Exploring Aβ Proteotoxicity and Therapeutic Candidates Using Drosophila melanogaster |
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Authors: | Greta Elovsson Liza Bergkvist Ann-Christin Brorsson |
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Affiliation: | 1.Division of Molecular Biotechnology, Department of Physics, Chemistry and Biology, Linköping University, 58183 Linköping, Sweden;2.Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 17164 Solna, Sweden; |
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Abstract: | Alzheimer’s disease is a widespread and devastating neurological disorder associated with proteotoxic events caused by the misfolding and aggregation of the amyloid-β peptide. To find therapeutic strategies to combat this disease, Drosophila melanogaster has proved to be an excellent model organism that is able to uncover anti-proteotoxic candidates due to its outstanding genetic toolbox and resemblance to human disease genes. In this review, we highlight the use of Drosophila melanogaster to both study the proteotoxicity of the amyloid-β peptide and to screen for drug candidates. Expanding the knowledge of how the etiology of Alzheimer’s disease is related to proteotoxicity and how drugs can be used to block disease progression will hopefully shed further light on the field in the search for disease-modifying treatments. |
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Keywords: | Alzheimer’ s disease amyloid-β peptide proteotoxicity drug candidates Drosophila melanogaster |
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