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Remote‐Controlled Hydrogel Depots for Time‐Scheduled Vaccination |
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| Authors: | Raphael J. Gübeli Désirée Hövermann Hanna Seitz Balder Rebmann Ronald G. Schoenmakers Martin Ehrbar Ghislaine Charpin‐El Hamri Marie Daoud‐El Baba Martin Werner Martin Müller Wilfried Weber |
| Affiliation: | 1. Faculty of Biology, SGBM Spemann Graduate School of Biology and Medicine, University of Freiburg, Albertstrasse 19A, 79104 Freiburg, Germany;2. Faculty of Biology, BIOSS Centre for Biological Signalling Studies, University of Freiburg, Sch?nzlestrasse 18, 79104 Freiburg, Germany;3. German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany;4. Department of Obstetrics, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland;5. Université de Lyon, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France;6. University Medical Center, Institute of Pathology, University of Freiburg, Breisacherstrasse 115A, 79106 Freiburg, Germany |
| Abstract: | Remote‐controlled drug depots represent a highly valuable tool for the timely controlled administration of pharmaceuticals in a patient compliant manner. Here, the first pharmacologically controlled material that allows for the scheduled induction of a medical response in mice is described. To this aim, a novel, humanized biohybrid material that releases its cargo in response to a small‐molecule stimulus licensed for human use is developed. The functionality of the material in mice is demonstrated by the remote‐controlled delivery of a vaccine against the oncogenic human papillomavirus type 16. It is shown that the biohybrid depot‐mediated immunoprotection is equivalent to the classical multi‐injection‐based vaccination. These results indicate that this material can be used as a universal remote‐controlled vehicle for the patient‐compliant delivery of vaccines and pharmaceuticals. |
| Keywords: | biohybrid materials stimulus‐responsive vaccines hydrogels |