Arg-Gly-Asp (RGD) Modified Biomimetic Polymeric Materials |
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Authors: | Xufeng NIU Yuanliang WANG Yanfeng LUO Juan XIN Yonggang LI |
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Affiliation: | Key Lab of Biomechanics & Tissue Engineering, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China |
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Abstract: | The new generation of biomaterials focuses on the design of biomimetic polymeric materials that are capable of eliciting specific cellular responses and directing new tissue formation. Since Arg-Gly-Asp (RGD) sequences have been found to promote cell adhesion in 1984, numerous polymers have been functionalized with RGD peptides for tissue engineering applications. This review gave the advance in RGD modified biomimetic polymeric materials, focusing on the mechanism of RGD, the surface and bulk modification of polymer with RGD peptides and the evaluation in vitro and in vivo of the modified biomimetic materials. |
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Keywords: | Arg-Gly-Asp (RGD) Biomimetic materials Polymer |
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