| 白首乌多糖抗CCl4小鼠肝损伤作用研究 |
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| 引用本文： | 张为,董兆稀,赵冰清,曾智.白首乌多糖抗CCl4小鼠肝损伤作用研究[J].食品科技,2011(8):57-59,63. |
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| 作者姓名： | 张为 董兆稀 赵冰清 曾智 |
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| 作者单位： | 湖南师范大学医学院;中国人民大学外国语学院;湖南省南县十八湾食品制造有限公司; |
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| 基金项目： | 湖南省科技厅研究课题(070234); 湖南省中医药管理局科研基金项目(2008082); 湖南省教育厅大学生创新性课题(09-043-0094) |
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| 摘 要： | 目的:研究耳叶牛皮消多糖对四氯化碳诱导的小鼠急性肝损伤的保护作用。方法:80只雄性昆明小鼠随机分为正常对照组,模型对照组,阳性对照组,大、中、小剂量给药组。大、中、小剂量给药组分别按500、250、100mg/kg灌胃耳叶牛皮消多糖,阳性对照组80mg/kg灌胃护肝片溶液,正常对照组和模型对照组以等体积生理盐水灌胃,共7d。第7天,模型对照组、阳性对照组和给药组按10mL/kg腹腔注射1%CCl4豆油溶液,正常对照组腹腔注射等体积生理盐水。24h后比较各组丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)的含量。结果:耳叶牛皮消多糖能显著降低各组ALT和AST含量的升高(P<0.05)。结论:耳叶牛皮消多糖对四氯化碳所致小鼠急性肝损伤具有一定的保护作用。
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| 关 键 词： | 耳叶牛皮消 多糖 四氯化碳 肝损伤 |
Effect of polysaccharide from Cynanchum auriculatum Royle ex Wight against CCl_4-induced liver injury in mice |
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| ZHANG Wei,DONG Zhao-xi,ZHAO Bing-qing,ZENG Zhi.Effect of polysaccharide from Cynanchum auriculatum Royle ex Wight against CCl_4-induced liver injury in mice[J].Food Science and Technology,2011(8):57-59,63. |
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| Authors: | ZHANG Wei DONG Zhao-xi ZHAO Bing-qing ZENG Zhi |
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| Affiliation: | ZHANG Wei1,DONG Zhao-xi2,ZHAO Bing-qing1*,ZENG Zhi3(1.Medical College of Hunan Normal University,Changsha 410013,2.School of Foreign Language,Renmin University of China,Beijing 100872,3.18 Bay Food Manufacturing Co.Ltd.,South County,Hunan,South County 413211) |
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| Abstract: | Objective:To study the protective effect of polysaccharide from Cynanchum auriculatum Royle ex Wight against CCl4-induced liver injury in mice.Methods:Eighty male mice from Kunming were rando mly divided into normal control group,model control group,positive control group,high-dosage group,middle-dosage group and low-dosage group.The mice divided into the above 6 groups were fed for 7 days.The drug groups were by gavage with 500,250,100mg/kg polysaccharide from Cynanchum auriculatum Royle ex Wight,positive ... |
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| Keywords: | Cynanchum auriculatum Royle ex Wight polysaccharide CCl4 hepatic injury |
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