| 9-芴甲氧羰基-对甲磺酰氨-(L)-苯丙氨酸的全合成 |
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| 引用本文： | 马燕,王朝阳.9-芴甲氧羰基-对甲磺酰氨-(L)-苯丙氨酸的全合成[J].精细化工原料及中间体,2010(1). |
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| 作者姓名： | 马燕 王朝阳 |
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| 作者单位： | 西南科技大学生命科学与工程学院;四川成都爱斯特医药技术有限公司; |
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| 摘 要： | (L)-苯丙氨酸经硝化、酯化、叔丁氧羰基(Boc)保护α-氨基、Pd/C还原对位硝基、对甲磺酰氯(MSCl)保护对位氨基、经水解反应后,在酸性条件下脱去叔丁氧羰基(Boc)基团,碱性条件下引入9-芴甲氧羰基琥珀酰亚胺(Fmoc-osu),最终生成标题化合物,并且对所合成标题化合物进行了HNMR结构确证。
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| 关 键 词： | （L）-苯丙氨酸 芴甲氧羰酰琥珀酰亚胺（Fmoc-osu） 对甲磺酰氯（MSCl） 合成 保护 |
Total Synthesis and Characterization of 9-Fmoc- Sulfonylurea Acyl Ammonia-L-Phenylalanine |
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| Abstract: | The title compound was synthesized from L-phenylalamine via nitration, esterification, the amino of L-phenylalamine was protected using base-liable Boc group,the reduction of para-nitryl was completed by Pd/C,the para-amino group was protected using methylsufonyl chloride,after via saponification, Boc was removed in acid condition , and Fmoc-osu could introduce Fmoc group in basic condition, finally the target compound was obtained,the structure was confirmed by 1HNMR spectra. |
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| Keywords: | L-Phenylalamine Fmoc-osu MSCl synthesis protection |
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