesis antipsychotic drug |
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