| 混旋扁桃酸衍生物的高效液相色谱法拆分 |
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| 引用本文： | 薛洪宝,刘庆彬,张福军,张占辉. 混旋扁桃酸衍生物的高效液相色谱法拆分[J]. 河北化工, 2007, 30(1): 43-45,64 |
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| 作者姓名： | 薛洪宝 刘庆彬 张福军 张占辉 |
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| 作者单位： | 1. 蚌埠医学院,安徽,蚌埠,233000;河北师范大学化学化工研究所,河北,石家庄,050091
2. 河北师范大学化学化工研究所,河北,石家庄,050091 |
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| 摘 要： | 采用天然手性中心多糖类手性反相色谱固定相填料,高氯酸钠水溶液和乙腈为流动相,在不同的流动相比例下拆分多种扁桃酸衍生物,从而得出拆分手性化合物的规律性,与手性碳相连的基团越大,越容易被拆分.
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| 关 键 词： | 液相色谱 手型固定相 对映体混合物 手性分离 扁桃酸 |
| 文章编号： | 1003-5095（2007）01-0043-04 |
| 修稿时间： | 2006-11-08 |
Chiral Stationary Phase for Separation of Enantiomorph Derivatives of Mandelic acid in High Performance Liquid Chromatography |
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| XUE Hong-bao,LIU Qing-bin,ZHANG Fu-jun,ZHANG Zhan-hui. Chiral Stationary Phase for Separation of Enantiomorph Derivatives of Mandelic acid in High Performance Liquid Chromatography[J]. Hebei Chemical Engineering and Industry, 2007, 30(1): 43-45,64 |
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| Authors: | XUE Hong-bao LIU Qing-bin ZHANG Fu-jun ZHANG Zhan-hui |
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| Affiliation: | 1. Bengbu Medical College, Bengbu 233000,China; 2. Insitute of Chemistry and Chemical Engineering, Hebei Normal University, Shijiazhuang 050091 ,China |
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| Abstract: | Using reversed-phase on chiral-cel OD-R, a polysaccharide-derived loading material chiral stationary phase, sodium perchlorate monohydrate solution and acetonitrile--mobile phase of high performance liquid chromatography separate enantiomorph derivatives of mandelic acid by adjusting different proportion of mobile phase. In this process, the regularity of chiral compounds that chiral center connect with long carbon chains directly can be more easy separated than that of chiral center connect with short carbon chains. |
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| Keywords: | liquid chromatography ohiral stationary phase enantiomorph chiral separation mandelic acid |
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