| (E)-3-烷烯羧酸的合成 |
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| 引用本文： | 张适适,田红玉,孙宝国,彭娟,杨涵.(E)-3-烷烯羧酸的合成[J].精细化工,2006,23(11):1125-1127. |
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| 作者姓名： | 张适适 田红玉 孙宝国 彭娟 杨涵 |
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| 作者单位： | 北京工商大学,化学与环境工程学院,北京,100037 |
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| 基金项目： | 北京市教委科技发展计划项目 |
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| 摘 要： | 以脂肪醛与丙二酸为原料,通过Knoevenagel反应制备了(E)-3-烷烯羧酸,反应以二甲苯为溶剂,在回流条件下进行。考察了哌啶、吡啶及4-二甲氨基吡啶(DMAP)对反应产物的影响。结果表明,采用哌啶催化时,反应产率最高,可达70%左右,(E)-3-烷烯羧酸与副产物α,β-不饱和羧酸的摩尔比可达12/1以上;DMAP作催化剂,产率较低,在60%左右,反应选择性略高于哌啶;吡啶作催化剂时产率最低,反应选择性也最差,(E)-3-烷烯羧酸与副产物α,β-不饱和羧酸的摩尔比只有3/1。
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| 关 键 词： | (E)-3-烷烯羧酸 Knoevenagel反应 脂肪醛 丙二酸 |
| 文章编号： | 1003-5214（2006）11-1125-03 |
| 收稿时间： | 2006-05-09 |
| 修稿时间： | 2006-05-092006-07-04 |
Synthesis of (E)-3-Alkenoic Acids |
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| ZHANG Shi-shi,TIAN Hong-yu,SUN Bao-guo,PENG Juan,YAN Han.Synthesis of (E)-3-Alkenoic Acids[J].Fine Chemicals,2006,23(11):1125-1127. |
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| Authors: | ZHANG Shi-shi TIAN Hong-yu SUN Bao-guo PENG Juan YAN Han |
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| Affiliation: | School of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, China |
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| Abstract: | (E)-3-Alkenoic acids(Ⅰ) were synthesized by Knoevenagel reactions of aliphatic aldehydes with malonic acid in xylene under reflux.The effect of piperidine,pyridine and 4-dimethylaminopyridine(DMAP) as catalyst on the reaction was investigated.With piperidine as catalyst,yield of the product Ⅰ was the highest,around 70%,and the molar ratio of Ⅰ to the by product,α,β-unsaturated carboxylic acids(Ⅱ),was up to 12∶1.DMAP gave lower yield(about 60%) and slightly higher selectivity.Pyridine gave the poorest yield and selectivity that the molar ratio of Ⅰto Ⅱwas only 3∶1. |
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| Keywords: | (E)-3-alkenoic acids Knoevenagel reaction aliphatic aldehyde malonic acid |
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