Towards Understanding the Genetic Nature of Vasovagal Syncope |
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Authors: | Natalia Matveeva Boris Titov Elizabeth Bazyleva Alexander Pevzner Olga Favorova |
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Affiliation: | 1.National Medical Research Center for Cardiology, 121552 Moscow, Russia; (N.M.); (B.T.); (E.B.); (A.P.);2.Department of Molecular Biology and Medical Biotechnology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia |
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Abstract: | Syncope, defined as a transient loss of consciousness caused by transient global cerebral hypoperfusion, affects 30–40% of humans during their lifetime. Vasovagal syncope (VVS) is the most common cause of syncope, the etiology of which is still unclear. This review summarizes data on the genetics of VVS, describing the inheritance pattern of the disorder, candidate gene association studies and genome-wide studies. According to this evidence, VVS is a complex disorder, which can be caused by the interplay between genetic factors, whose contribution varies from monogenic Mendelian inheritance to polygenic inherited predisposition, and external factors affecting the monogenic (resulting in incomplete penetrance) and polygenic syncope types. |
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Keywords: | syncope vasovagal syncope genetics complex disorders susceptibility twin studies family studies candidate gene association studies genome-wide studies |
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