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Photo-Induced Cytotoxicity of Water-Soluble Fullerene |
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| Authors: | N Nakajima C Nishi F M Li Y Ikada |
| Affiliation: | 1. Research Center for Biomedical Engineering , Kyoto University , 53 Kawahara-cho, Shyogoin, Sakyo-ku, Kyoto, 606, Japan;2. Department of Chemistry, Polymer Division , Peking University , 53 Kawahara-cho, Shyogoin, Sakyo-ku, Kyoto, 606, Japan |
| Abstract: | Abstract The reaction of C60 with poly(ethylene glycol) having a terminal primary amino group or a mixture of ethylene diamine and poly(ethylene glycol) having terminal carboxyl groups resulted in formation of water-soluble C60 conjugates. These conjugates showed strong cytotoxicity to L929 cells upon visible light irradiation as a result of superoxide production. |
| Keywords: | Fullerene Cytotoxicity Superoxide Superoxide dismutase |