| 15Nb─色胺和[2─15N]川芎哚的合成 |
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| 引用本文： | 唐刚华,王世真,姜国辉. 15Nb─色胺和[2─15N]川芎哚的合成[J]. 核技术, 1999, 22(8): 504-507 |
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| 作者姓名： | 唐刚华 王世真 姜国辉 |
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| 作者单位： | 中国医学科学院-中国协和医科大学北京协和医院,北京,100730 |
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| 基金项目： | 中国科学院资助项目，广东省博士启动基金，，，， |
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| 摘 要： | 以（α－＾１５Ｎ）甘氨酸起始原料经７步反应合成＾１５Ｎｂ－色胺，产率为４５％，以制备的＾１５Ｎｂ－色胺为原料经３步反应合成（２－＾１５Ｎ）川芎哚，产率为２２．２％，标记川芎哚经衍生化后用ＧＣ－ＭＳ测得＾１５Ｎ丰度大于９０％，结果表明，合成的标记物满足的代谢研究的需要。
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| 关 键 词： | 15Nb-色胺 [2-15N]川芎哚 合成 |
Syntheses of [2-15N] tryptamine and [2-15N] perlolyrine |
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| TANG Ganghua,WANG Shihchen,JIANG Guohui. Syntheses of [2-15N] tryptamine and [2-15N] perlolyrine[J]. Nuclear Techniques, 1999, 22(8): 504-507 |
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| Authors: | TANG Ganghua WANG Shihchen JIANG Guohui |
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| Abstract: | 15Nb-tryptamine was synthesized starting from [a -15N] glycine via 7 steps. Theyield of 15Nb-tryptamine from [a -15N] glycine was 45%. [2-15N] perlolyrine wassynthesized from 15Nb-tryptamine via 3 steps, the yield of [2-15N] perlolyrine from15Nb-tryptamine was 22.2%. The 15N abundance of [2-15N] perlolyrine was morethan 90%. The synthetic showed that the synthetic compounds were suitable for thestuding of drug metabolism. |
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| Keywords: | ~(15)N_b-tryptamine [2-~(15)N]perlolyrine Synthesis |
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