| 含中草药成分的纤维制备、结构与性能研究 Ⅲ.纤维素/聚乙二醇/生姜共混纤维的药物缓释动力学模型 |
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| 引用本文： | 丁宏贵,王志鑫,刘佃森,顾庆锋,沈青. 含中草药成分的纤维制备、结构与性能研究 Ⅲ.纤维素/聚乙二醇/生姜共混纤维的药物缓释动力学模型[J]. 纤维素科学与技术, 2005, 13(3): 25-28 |
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| 作者姓名： | 丁宏贵 王志鑫 刘佃森 顾庆锋 沈青 |
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| 作者单位： | 1. 东华大学,材料科学与工程学院
2. 东华大学,纤维材料改性国家重点实验室;东华大学,材料科学与工程学院,中心实验室,上海,200051 |
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| 基金项目： | 教育部留学人员启动基金资助项目(2B10601) |
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| 摘 要： | 应用电导方法研究了生姜成分从纤维素/聚乙二醇/生姜共混纤维中的缓释。研究结果表明:随着释放环境温度的升高,药物的释放愈加明显;但是当环境温度接近纤维本体玻璃化转变温度时,药物释放会受到抑制。生姜成分从药物纤维中的释放遵循零级、一级和二级并存的较复杂的动力学模型,但其中起主导作用的是零级释放速率常数。
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| 关 键 词： | 生姜 共混纤维 缓释 电导 动力学模型 |
| 文章编号： | 1004-8405(2005)03-0025-04 |
| 修稿时间： | 2004-11-17 |
Studies of Preparation, Structure and Properties of Fibers Containing Chinese Herbs Ⅲ. Dynamical Model for Drug Release of Cellulose/Poly(ethylene glycol)/Ginger Blend Fiber |
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| DING Hong-gui,WANG Zhi-xin,LIU Dian-sen,GU Qing-feng,SHEN Qing. Studies of Preparation, Structure and Properties of Fibers Containing Chinese Herbs Ⅲ. Dynamical Model for Drug Release of Cellulose/Poly(ethylene glycol)/Ginger Blend Fiber[J]. Journal of Cellulose Science and Technology, 2005, 13(3): 25-28 |
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| Authors: | DING Hong-gui WANG Zhi-xin LIU Dian-sen GU Qing-feng SHEN Qing |
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| Affiliation: | DING Hong-gui1,WANG Zhi-xin1,LIU Dian-sen1,GU Qing-feng1,SHEN Qing2,3* |
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| Abstract: | Taking conductivity as a tool to study the ginger components released from a cellulose/ poly(ethylene glycol)/ginger blend fiber, results showed that this process was controlled by the temperature and in general the higher the temperature the faster is the release, except the temperature approaches to a phase change temperature for bulk fiber. A model deduced based on recorded conductivity curves indicated that the drug release was following a complex model because the rate constants determined to have note only in zero and first, but also in second. However, the truth is of them the zero rate constant to be a dominator due to it higher than others. |
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| Keywords: | ginger blend fiber drug release conductance dynamical model |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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