The paired-pulse index: a measure of hippocampal dentate granule cell modulation |
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Authors: | JD Bronzino JH Blaise PJ Morgane |
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Affiliation: | Biomedical Engineering Program, Trinity College/The University of Connecticut, Hartford, USA. |
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Abstract: | This study was undertaken to assess whether the paired-pulse index (PPI) is an effective measure of the modulation of dentate granule cell excitability during normal development. Paired-pulse stimulations of the perforant path were, therefore, used to construct a PPI for 15-, 30-, and 90-day old, freely moving male rats. Significant age-dependent differences in the PPI were obtained. Fifteen-day old rats showed significantly less inhibition at short interpulse intervals interpulse interval (IPI): 20 to 30 msec), a lack of facilitation at intermediate IPIs (50 to 150 msec), and significantly less inhibition at longer IPIs (300 to 1,000 msec) than adults. |
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