| 芦丁明胶微球的制备工艺研究及性能表征 |
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| 引用本文： | 苏秀霞,赵艳,李仲谨,陈红海.芦丁明胶微球的制备工艺研究及性能表征[J].食品科技,2011(1):219-223. |
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| 作者姓名： | 苏秀霞 赵艳 李仲谨 陈红海 |
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| 作者单位： | 陕西科技大学教育部轻化工助剂化学与技术重点实验室; |
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| 基金项目： | 国家自然科学基金资助项目(50573046); 陕西省教育厅产业化培育项目(02JC05); 陕西省星火计划(2004kx3-10) |
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| 摘 要： | 以明胶为载体,液体石蜡为油相,Span80为乳化剂,戊二醛为交联剂,采用乳化交联法制备芦丁明胶微球,通过单因素实验和正交设计实验筛选出最佳工艺条件,并对工艺重现性进行了考察。利用扫描电镜、红外光谱、X衍射图谱等手段对产物进行了表征,计算出明胶微球的载药量和包封率。结果表明:芦丁用量及交联剂用量是影响微球性能的主要因素;微球形态圆整、表面光滑、大小均匀,其粒径为5～20μm,载药量为3.55%,包封率为94.5%。
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| 关 键 词： | 芦丁 微球 正交设计 乳化交联 |
Preparing rutin gelatin microspheres and characterization |
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| SU Xiu-xia,ZHAO Yan,? LI Zhong-jin,CHEN Hong-hai.Preparing rutin gelatin microspheres and characterization[J].Food Science and Technology,2011(1):219-223. |
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| Authors: | SU Xiu-xia ZHAO Yan ? LI Zhong-jin CHEN Hong-hai |
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| Affiliation: | (Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Institute of Chemistry and Chemical Engineering,Shaanxi University of Science & Technology,XI’an 710021) |
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| Abstract: | In this study the single factor experiment and orthogonal experimental were designed to optimize the best techniques of preparing rutin gelatin microspheres.Rutin gelatin microspheres were prepared by emulsion chemical-cross linking method with degradable gelatin as carrier,liquid paraffin as oil phase,Span80 as emulsifier,and the technique reproducibility of microspheres was studied.The surface morphology of the microspheres was observed by SEM,the formation of the drug microspheres was confirmed by FT-IR ... |
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| Keywords: | rutin microsphere orthogonal experimental design emulsion chemical-cross linking |
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