|
|||||
|
|
Synthesis of Various Water-Soluble G60 Derivatives and Their Superoxide-Quenching Activity |
|
| Authors: | Kensuke Okuda Takashi Hirota Masaaki Hirobe Tetsuo Nagano Masataka Mochizuki Tadahiko Mashino |
| Affiliation: | 1. Faculty of Pharmaceutical Sciences , Okayama University , Tsushimanaka 1-1-1, Okayama, 700-8530, Japan;2. Faculty of Pharmaceutical Sciences , University of Tokyo , Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan;3. Kyoritsu College of Pharmacy , Shibakoen 1-5-30, Minato-ku, Tokyo, 105-8512, Japan |
| Abstract: | Abstract In order to examine the utility of fullerene as a medicinal application, we evaluated the reaction between fullerene derivatives and active oxygen species in vitro. This paper describes the synthesis of various water-soluble C60 derivatives (cationic and anionic) and evaluation of their superoxide (O2 ?) quenching activity. Cationic C60 derivatives showed fairly high efficiency. |
| Keywords: | |