Efflux pump-mediated quinolone resistance in Staphylococcus aureus strains wild type for gyrA, gyrB, grlA, and norA |
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Authors: | JL Mu?oz-Bellido M Alonzo Manzanares JA Martínez Andrés MN Guttiérrez Zufiaurre G Ortiz M Segovia Hernández JA García-Rodríguez |
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Affiliation: | Departamento de Microbiologia, Hospital Universitario de Salamanca, Spain. |
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Abstract: | Fluoroquinolone efflux was studied in 47 Staphylococcus aureus clinical strains with MICs of ciprofloxacin (CFX) of < or = 2 micrograms/ml. Forty-three strains were wild type for gyrA, gyrB, and grlA quinolone resistance-determining regions and for norA and its promoter region. Forty of these strains (MICs of CFX, 0.1 to 0.2 microgram/ml) did not show efflux of fluoroquinolones. Three strains (MICs of CFX, 1 to 2 micrograms/ml) showed efflux. These results suggest that efflux can appear in S. aureus clinical strains in the absence of mutations in norA and its promoter. |
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