| 2-巯基-3-苄氧基吡啶的合成 |
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| 引用本文： | 皮红军,廖道华,董捷,王宏健,楼江松. 2-巯基-3-苄氧基吡啶的合成[J]. 精细化工中间体, 2006, 36(5): 47-49 |
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| 作者姓名： | 皮红军 廖道华 董捷 王宏健 楼江松 |
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| 作者单位： | 华东理工大学,制药工程系,上海,200237 |
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| 摘 要： | 报道了超高效除草剂三氟啶磺隆的中间体2-巯基-3-苄氧基吡啶的合成方法。首先以2-氯-3-羟基吡啶(2)为原料,与溴化苄(3)在丙酮中反应制备2-氯-3-苄氧基吡啶(4);化合物4再与硫脲在无水乙醇反应得到2-巯基-3-苄氧基吡啶。总收率75.61%。
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| 关 键 词： | 除草剂 三氟啶磺隆 2-巯基-3-苄氧基吡啶 2-氯-3-羟基吡啶 |
| 文章编号： | 1009-9212(2006)05-0047-03 |
| 收稿时间： | 2006-06-28 |
| 修稿时间： | 2006-06-28 |
Synthesis of 2-Mercapto-3-benzyloxypyridine |
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| PI Hong-jun,LIAO Dao-hua,DONG Jie,WANG Hong-jian,LOU Jiang-song. Synthesis of 2-Mercapto-3-benzyloxypyridine[J]. Fine Chemical Intermediates, 2006, 36(5): 47-49 |
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| Authors: | PI Hong-jun LIAO Dao-hua DONG Jie WANG Hong-jian LOU Jiang-song |
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| Affiliation: | College of Chemistry and Pharmaceutical Engineering, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | 2-Mercapto-3-benzyloxypyridine(1)was an important intermediate of herbicide trifloxysulfuron.A new practical synthesis method of 2-mercapto-3-benzyloxypyridine(1)was described in the paper.2-Chloro-3-hydroxylpyridine was treated with 1.0 equiv.of benzyl bromide in acetone to form 2-chloro-3-benzyloxypyridine(4)in 97% yield.The compound 4 then reacted with 1.2 equiv.of thiourea in anhydrous ethanol to produce 2-mercapto-3-benzyloxypyridine(1)in 77.95% yield.The total yield of the product was 75.61%. |
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| Keywords: | herbicide trifloxysulfuron 2-mercapto-3-benzyloxypyridine 2-chloro-3-hydroxylpyridine synthesis |
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