| 二氟乙酰乙酸乙酯的合成 |
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| 引用本文： | 程经顺,田笑朋.二氟乙酰乙酸乙酯的合成[J].安徽化工,2012,38(1):45-46. |
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| 作者姓名： | 程经顺 田笑朋 |
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| 作者单位： | 张家港市三联化工科技有限公司,江苏张家港,225619;张家港市三联化工科技有限公司,江苏张家港,225619 |
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| 摘 要： | 二氟乙酸乙酯和乙酸乙酯(摩尔比为1∶3)在乙醇钠催化下进行克莱森酯缩合反应,得到二氟乙酰乙酸乙酯。反应在50℃下进行4h,以过量的乙酸乙酯和反应生成的乙醇共沸除掉乙醇,使反应进行完全。除掉溶剂后减压蒸馏得纯度大于99%的产品,产品收率68.14%。
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| 关 键 词： | 二氟乙酰乙酸乙酯 乙酸乙酯 克莱森缩合 |
Synthesis of Ethyl 4,4-Difluoroacetoacetate |
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| CHENG Jing-shun,TIAN Xiao-peng.Synthesis of Ethyl 4,4-Difluoroacetoacetate[J].Anhui Chemical Industry,2012,38(1):45-46. |
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| Authors: | CHENG Jing-shun TIAN Xiao-peng |
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| Affiliation: | CHENG Jing-shun,TIAN Xiao-peng |
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| Abstract: | Ethyl 4,4-difluoroacetoacetate was synthesized from ethyl acetate and 4,4-difluoroacetoacetate（mole ratio 3∶1） with sodium ethylate.The reaction was carried at 50℃ for 4 hours.Ethanol from the reaction was removed by distilling the azeotropic of ethyl acetate and ethanol to complete the reaction.The yield was 68.14% with purity no less than 99%. |
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| Keywords: | ethyl 4 4-difluoroacetoacetate ethyl acetate Clasien-Schmidt |
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